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Showing papers on "Fagonia cretica published in 2013"


Journal Article
TL;DR: It was found that the mean values exhibited that Peganum harmala excelled in high moisture contents, fat, carbohydrate, protein than Fagonia cretica and Tribulus terrestris L.
Abstract: The aim of this study was to find out the nutritional value of some selected plants of family Zygophyllaceae and Euphorbiaceae which are traditionally used in different parts of Pakistan. The five plants Fagonia cretica L., Peganum harmala L., Tribulus terrestris L., Chrozophora tinctoria (L.) Raf. and Ricinus communis L., were collected from Peshawar and Attock Hills during winter, 2009. In the present study it was found that the mean values exhibited that Peganum harmala excelled in high moisture contents, fat, carbohydrate, protein than Fagonia cretica and Tribulus terrestris L. Peganum harmala might be considered a good nutritive plant followed by Fagonia cretica that contained the highest fibre. The Tribulus terrestris also contained maximum protein and gross energy. The differences found in the proximate composition of these medicinal plants might be attributed to the habitat, environment and time of harvest. Chrozophora tinctoria and R. communis revealed variation in various analyzed biochemicals. The mean values showed that C. tinctoria had high moisture, ash, fibre and carbohydrate than its counterpart R. communis. Ricinus communis had more protein, fats and gross energy than C. tinctoria. The cultivation of R. communis should be encouraged on large scale for the development of biodiesel that will help people. Its seeds can be helpful for pharmaceutical, insecticidal and food industries.

14 citations


Journal Article
TL;DR: The statistical analysis revealed that 10g and 20g extracts of all the tested plants significantly inhibited the growth of Lemna minor with significant differences, and Peganum harmala showed the highest insects mortality followed by Fagonia cretica at the same dose.
Abstract: The statistical analysis revealed that 10g and 20g extracts of all the tested plants significantly inhibited the growth of Lemna minor with significant differences. The plants means were non-significant while the interaction between extracts and plants was significant. Fagonia cretica, Peganum harmala, Tribulus terrestris, Chrozophora tinctoria and Ricinus communis caused significant growth inhibition of Lemna minor in all the dilutions. The interaction between plants and dilution was non-significant. Among the three plants extracts, Peganum harmala showed the highest insects mortality followed by Fagonia cretica at the same dose. Tribulus terrestris showed the lowest mortality of Tribolium castaneum. All the doses (5 to 20%) of the plant extracts showed significant differences of mortality of T. castaneum as compared to control. The highest dose mean (12.8%) was shown by P. harmala, while the lowest dose mean was shown by T. terrestris.

9 citations


Journal ArticleDOI
18 Nov 2013
TL;DR: Results revealed that Fagonia cretica exhibited a dose-dependent relaxant activity on rabbit intestine similar to that produced by standard adrenaline with, Emax, EC50 and EC50 as mean ± S.E.M, and compared statistically.
Abstract: The aim of this study was to verify the pharmacological effect(s) of the Fagonia cretica linn (Zygophyllaceae) ethanolic extract and to determine the mechanism(s) underlay its action using isolated rabbit intestine. The cumulative dose-response curves of the Fagonia cretica extract and standard adrenaline were constructed using different doses ranged (10 -3 - 10 2 µg/ml), and (10 -9 - 10 -5 M) alone, and in the presence of a single dose of a blocker, then the values of EC50, Emax and pA2 were determined as mean ± S.E.M, and compared statistically. The adrenergic non-selective blockers, phentolamine and propranolol in concentrations of (10 -8 and 10 -5 M) were used to elucidate the exact mechanism mediating the relaxant effect of the ethanolic extract of Fagonia cretica linn. Results revealed that Fagonia cretica exhibited a dose-dependent relaxant activity on rabbit intestine similar to that produced by standard adrenaline with, Emax= [56.4 ± 7.5], [7.2 ± 4.3] and EC50= [0.12 ± 0.27], [9.85 ± 1.6] x 10 -6

6 citations


01 Jan 2013
TL;DR: In this article, aqueous extract of Fagonia cretica L. (Zygophyllaceae) whole plant was evaluated in male Wistar albino rats.
Abstract: Antihyperlipidemic activity of aqueous extract of Fagonia cretica L. (Zygophyllaceae) whole plant was evaluated in male Wistar albino rats. After induced hyperlipidaemia by high fat diet, the aqueous extract of Fagonia cretica L. 250 & 500mg/kg (AEFC) and standard drug atorvastatin were administered orally to different group of rats for two times at an interval of 12 hours and continued for 15 days. After termination of the study, all group animals were sacrificed and lipid profile such as Total Cholesterol (TC), Triglycerides (TG), Low Density Lipoproteins (LDL) and High Density Lipoproteins was estimated. High fat diet showed significant increase in LDL, TG, TC and a significant decrease in HDL in serum. The aqueous extract of Fagonia cretica L. and atorvastatin treated groups showed significantly increased HDL levels and decreased TC, TG and HDL-LDL ratio. The Aqueous extract of Fagonia cretica L. has showed significant antihyperlipidemic activity.

1 citations


Book ChapterDOI
01 Jan 2013

Journal Article
TL;DR: This study proves that HAEFC has anxiolytic, sedative and hypnotic activities, similar to that of standard drug diazepam.
Abstract: Article history Received 28/09/2313 Available online To study the Neuro-pharmacological screening by hydro alcoholic extract of Fagonia cretica Linn (Family: Zygophyllaceae) (HAEFC). The phytochemical constituents of and some neuropharmacological activity of HAEFC was evaluated in Male swiss albino mice weighing 20-25g, employing various models elevated plus maze test (EPZ), exploratory behavior (hole board apparatus ) (HBA) for anxiolytic effect and locomotor activity using actophotometer, muscle relaxant activity using rota-rod apparatus (RRA) for sedative- hypnotic activity. The results of preliminary phytochemical analysis had showed the presence of alkaloids, flavonoids, saponins, tannins, glycosides, triterpenoids in the whole plant hydroalcoholic extract of Fagonia cretica Linn. The HAEFC showed LD50 at a dose of 2000 mg/kg body weight p.o in mice. HAEFC had showed a significant (P<0.01 for 200 mg/kg and P<0.05 for 100 mg/kg) increase in number of entries and time spent in open arm, where as it significantly (P<0.01 for 200 mg/kg and P<0.05 for 100 mg/kg) decreased the no of entries and time spent in closed arm in EPZ when compared to control group. HAEFC had also showed a significant (P<0.01 for 200 mg/kg and P<0.05 for 100 mg/kg) decrease in no of head dips for exploratory behavior in HBA , no of counts in for locomotor in actophotometer and time spend on revolving rod on RRA for sedative and hypnotic effect when compared to control group. The effects were similar to that of standard drug diazepam. Our study proves that HAEFC has anxiolytic, sedative and hypnotic activities.

Book ChapterDOI
01 Jan 2013