Showing papers on "Electrode array published in 2020"

Intrinsically stretchable electrode array enabled in vivo electrophysiological mapping of atrial fibrillation at cellular resolution.

Abstract: Electrophysiological mapping of chronic atrial fibrillation (AF) at high throughput and high resolution is critical for understanding its underlying mechanism and guiding definitive treatment such as cardiac ablation, but current electrophysiological tools are limited by either low spatial resolution or electromechanical uncoupling of the beating heart. To overcome this limitation, we herein introduce a scalable method for fabricating a tissue-like, high-density, fully elastic electrode (elastrode) array capable of achieving real-time, stable, cellular level-resolution electrophysiological mapping in vivo. Testing with acute rabbit and porcine models, the device is proven to have robust and intimate tissue coupling while maintaining its chemical, mechanical, and electrical properties during the cardiac cycle. The elastrode array records epicardial atrial signals with comparable efficacy to currently available endocardial-mapping techniques but with 2 times higher atrial-to-ventricular signal ratio and >100 times higher spatial resolution and can reliably identify electrical local heterogeneity within an area of simultaneously identified rotor-like electrical patterns in a porcine model of chronic AF.

Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve.

Abstract: Retinal prostheses can restore a functional form of vision in patients affected by dystrophies of the outer retinal layer. Beyond clinical utility, prostheses for the stimulation of the optic nerve, the visual thalamus or the visual cortex could also serve as tools for studying the visual system. Optic-nerve stimulation is particularly promising because it directly activates nerve fibres, takes advantage of the high-level information processing occurring downstream in the visual pathway, does not require optical transparency and could be effective in cases of eye trauma. Here we show, in anaesthetized rabbits and with support from numerical modelling, that an intraneural electrode array with high mechanical stability placed in the intracranial segment of the optic nerve induces, on electrical stimulation, selective activation patterns in the visual cortex. These patterns are measured as electrically evoked cortical potentials via an ECoG array placed in the contralateral cortex. The intraneural electrode array should enable further investigations of the effects of electrical stimulation in the visual system and could be further developed as a visual prosthesis for blind patients.

Towards emerging EEG applications: a novel printable flexible Ag/AgCl dry electrode array for robust recording of EEG signals at forehead sites.

Abstract: Objectives. With the rapid development of EEG-based wearable healthcare devices and brain-computer interfaces (BCIs), reliable and user-friendly EEG sensors for EEG recording especially at the forehead sites are highly desirable and challenging. However, the existing EEG sensors cannot meet the requirements, since wet electrodes require tedious setup and conductive pastes or gels, and most dry electrodes show unacceptable high contact impedance. In addition, the existing electrodes cannot absorb sweat effectively, which would cause cross-interferences even short circuits between adjacent electrodes, especially in the moving scenarios, or hot and humid environment. To resolve these problems, a novel printable flexible Ag/AgCl dry electrode array was developed for EEG acquisition at forehead sites, mainly consisting of screen-printing Ag/AgCl coating, conductive sweat-absorbable sponges and flexible tines. Approach. A systematic method was also established to evaluate the flexible dry electrode array. Main results. The experimental results show the flexible dry electrode array have reproducible electrode potential, relative low electrode-skin impedance, and good stability. Moreover, the EEG signals can be effectively captured with high quality that is comparable with that of wet electrodes. Significance. All the results confirmed that the feasibility for forehead EEG recording in real-world scenarios using the proposed flexible dry electrode array, with a rapid and facile operation as well as advantages of self-application, user-friendliness and wearing comfort.

A Gel‐Free Ti3C2Tx‐Based Electrode Array for High‐Density, High‐Resolution Surface Electromyography

