Showing papers on "Epileptogenesis published in 1978"
TL;DR: Spontaneous motor seizures similar to those elicited by stimulation were observed in 16 of the 18 kindled subjects, and appear to be a reliable manifestation of long-term amygdaloid kindling.
287 citations
TL;DR: The results of recent experiments using intracellular recording techniques, ion‐specific microelectrodes, and a methodology suitable for studying mammalian cortex in vitro are discussed in terms of cellular phenomena which underlie clinical observations made in epileptic patients.
Abstract: The study of epilepsy serves to emphasize the importance of integrating basic research with clinical data. In this selective review, the results of recent experiments using intracellular recording techniques, ion-specific microelectrodes, and a methodology suitable for studying mammalian cortex in vitro are discussed in terms of cellular phenomena which underlie clinical observations made in epileptic patients. This information has begun to clarify: (1) the changes in neuronal behavior associated with interictal and ictal events; (2) alterations in local ionic microenvironment which occur during focal epileptogenesis; (3) intrinsic control mechanisms which serve to restrict seizure spread; (4) neuronal characteristics which account for the differences in seizure patterns seen in infants and adults; and (5) the possible long-term consequences of recurrent local neuronal hyperexcitability.
31 citations
TL;DR: Data in this study fail to support the hypothesis that decreased levels of taurine in the epileptic focus or in supraspinal structures are causally related to penicillin epileptogenesis.
4 citations