Topic
Fagonia cretica
About: Fagonia cretica is a research topic. Over the lifetime, 59 publications have been published within this topic receiving 519 citations.
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TL;DR: FCE treatment was found to be significantly diminished the massive damage in the genetic constituents and dangerous alterations in biochemical parameters with respect to BPA treatment alone, and enhancements were increased by increasing the dose level of FCE.
Abstract: Fagonia cretica L. was considered to be a medical plant that was used for the treatment of different diseases, so the current study was designed to clarify whether Fagonia cretica extract (FCE) can avoid Bisphenol A (BPA)-induced genotoxicity and biochemical alterations in rats. Sixty-three male rats were used in this experiment. These animals were distributed into nine groups (seven rats each): negative control, control of corn oil, positive control that were administrated BPA in corn oil (10 mg/kg. b.w.) for 3 weeks, three protection groups received the same dose of BPA in corn oil at the same period together with FCE (3.3, 4.2 and 5.0 g/kg) daily for 3 weeks, and three therapeutic groups received FCE alone at the same doses for 10 days after cessation of BPA treatment. Genetic and biochemical studies were conducted. Genetic studies involved DNA comet assay, micronucleus test, chromosome examination, and mitotic index analysis. Biochemical studies involved liver function (AST, ALT, ALph, and Bilirubin), kidney function (urea and creatinine contents), protein profile, MDA, and endogenous antioxidative system (SOD, CAT, and ACHE) as well as nucleic acid (DNA and RNA) contents in the liver, kidney, and brain tissues. The results demonstrated that the treatment with BPA induced a significant elevation in genetic abnormalities and deleterious effects in biochemical parameters in relation to untreated control. FCE treatment was found to be significantly diminished the massive damage in the genetic constituents and dangerous alterations in biochemical parameters with respect to BPA treatment alone. These enhancements were increased by increasing the dose level of FCE. Moreover, better results were clarified by utilizing FCE as a protective agent than its utilization as a therapeutic agent especially by using the high dose (5.0 g/kg), in which mostly genetic and biochemical alterations were observed to be restored towards natural levels. These findings clarified a new insight into the protective effect of FCE in minimizing BPA-induced genotoxicity and biochemical changes in rats detecting the capability of such medicinal plant for alleviating the adverse effect of BPA.
1 citations
01 Jan 2014
TL;DR: The study targeted to determine the effects of ethanolic extracts of Fagonia cretica linn plant on many biochemical parameters in Albino rats Khartoum, Omdurman, and Shendi towns in Sudan during January – February, 2011.
Abstract: The study targeted to determine the effects of ethanolic extracts of Fagonia cretica linn plant on many biochemical parameters in Albino rats Khartoum, Omdurman, and Shendi towns in Sudan during January – February, 2011. To determine the medicinal properties of the plant and to study the effects of the plant on many biochemical parameters. Different methods were adopted to achieve the objectives of this study, including Harborne methods for extraction. A total of 30 young adult Wistar rats, of age of 8-12 weeks were obtained from the Sudan National Centre for Research, Khartoum Sudan. These rats were divided into 4 groups, three groups are study groups ,where the 4th group was control group. The rats were fed standard rat food and water d libitum, were maintained at standard laboratory conditions. Ethical approval had been obtained from Omdurman Islamic University, Faculty of Pharmacy, and department of Pharmacology, under the number (01/0/2013) .Before the experiment was beginning; rats were fasted overnight for 14 – 16 hours. Group C, which was the control group, received 10 ml/kg body wt. distilled water, orally, throughout the study period while Groups 1, 2 and 3 were orally administered single, daily doses, 100, 300 and 600 mg/kg of body weight, respectively of the Fagonia cretica ethanolic extract dissolved in distilled water 1gm/10ml for 14 days using acute oral toxicity 425 protocol.
1 citations
27 Jun 2015
TL;DR: In this paper, the antimicrobial potential and phytochemical profile of Eremostachys laciniata plant was evaluated to look into possible natural therapy agents, which revealed that Fagonia cretica have an excellent anti-bacterial activity and can be used for disease therapy.