Abstract: Wearable sensors for surface electromyography (EMG) are composed of single- to few-channel large-area contacts, which exhibit high interfacial impedance and require conductive gels or adhesives to record high-fidelity signals These devices are also limited in their ability to record activation across large muscle groups due to poor spatial coverage To address these challenges, we have developed a novel high-density EMG array based on titanium carbide (Ti3C2Tx) MXene encapsulated in parylene-C Ti3C2Tx is a two-dimensional nanomaterial with excellent electrical, electrochemical, and mechanical properties, which forms colloidally stable aqueous dispersions, enabling safe, scalable solutions-processing Leveraging the excellent combination of metallic conductivity, high pseudocapacitance, and ease of processability of Ti3C2Tx MXene, we demonstrate the fabrication of gel-free, high-density EMG arrays which are ~8 μm thick, feature 16 recording channels, and are highly skin-conformable The impedance of Ti3C2Tx electrodes in contact with human skin is 100-1000x lower than the impedance of commercially-available electrodes which require conductive gels to be effective Furthermore, our arrays can record high-fidelity, low-noise EMG, and can resolve muscle activation with improved spatiotemporal resolution and sensitivity compared to conventional gelled electrodes Overall, our results establish Ti3C2Tx-based bioelectronic interfaces as a powerful platform technology for high-resolution, non-invasive wearable sensing technologies

Adaptive Calibration of Electrode Array Shifts Enables Robust Myoelectric Control

Abstract: Objective: The objective of this work is to develop a novel method for adaptive calibration of the electrode array shifts toward achieving robust myoelectric pattern-recognition control. Methods: This work is inspired by the idea of image object detection when high-density surface electromyogram signals recorded from a two-dimensional electrode array carry rich spatial information and can serve as a muscular activation image. A convolutional neural network involving transfer learning (from a network for image recognition) is used to learn muscular activity patterns at an original/baseline position of an electrode array. The shift of an electrode array can be estimated by identifying and matching partially overlapped regions between the training images of muscular activation and the testing images at any other position, in an unsupervised manner. Given the calibration of an electrode array shift, the identification of muscular activity patterns is implemented accordingly. The performance of the proposed method was evaluated with data recorded by a 10 × 10 electrode array placed over the forearm extensors of 10 subjects performing 6 wrist and finger extension tasks. Results: The proposed method achieved high task classification accuracies around 95% and outperformed five traditional methods under conditions with multiple designated shifts in offline experiments and a random shift in online testing. Conclusion: The proposed method is demonstrated to be a promising solution for the automatic and adaptive calibration of electrode array shifts. Significance: This work will enhance the robustness of myoelectric control systems.

Effects of Electrode Location on Estimates of Neural Health in Humans with Cochlear Implants.

Abstract: There are a number of psychophysical and electrophysiological measures that are correlated with SGN density in animal models, and these same measures can be performed in humans with cochlear implants (CIs). Thus, these measures are potentially applicable in humans for estimating the condition of the neural population (so called "neural health" or "cochlear health") at individual sites along the electrode array and possibly adjusting the stimulation strategy in the CI sound processor accordingly. Some measures used to estimate neural health in animals have included the electrically evoked compound potential (ECAP), psychophysical detection thresholds, and multipulse integration (MPI). With regard to ECAP measures, it has been shown that the change in the ECAP response as a function of increasing the stimulus interphase gap ("IPG Effect") also reflects neural density in implanted animals. These animal studies have typically been conducted using preparations in which the electrode was in a fixed position with respect to the neural population, whereas in human cochlear implant users, the position of individual electrodes varies widely within an electrode array and also across subjects. The current study evaluated the effects of electrode location in the implanted cochlea (specifically medial-lateral location) on various electrophysiological and psychophysical measures in eleven human subjects. The results demonstrated that some measures of interest, specifically ECAP thresholds, psychophysical detection thresholds, and ECAP amplitude-growth function (AGF) linear slope, were significantly related to the distances between the electrode and mid-modiolar axis (MMA). These same measures were less strongly related or not significantly related to the electrode to medial wall (MW) distance. In contrast, neither the IPG Effect for the ECAP AGF slope or threshold, nor the MPI slopes were significantly related to MMA or MW distance from the electrodes. These results suggest that "within-channel" estimates of neural health such as the IPG Effect and MPI slope might be more suitable for estimating nerve condition in humans for clinical application since they appear to be relatively independent of electrode position.

