Topic
Electroconvulsive therapy
About: Electroconvulsive therapy is a research topic. Over the lifetime, 7173 publications have been published within this topic receiving 162071 citations. The topic is also known as: ECT & electroshock therapy.
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TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
3,610 citations
TL;DR: A systematic overview and meta-analysis of randomised controlled trials and observational studies for the efficacy and safety of electroconvulsive therapy with simulated ECT, ECT versus pharmacotherapy, and different forms of ECT for patients with depressive illness found ECT is an effective short-term treatment for depression.
1,321 citations
TL;DR: increasing the electrical dosage increases the efficacy of right unilateral electroconvulsive therapy, although not to the level of bilateral therapy, and unilateral treatment is associated with less severe cognitive side effects after treatment.
Abstract: Background The efficacy of electroconvulsive therapy in major depression is established, but the importance of the electrical dosage and electrode placement in relation to efficacy and side effects is uncertain. Methods In a double-blind study, we randomly assigned 96 depressed patients to receive right unilateral or bilateral electroconvulsive therapy at either a low electrical dose (just above the seizure threshold) or a high dose (2.5 times the threshold). Symptoms of depression and cognitive functioning were assessed before, during, immediately after, and two months after therapy. Patients who responded to treatment were followed for one year to assess the rate of relapse. Results The response rate for low-dose unilateral electroconvulsive therapy was 17 percent, as compared with 43 percent for high-dose unilateral therapy (P = 0.054), 65 percent for low-dose bilateral therapy (P = 0.001), and 63 percent for high-dose bilateral therapy (P = 0.001). Regardless of electrode placement, high dosage result...
835 citations
TL;DR: It is proposed that generation of new neurons in the hippocampus may be an important neurobiologic element underlying the clinical effects of electroconvulsive seizures.
731 citations