Abstract: The aim of the present research was to evaluate the antimicrobial potential and phytochemical profile of Eremostachys laciniata plant to look into possible natural therapy agents. The shade-dried whole plant material of Eremostachys laciniata was soaked in methanol for 10 days. The powdered drug was extracted with 80 % methanol three times and filtered at room temperature. The filtrate was evaporated in rotary to get a dark-greenish residue (extract), which was further suspended in water and partitioned successively with n-hexane, chloroform, distill water and n-butanol to obtain nhexane- soluble, chloroform-soluble, distill water-soluble, n-butanol soluble and aqueous fractions, respectively. Different fractions (chloroform, n-hexane, butanol, water and ethyl acetate) of the plant were tested against various bacterial strains namely E.coli, S.aureus, S.typheae, P.auriginosa.The extracted fractions of the plant exhibit moderate activities showing 9mm to 18mm inhibition against different strains of bacteria as compared to the control, which gave maximum inhibition upto 29mm. The Eremostachys laciniata was found to be good source of alkaloids, flavonoids, tennins, resins, carbohydrate, starch, proteins, glycosides, coumarin, terponides, steroids and saponine. Anthranol glycosides were absent in the plant. The above results revealed that Fagonia cretica have an excellent anti-bacterial activity and can be used for disease therapy.
1 citations
TL;DR: The synergistic utilization of phytochemicals derived from B. lyceum may potentially provide protection against B. melitensis via well diffusion method for their antibacterial activity.
Abstract: Background Brucellosis is an economically important zoonotic disease caused by the gram negative bacteria belonging to the genus Brucella. Medicinal plants are well known for a wide variety of potential antimicrobial agents that can be used as anti-microbial drugs. Method In the present study, crude ethanol and methanol extracts of local plants (Berberies lyceum and Fagonia cretica) were tested in vitro against Brucella melitensis via well diffusion method for their antibacterial activity. In in-silico study, phytochemicals previously identified in the selected plants were docked with homology model of the cytotoxic factor malate synthase G (MSG) highly conserved among Brucella spp., in Molecular Operating Environment (MOE) to predict a potential drug against B. melitensis. Molecular dynamic simulation was performed to predict the stability of MSG through MOE. Result Ethanolic crude extracts of B. lyceum showed maximum zone of inhibition (32.5 mm) followed by methanolic extracts (30 mm), while ethanolic extracts of F. cretica showed zone of inhibition (29 mm) followed by methanolic extracts (27.5 mm). In silico screening predicted phytic acid as the most potent inhibitor followed by jehlumine, barbamine, oxyberberine and sindamine. Conclusion The synergistic utilization of phytochemicals derived from B. lyceum may potentially provide protection against B. melitensis.
1 citations
Journal Article•
TL;DR: The ethanolic extract of Fagonia cretica in doses of (100, 300 and 600) mg/kg/body weight) has different effects on the major blood cells in rats after the study period, but in general it is concluded that it raises the main blood parameters.
Abstract: Objectives: To determine the effects of ethanolic extract of fagonia cretica linn on different hematological parameters, in albino rats, in Sudan (January – February) 2011. Materials & Methods: Different methods were adopted in this study; the Harborne extraction method was applied. A total of (30), young adult Wistar rats of age (8-12) weeks, weighing (42.6 – 72.2) grams, maintained at standard laboratory conditions, obtained from Sudan NCR. Rats were divided into (4) groups, (3) x (7) rats (study groups), and control group (9) rats. All rats were sacrificed for inspection, and safety of internal organs. Ethical approval had been obtained. Before experiments started, rats were fasted overnight for (14 – 16) hours. the control group (C), received orally (10) ml/kg distilled water, while groups (1,2,3) were orally receiving single, daily doses ( 100, 300 and 600) mg/kg of body weight of the extract in distilled water (1 g/10 ml) respectively, for (14) days using acute oral toxicity (425) protocol [36]. (CBC) blood samples were collected in (EDTA) tubes - from the rat’s eyes using non-heparinized capillary tubes. The assay was done at Shendi University using (Shenzhen Mindray BC-3000 Plus Auto Hematology Analyzer). Results: The ethanolic extract of Fagonia cretica in doses of (100, 300 and 600) mg/kg/body weight) has different effects on the major blood cells in rats after the study period (14 - days) compared to the control group. Conclusion: Statistical analysis for evaluation of the extract affects different variant hematological parameters, but in general it is concluded that it raises the main blood parameters.
1 citations