Improved High-Density Myoelectric Pattern Recognition Control Against Electrode Shift Using Data Augmentation and Dilated Convolutional Neural Network

Abstract: Objective: the objective of this work is to develop a robust method for myoelectric control towards alleviating the interference of electrode shift. M ethods: In the proposed method, a preprocessing approach was first performed to convert high-density surface electromyogram (HD-sEMG) signals into a series of images, and the electrode shift appeared as pixel shift in these images. Next, a data augmentation approach was applied to the training data from just one position (no shift), so as to simulate HD-sEMG images derived from fictitious shift positions. The dilated convolutional neural network (DCNN) was subsequently adopted for classification. Compared to common convolutional neural network, DCNN always contained a larger receptive field that was supposed to be adept at mining wider spatial contextual information in images. This property was further confirmed to facilitate the classification of myoelectric patterns using HD-sEMG. The performance of the proposed method was evaluated with HD-sEMG data recorded by a $\mathbf {10\times 10}$ electrode array placed over forearm extensors of ten subjects during their performance of six wrist and finger extension tasks. Results: Under a variety of actual electrode shift conditions, the proposed method achieved a mean classification accuracy of 95.34%, and it outperformed other common methods. Conclusion: This work demonstrated feasibility and usability of combining data augmentation and DCNN in predicting myoelectric patterns in the context of electrode shifts. Significance: The proposed method is a practical solution for robust myoelectric control against electrode array shifts.

Detection of Extracochlear Electrodes in Cochlear Implants with Electric Field Imaging/Transimpedance Measurements: A Human Cadaver Study.

Abstract: Objectives Extracochlear electrodes in cochlear implants (CI), defined as individual electrodes on the electrode array located outside of the cochlea, are not a rare phenomenon. The presence of extracochlear electrodes frequently goes unnoticed and could result in them being assigned stimulation frequencies that are either not delivered to, or stimulating neurons that overlap with intracochlear electrodes, potentially reducing performance. The current gold-standard for detection of extracochlear electrodes is computed tomography (CT), which is time-intensive, costly and involves radiation. It is hypothesized that a collection of Stimulation-Current-Induced Non-Stimulating Electrode Voltage recordings (SCINSEVs), commonly referred to as "transimpedance measurements (TIMs)" or electric field imaging (EFI), could be utilized to detect extracochlear electrodes even when contact impedances are low. An automated analysis tool is introduced for detection and quantification of extracochlear electrodes. Design Eight fresh-frozen human cadaveric heads were implanted with the Advanced Bionics HiRes90K with a HiFocus 1J lateral-wall electrode. The cochlea was flushed with 1.0% saline through the lateral semicircular canal. Contact impedances and SCINSEVs were recorded for complete insertion and for 1 to 5 extracochlear electrodes. Measured conditions included: air in the middle ear (to simulate electrodes situated in the middle ear), 1.0% saline in the middle ear (to simulate intraoperative conditions with saline or blood in the middle ear), and soft tissue (temporal muscle) wrapped around the extracochlear electrodes (to simulate postoperative soft-tissue encapsulation of the electrodes). Intraoperative SCINSEVs from patients were collected, for clinical purposes during slow insertion of the electrode array, as well as from a patient postoperatively with known extracochlear electrodes. Results Full insertion of the cochlear implant in the fresh-frozen human cadaveric heads with a flushed cochlea resulted in contact impedances in the range of 6.06 ± 2.99 kΩ (mean ± 2SD). Contact impedances were high when the extracochlear electrodes were located in air, but remained similar to intracochlear contact impedances when in saline or soft tissue. SCINSEVs showed a change in shape for the extracochlear electrodes in air, saline, and soft tissue. The automated analysis tool showed a specificity and sensitivity of 100% for detection of two or more extracochlear electrodes in saline and soft tissue. The quantification of two or more extracochlear electrodes was correct for 84% and 81% of the saline and soft tissue measurements, respectively. Conclusions Our analysis of SCINSEVs (specifically the EFIs from this manufacturer) shows good potential as a detection tool for extracochlear electrodes, even when contact impedances remain similar to intracochlear values. SCINSEVs could potentially replace CT in the initial screening for extracochlear electrodes. Detecting migration of the electrode array during the final stages of surgery could potentially prevent re-insertion surgery for some CI users. The automated detection tool could assist in detection and quantification of two or more extracochlear electrodes.

