Excoecaria agallocha

About: Excoecaria agallocha is a research topic. Over the lifetime, 362 publications have been published within this topic receiving 5042 citations. The topic is also known as: Gewa.

Stereostructure of Excoecarin H, a Novel seco-Labdane-Type Diterpene from Excoecaria agallocha

Abstract: A novel seco-labdane-type diterpene, excoecarin H was isolated from resinous wood of Excoecaria aggallocha collected from Okinawa prefecture. Stereochemistry of the new diterpene was determined on the basis of chemical and physicochemical evidence.

Triterpenoids and steroids from Excoecaria agallocha

Abstract: OBJECTIVE To study the chemical constituents of Excoecaria agallocha L. METHOD The constituents were isolated and purified by repeated column chromatography and their structures were elucidated by spectroscopic analysis. RESULT Six triterpenoids including taraxerone (1), beta-amyrin acetate (2), 3beta-[(2E,4E)-6-oxo-decadienoyloxy]-olean-12-ene (3), taraxerol (4), acetylaleuritolic acid (5), and cycloart-22-ene-3beta, 25-diol (6), and three steroids including beta-sitostenone (7), (24R)-24-ethylcholesta-4,22-dien-3-one (8), and beta-sitosterol (9) were isolated and identified from the stems and twigs of the mangrove plant E. agallocha. CONCLUSION Compounds 5-8 were isolated from E. agallocha for the first time.

Anti-Methicillin Resistant Staphylococcus aureus (MRSA) of Methanol Extract of Mangrove Plants Leaf: Preliminary Report

Abstract: Increasing multidrug resistant (MTDR) in bacteria, in particular Staphylococcus aureus has been becoming worst. Finding new antibiotic source for MTDR is compulsion for scientist and clinicians due to the limitation of the therapeutic option. This research was conducted to investigate the antibacterial activity of methanol extracts of Sonneratia caseolaris, Acanthus ilicifolius, Rhizophora mucronata and Excoecaria agallocha against methicillin resistant, clinical isolates of Staphylococcus aureus using disk diffusion method. The minimum inhibitory concentration (MIC) values of all methanolic mangrove leaves ranged from 6 to 20 mg/mL. The mangrove leaf of Excoecaria agallocha possessed higher anti MRSA potency than the other mangrove plants. It is clear that mangrove leaves especially, E. agallocha leaf has anti MRSA compound. Further purification of active compound from the potent mangrove will be useful for the control of drug resistant strains of S. aureus.

Ethanolic Stem Extract of Excoecaria Agallocha Induces G1 Arrest or Apoptosis in Human Lung Cancer Cells Depending on Their P53 Status

Abstract: Excoecaria agallocha L. is a mangrove widely used as folklore medicine but its anticancer properties have not been evaluated yet. In this study, the ethanol stem extract of this plant exhibited remarkable cytotoxic activities on human lung cancer cell lines in a dose-dependent manner after 48 h of incubation. Analysis of the mechanism of action demonstrated that the extract exerted apoptotic cell death in p53 +/+ cells and G1 arrest in p53 -/- cells. Morphological observation using phase-contrast microscope also displayed apoptotic characteristics in treated p53 +/+ cells such as nuclear blebbing and chromatin condensation. Cell cycle analysis showed G1 arrest caused by the extract in p53 -/- cells. Furthermore, acute exposure to the extract produced a significant regulation of p21, Bcl-2 and Bax protein expression in both these cell lines. Due to its potent cytotoxic effect on lung cancer cell lines, it is strongly suggested that the extract could be further developed as an anticancer drug.