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Erythropoietin-producing hepatocellular (Eph) receptor
About: Erythropoietin-producing hepatocellular (Eph) receptor is a research topic. Over the lifetime, 2068 publications have been published within this topic receiving 120392 citations.
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TL;DR: In this paper, it was shown that ephrin-B2, an Eph family transmembrane ligand, marks arterial but not venous endothelial cells from the onset of angiogenesis.
1,572 citations
TL;DR: The concept of bidirectional signalling has emerged as an important mechanism by which Ephs and ephrins control the output signal in processes of cell–cell communication.
Abstract: Eph receptors constitute the largest family of tyrosine kinase receptors and, together with their plasma-membrane-bound ephrin ligands, have many important functions during development and adulthood. In contrast with most receptor tyrosine kinases, unidirectional signalling can originate from the ephrin ligands as well as from the Eph receptors. Furthermore, the concept of bidirectional signalling has emerged as an important mechanism by which Ephs and ephrins control the output signal in processes of cell–cell communication.
1,161 citations
TL;DR: The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps, and may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system.
Abstract: The Eph receptors are the largest known family of receptor tyrosine kinases. Initially all of them were identified as orphan receptors without known ligands, and their specific functions were not well understood. During the past few years, a corresponding family of ligands has been identified, called the ephrins, and specific functions have now been identified in neural development. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been implicated in pathway selection by axons, the guidance of cell migration, and the establishment of regional pattern in the nervous system. The ligands are anchored to cell surfaces, and most of the functions so far identified can be interpreted as precise guidance of cell or axon movement. This large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system.
1,122 citations
TL;DR: New findings reveal that Eph receptors and ephrins coordinate not only developmental processes but also the normal physiology and homeostasis of many adult organs, and balance of Eph/ephrin function may contribute to a variety of diseases.
1,116 citations
TL;DR: The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression patterns in cancer cells and tumour blood vessels, which suggest important roles for their bidirectional signals in many aspects of cancer development and progression.
Abstract: The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression patterns in cancer cells and tumour blood vessels, which suggest important roles for their bidirectional signals in many aspects of cancer development and progression. Eph gene mutations probably also contribute to cancer pathogenesis. Eph receptors and ephrins have been shown to affect the growth, migration and invasion of cancer cells in culture as well as tumour growth, invasiveness, angiogenesis and metastasis in vivo. However, Eph signalling activities in cancer seem to be complex, and are characterized by puzzling dichotomies. Nevertheless, the Eph receptors are promising new therapeutic targets in cancer.
1,067 citations