Long-term Intracellular Recording of Optogenetically-induced Electrical Activities using Vertical Nanowire Multi Electrode Array

Abstract: Continuous recording of intracellular activities in single cells is required for deciphering rare, dynamic and heterogeneous cell responses, which are missed by population or brief single-cell recording. Even if the field of intracellular recording is constantly proceeding, several technical challenges are still remained to conquer this important approach. Here, we demonstrate long-term intracellular recording by combining a vertical nanowire multi electrode array (VNMEA) with optogenetic stimulation to minimally disrupt cell survival and functions during intracellular access and measurement. We synthesized small-diameter and high-aspect-ratio silicon nanowires to spontaneously penetrate into single cells, and used light to modulate the cell’s responsiveness. The light-induced intra- and extracellular activities of individual optogenetically-modified cells were measured simultaneously, and each cell showed distinctly different measurement characteristics according to the cell-electrode configuration. Intracellular recordings were achieved continuously and reliably without signal interference and attenuation over 24 hours. The integration of two controllable techniques, vertically grown nanowire electrodes and optogenetics, expands the strategies for discovering the mechanisms for crucial physiological and dynamic processes in various types of cells.

Immediate and 1-Year Outcomes with a Slim Modiolar Cochlear Implant Electrode Array:

Abstract: ObjectiveTo explore the immediate and 1-year outcomes of patients who underwent implantation with the slim modiolar electrode (SME).Study DesignConsecutive case series with chart review.SettingTert...

Fabrication of Parylene-Coated Microneedle Array Electrode for Wearable ECG Device.

Abstract: Microneedle array electrodes (MNE) showed immense potential for the sensitive monitoring of the bioelectric signals by penetrating the stratum corneum with high electrical impedance. In this paper, we introduce a rigid parylene coated microneedle electrode array and portable electrocardiography (ECG) circuit for monitoring of ECG reducing the motion artifacts. The developed MNE showed stability and durability for dynamic and long-term ECG monitoring in comparison to the typical silver-silver chloride (Ag/AgCl) wet electrodes. The microneedles showed no mechanical failure under the compression force up-to 16 N, but successful penetration of skin tissue with a low insertion force of 5 N. The electrical characteristics of the fabricated MNE were characterized by impedance spectroscopy with equivalent circuit model. The designed wearable wireless ECG monitoring device with MNE proved feasibility of the ECG recording which reduces the noise of movement artifacts during dynamic behaviors.

Micro/Nano Electrode Array Sensors: Advances in Fabrication and Emerging Applications in Bioanalysis

Abstract: Due to the rapid development of micro/nano manufacturing techniques and the greater understanding in electrochemical principles and methods, micro/nano electrode array sensing has received much attention in recent years, especially in bioanalysis. This review aims to explore recent progress in innovative techniques for the construction of micro/nano electrode array sensor and the unique applications of various types of micro/nano electrode array sensors in biochemical analysis. Moreover, the new area of smart sensing benefited from miniaturization of portable micro/nano electrode array sensors as well as wearable intelligent devices are further discussed.

Electrode impedance changes after implantation of a dexamethasone-eluting intracochlear array

Abstract: Postoperative inflammation and the formation of fibrotic tissue around the intracochlear electrode array are often held responsible for negative outcomes in cochlear implant recipients. Here we test the effectiveness of intracochlear delivery of dexamethasone via a drug-eluting electrode array in reducing fibrotic tissue formation, assessed via measurement of both monopolar and four-point electrode impedance. Adult guinea pigs were bilaterally implanted with a dexamethasone-eluting array (left ear) and a standard non-eluting array (right ear). Arrays were electrically stimulated daily for 4 weeks, commencing 1 week after implantation, and impedance measured both before and after stimulation. Histological assessment of the tissue was made at the end of the 5-week period. The dexamethasone-eluting array did not reduce monopolar (MP1 + 2) electrode impedance over the course of 5 weeks, and no significant difference was observed in fibrotic tissue, new bone growth, or spiral ganglion neuron density between array types. However, four-point impedance, which provides an indication of the local environment at the neural-tissue interface, was significantly lower in the presence of dexamethasone. A strong relationship was seen between four-point and monopolar impedance for individual electrode arrays, with the exception of the standard array after daily electrical stimulation. This group instead showed a significant correlation between the final four-point impedance measure and percentage of fibrous tissue and new bone growth. In conclusion, this study demonstrated that dexamethasone influences four-point electrode impedance as well as the relationship between fibrotic tissue and impedance, and that both outcomes are shaped by daily electrical stimulation. These results suggest a change occurs at the local tissue-electrode interface in the presence of sustained, intracochlear release of dexamethasone.

