Topic
Dysarthria
About: Dysarthria is a research topic. Over the lifetime, 2402 publications have been published within this topic receiving 56554 citations.
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TL;DR: This paper studies the application of ANNs as a fixed-length isolated-word SI ASR for individuals who suffer from dysarthria and identifies the best-performing set of MFCC parameters, which can represent dysarthric acoustic features to be used in Artificial Neural Network (ANN)-based ASR.
63 citations
TL;DR: Distinctive features of dysarthria and dyspraxia are found in individuals with GRIN2A mutations, often in the setting of epilepsy-aphasia syndromes; Dysarthria has not been previously recognized in these disorders.
Abstract: Objective: To delineate the specific speech deficits in individuals with epilepsy-aphasia syndromes associated with mutations in the glutamate receptor subunit gene GRIN2A . Methods: We analyzed the speech phenotype associated with GRIN2A mutations in 11 individuals, aged 16 to 64 years, from 3 families. Standardized clinical speech assessments and perceptual analyses of conversational samples were conducted. Results: Individuals showed a characteristic phenotype of dysarthria and dyspraxia with lifelong impact on speech intelligibility in some. Speech was typified by imprecise articulation (11/11, 100%), impaired pitch (monopitch 10/11, 91%) and prosody (stress errors 7/11, 64%), and hypernasality (7/11, 64%). Oral motor impairments and poor performance on maximum vowel duration (8/11, 73%) and repetition of monosyllables (10/11, 91%) and trisyllables (7/11, 64%) supported conversational speech findings. The speech phenotype was present in one individual who did not have seizures. Conclusions: Distinctive features of dysarthria and dyspraxia are found in individuals with GRIN2A mutations, often in the setting of epilepsy-aphasia syndromes; dysarthria has not been previously recognized in these disorders. Of note, the speech phenotype may occur in the absence of a seizure disorder, reinforcing an important role for GRIN2A in motor speech function. Our findings highlight the need for precise clinical speech assessment and intervention in this group. By understanding the mechanisms involved in GRIN2A disorders, targeted therapy may be designed to improve chronic lifelong deficits in intelligibility.
62 citations
TL;DR: Investigation of stop-gap duration, voice onset time (VOT), and vowel duration in intelligible speakers with amyotrophic lateral sclerosis indicated that the ALS speakers, as a group, exhibited a direct relationship between stop- gap and vowel durations associated with productions of /t/ and /k/.
Abstract: The purpose of this study was to investigate stop-gap duration, voice onset time (VOT), and vowel duration in intelligible speakers with amyotrophic lateral sclerosis (ALS) Broadband sound spectrograms were used to measure 8 normal and 8 ALS speakers' intelligible speech productions of monosyllabic words containing word-initial stop-plosive consonants (/p, t, k, b, d, g/) Significant differences were found between the two groups for both vowel duration and stop-gap duration; moreover, correlational analysis indicated that the ALS speakers, as a group, exhibited a direct relationship between stop-gap and vowel durations associated with productions of /t/ and /k/ No significant differences were found between the two talker groups for VOT Results will be related to the neuroanatomical and physiological mechanisms involved in dysarthric (ALS) speech
62 citations
TL;DR: The patterns and degree of consonant articulation deficits across voiced and voiceless stop plosives in 16 PD, 16 PSP, 16 MSA and 16 healthy control speakers were evaluated using acoustic and perceptual methods.
62 citations