Topic
Dysarthria
About: Dysarthria is a research topic. Over the lifetime, 2402 publications have been published within this topic receiving 56554 citations.
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TL;DR: It is demonstrated that SID in essential tremor patients is associated with both, motor cortex and cerebellar connectivity and the identified fiber-based atlas structure might contribute to future postoperative programming strategies to achieve optimal tremor control without speech impairment in ET patients with thalamic DBS.
Abstract: Objective To gain insights into structural networks associated with stimulation-induced dysarthria (SID) and to predict stimulation-induced worsening of intelligibility in essential tremor patients with bilateral thalamic deep brain stimulation (DBS). Methods Monopolar reviews were conducted in 14 essential tremor patients. Testing included determination of SID thresholds, intelligibility ratings and a fast syllable repetition task. Volumes of tissue activated (VTAs) were calculated to identify discriminative fibers for stimulation-induced worsening of intelligibility in a structural connectome. The resulting fiber-based atlas structure was than validated in a leave-one-out design. Results Fibers determined as discriminative for stimulation-induced worsening of intelligibility were mainly connected to the ipsilateral precentral gyrus as well as to both cerebellar hemispheres and the ipsilateral brainstem. In the thalamic area, they ran laterally to the thalamus and postero-medially to the subthalamic nucleus, in close proximity, mainly antero-laterally, to fibers beneficial for tremor control as published by Al-Fatly et al. (2019). The overlap of the respective clinical stimulation setting’s VTAs with these fibers explained 62.4% (p Interpretation This study demonstrates that SID in essential tremor patients is associated with both, motor cortex and cerebellar connectivity. Furthermore, the identified fiber-based atlas structure might contribute to future postoperative programming strategies to achieve optimal tremor control without speech impairment in ET patients with thalamic DBS.
2 citations
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2 citations
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TL;DR: In this article , a deep learning-based voice conversion system with phonetic posteriorgram (PPG) features, called the DVC-PPG system, was proposed for dysarthric patients and investigated the benefits under challenging application conditions.
2 citations
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TL;DR: In this article , the effect of transcranial direct current stimulation combined with integrative speech therapy in a child with cerebral palsy was investigated using a parameterized test for the Brazilian Portuguese speech - ABFW.
2 citations
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01 Jan 2018
TL;DR: The protocol showed to have potential clinical utility to assess dysarthria in neurological patients, due to its completeness and ease of training and administration and Lin’s Concordance Correlation Coefficient determined the consistency of measurements between the same rater and among different raters with different levels of expertise.
Abstract: Dysarthria is a motor speech disorder that results from an impairment of the muscles devoted to speech production, thus affecting the movements of the orofacial district. The type and severity of dysarthria depend on which structures of the central or peripheral nervous system are affected. Due to the vast range of acute and progressive neurological disorders that may cause dysarthria, its prevalence may be not negligible. In Italian clinical practice dysarthria is assessed using a standardized protocol, which has never been validated. The aim of the study is to explore the intraand inter- reliability of a short-form of a protocol to assess dysarthria and compare scoring of the test face-to-face versus via video of patient assessment, which is broadly used in the Italian clinical practice. 50 dysarthric patients were enrolled for this pilot study and assessed by “Protocollo di Valutazione della Disartria”. Lin’s Concordance Correlation Coefficient (CCC) determined the consistency of measurements between the same rater and among different raters with different levels of expertise. Scoring was done both during face-to-face assessments and while watching video recordings of patients’ evaluations. Results indicated a good consistency of ratings in repeated measures over time (video-assessment intra-rater CCC>0.8). Nevertheless, inter-rater reliability was less satisfactory (video-assessment scoring inter-rater CCC<0.8), especially in the face-to-face administration of the protocol (face-to-face/video inter-rater CCC<0.8). In conclusion, the protocol showed to have potential clinical utility to assess dysarthria in neurological patients, due to its completeness and ease of training and administration. However generalizations of the findings are limited, due to the characteristics of the study. Indeed, further research is required for a better validation of the instrument.
2 citations