Use of intraoperative CT scanning for quality control assessment of cochlear implant electrode array placement.

Abstract: Background: Imaging of cochlear implant (CI) electrode arrays (EAs) consists of intraoperative fluoroscopy to rule out tip fold-over and/or post-operative computerized tomography (CT) if concern ex...

Pre- and post-operative imaging of cochlear implants: a pictorial review.

Abstract: Cochlear implants are increasingly used to treat sensorineural hearing disorders in both children and adults. Pre-operative computed tomography and magnetic resonance imaging play a pivotal role in patient selection, to rule out findings that preclude surgery or identify conditions which may have an impact on the surgical procedure. The post-operative position of the electrode array within the cochlea can be reliably identified using cone-beam computed tomography. Recognition of scalar dislocation, cochlear dislocation, electrode fold, and malposition of the electrode array may have important consequences for the patient such as revision surgery or adapted fitting.

Flexible Electrocorticography Electrode Array for Epileptiform Electrical Activity Recording under Glutamate and GABA Modulation on the Primary Somatosensory Cortex of Rats.

Abstract: Epilepsy is a common neurological disorder. There is still a lack of methods to accurately detect cortical activity and locate lesions. In this work, a flexible electrocorticography (ECoG) electrode array based on polydimethylsiloxane (PDMS)-parylene was fabricated to detect epileptiform activity under glutamate (Glu) and gamma-aminobutyric acid (GABA) modulation on primary somatosensory cortex of rats. The electrode with a thickness of 20 μm has good flexibility to establish reliable contact with the cortex. Fourteen recording sites with a diameter of 60 μm are modified by electroplating platinum black nanoparticles, which effectively improve the performance with lower impedance, obtaining a sensitive sensing interface. The electrode enables real-time capturing changes in neural activity under drug modulation. Under Glu modulation, neuronal populations showed abnormal excitability, manifested as hypsarrhythmia rhythm and continuous or periodic spike wave epileptiform activity, with power increasing significantly. Under GABA modulation, the excitement was inhibited, with amplitude and power reduced to normal. The flexible ECoG electrode array could monitor cortical activity, providing us with an effective tool for further studying epilepsy and locating lesions.

Speech recognition with cochlear implants as a function of the number of channels: Effects of electrode placement

Abstract: This study investigated the effects of cochlear implant (CI) electrode array type and scalar location on the number of channels available to CI recipients for maximum speech understanding and sound quality. Eighteen post-lingually deafened adult CI recipients participated, including 11 recipients with straight electrode arrays entirely in scala tympani and 7 recipients with translocated precurved electrode arrays. Computerized tomography was used to determine electrode placement and scalar location. In each condition, the number of channels varied from 4 to 22 with equal spatial distribution across the array. Speech recognition (monosyllables, sentences in quiet and in noise), subjective speech sound quality, and closed-set auditory tasks (vowels, consonants, and spectral modulation detection) were measured acutely. Recipients with well-placed straight electrode arrays and translocated precurved electrode arrays performed similarly, demonstrating asymptotic speech recognition scores with 8-10 channels, consistent with the classic literature. This finding contrasts with recent work [Berg, Noble, Dawant, Dwyer, Labadie, and Gifford. (2019). J. Acoust. Soc. Am. 145, 1556-1564] that found precurved electrode arrays well-placed in scala tympani demonstrate continuous performance gains beyond 8-10 channels. Given these results, straight and translocated precurved electrode arrays are theorized to have less channel independence secondary to their placement farther away from neural targets.

Direct embedding and versatile placement of electrodes in 3D printed microfluidic-devices.

Abstract: In this paper, we describe how PolyJet 3D printing technology can be used to fully integrate electrode materials into microfluidic devices during the print process. This approach uses stacked printing (separate printing steps and stage drops) with liquid support to result in devices where electrodes and a capillary fluidic connection are directly integrated and ready to use when printing is complete. A key feature of this approach is the ability to directly incorporate electrode materials into the print process so that the electrode(s) can be placed anywhere in the channel (at any height). We show that this can be done with a single electrode or an electrode array (which led to increases in signal). In both cases, we found that a middle electrode configuration leads to a significant increase in the sensitivity, as opposed to more traditional bottom channel placement. Since the electrode is embedded in the device, in situ platinum black deposition was performed to aid in the detection of nitric oxide. Finally, a generator-collector configuration with an opposed counter electrode was made by placing two working electrodes ∼750 μm apart (in the middle of the channel) and a platinum counter electrode at the bottom of the channel. The utility of this configuration was demonstrated by dual electrode detection of catechol. This 3D printing approach affords robust electrochemical detection schemes with new electrode configurations being possible in a manner that also increases the ease of use and transferability of the 3D printed devices with integrated electrode materials.

Hearing Preservation With a New Atraumatic Lateral Wall Electrode.

Abstract: Introduction Many individuals have some residual hearing which should be preserved with cochlear implantation To achieve this goal electrode arrays must fulfil certain design requirements A new thin lateral wall electrode array (HiFocus SlimJ) was systematically designed on the basis of μCT studies of human cochlea anatomy The primary objective of this study was to report on initial retrospective hearing preservation results from a cohort of subjects consecutively implanted with this electrode Secondary objectives were to report on insertion depth and speech perception results for this new array Methods Twenty subjects with considerable residual hearing in low frequencies were consecutively implanted with the SlimJ electrode array The electrode was inserted slowly through the round window and the insertion process was controlled by intracochlear electrocochleography measuring cochlear microphonics through the cochlear implantPostoperative cone beam computed tomography was conducted and precise scalar location and angular insertion depth was estimated following image fusion with the preoperative images Results Low frequency hearing at 1 month postsurgery was preserved within 30 dB HL in 85% of subjects and within 15 dB HL in 50% of subjects Mean angular insertion depth was 393 degrees (SD 62 degrees) with a range from 294 to 520 degrees All electrode contacts in all subjects were identified within scala tympani Conclusion The SlimJ electrode array is easy to handle for atraumatic insertion through the round window, adjusted insertion depth controlled by electrocochleography measurements, and reliable fixation at the posterior tympanotomy Hearing preservation rates are encouraging on the short term We aim to further report on larger data sets and long-term outcomes

Electrophysiological detection of electrode fold-over in perimodiolar cochlear implant electrode arrays: a multi-center study case series.

Abstract: It is important for the surgeon to determine the position of the CI electrode array during and after its placement within the cochlea. Most preferably, this should be within the scala tympani to obtain the best audiological outcome. Thus, misplacement into the scala vestibuli or tip fold-over should be prevented. Since there are different ways to ensure proper positioning of the electrode array within the scala tympani (e.g., intraoperative radiography, electrophysiological recordings), our study was aimed at detecting intraoperative electrophysiologic characteristics to better understand the mechanisms of those electrode tip fold-overs. In a multi-centric, retrospective case–control series, patients with a postoperatively by radiography detected tip fold-over in perimodiolar electrodes were included. The point of fold-over (i.e., the electrode position) was determined and the intraoperative Auto-NRT recordings were analysed and evaluated. Four patients were found to have an electrode tip fold-over (out of 85 implantees). Significant changes of the Auto-NRT recordings were not detected. All tip fold-overs occurred in the most apical part of the electrodes. Cochlear implantation for hearing impaired patients plays a decisive role in modern auditory rehabilitation. Perimodiolar electrode arrays may fold over during the insertion and, hence, could have a negative impact on audiological outcome. Characteristic electrophysiologic changes to possibly predict this were not found in our series.

Development of an active high-density transverse intrafascicular micro-electrode probe

Abstract: Objective. In this work, the development of an active high-density transverse intrafascicular micro-electrode (hd-TIME) probe to interface with the peripheral nervous system is presented. Approach. The TIME approach is combined with an active probe chip, resulting in improved selectivity and excellent signal-to-noise ratio. The integrated multiplexing capabilities reduce the number of external electrical connections and facilitate the positioning of the probe during implantation, as the most interesting electrodes of the electrode array can be selected after implantation. The probe chip is packaged using thin-film manufacturing techniques to allow for a minimally invasive electronic package. Special attention is paid to the miniaturization, the mechanical flexibility and the hermetic encapsulation of the device. Main results. A customized probe chip was designed and packaged using a flexible, implantable thin electronic package (FITEP) process platform. The platform is specifically developed for making slim, ultra-compliant, implantable complementary metal-oxide-semiconductor based electronic devices. Multilayer stacks of polyimide films and HfO2/Al2O3/HfO2 layers deposited via atomic layer deposition act as bidirectional diffusion barriers and are key to the hermetic encapsulation. Their efficacy was demonstrated both by water vapor transmission rate tests and accelerated immersion tests in phosphate buffered saline at 60 °C. Using the hd-TIME probe, an innovative implantation method is developed to prevent the fascicles from moving away when the epineurium is pierced. In addition, by transversally implanting the hd-TIME probe in the proximal sciatic nerve of a rat, selective activation within the nerve was demonstrated. Significance. The FITEP process platform can be applied to a broader range of integrated circuits and can be considered as an enabler for other biomedical applications.

3D Diamond Electrode Array for High-Acuity Stimulation in Neural Tissue

Abstract: Innovations in micro-and nanofabrication technologies enable the manufacture of multielectrode arrays for use in neuromodulation and neural recording. Multielectrode arrays make possible medical implants such as pacemakers, deep-brain stimulators, or visual and hearing aids, to treat numerous neural disorders. An optimal neural interface requires a high density of electrodes to precisely record from and stimulate the nervous system while minimizing the overall size of the array. For example, people with retinal degenerative diseases can benefit from retinal prostheses implanted inside the eye. However, at present the visual acuity provided by such implants is well below the threshold for functional vision, mainly due to the limited spatial resolution. In this work, we present a design of 3D nanostructured conductive diamond electrodes, integrated within a polycrystalline diamond housing, offering a high electrode density and count, which simultaneously satisfies spatial resolution and biocompatibility goals. The array is composed of height adjustable pillar electrodes that are 80 μm in diameter and separated by 150 μm. A holistic characterization of the electrodes was performed and the device tested for stimulation performance in a whole-mounted retina. Electrochemical testing showed impedance of 20 kω and a wide water window of 2.47 V. The pillar structure allows the distance between the electrodes and the retinal ganglion cells to be reduced which is key to more confined stimulation at lower current levels, leading to potentially higher-acuity stimulation without damaging retinal tissue.

Comparison of Perimodiolar Electrodes: Imaging and Electrophysiological Outcomes.

Abstract: Background The perimodiolar CI532 Slim Modiolar electrode has been designed to bring the electrode contacts close to auditory nerve while reducing cochlear trauma during its insertion. It is currently unknown to what extent the electrode position and electrophysiological outcomes of the Slim Modiolar electrode differ from other perimodiolar electrodes. Objectives The objective was to compare the electrode position and electrophysiological outcomes between the CI532 Slim Modiolar and CI512 Contour Advance electrode. Method Forty-six adult patients received a Slim Modiolar or Contour Advance electrode. Electrode types were compared using intraoperative electrode impedances, evoked compound action potential (ECAP) and stapedius reflex thresholds, as well as position parameters from postoperative computed tomography or digital volume tomography images (medial-lateral position, electrode-to-modiolus distance, insertion angle). Results The medial-lateral position indicates a closer modiolar placement of the Slim Modiolar compared with the Contour Advance. Individual electrode contact measurements, however, showed significantly larger electrode-to-modiolus distances and higher ECAP thresholds for the Slim Modiolar in the basal region. On contacts E20-22 the Slim Modiolar is slightly closer to the modiolus compared with the Contour Advance, but this did not result in lower ECAP thresholds. Conclusions Perimodiolar electrodes can vary in their intracochlear position, leading to divergent electrophysiological outcomes. To detect these differences, investigations must be done for each electrode contact rather than using a global factor for the whole electrode array. While the electrode dislocation rate is lower with the Slim Modiolar than with the Contour Advance, electrode-to-modiolus proximity is smaller and ECAP thresholds are lower with the Contour Advance in the basal cochlear region.