Fagonia cretica

About: Fagonia cretica is a research topic. Over the lifetime, 59 publications have been published within this topic receiving 519 citations.

Further saponins from Fagonia cretica.

Abstract: Three triterpenoid saponins including two new ones were isolated and identified from the aerial parts of Fagonia cretica. The new saponins were characterized as 3-O-[beta-D-xylopyranosyl(1-->2)alpha-L-arabinopyranosyl]27-hydroxyoleanolic acid 28-O-[beta-D-glucopyranosyl(1-->6)beta-D-glucopyranosyl]ester and 3 beta-O-[beta-D-xylopyranosyl(1-->2)alpha-L-arabinopyranosyl] olean-12-en-27-al-28-oic acid 28-O-[beta-D-glucopyranosyl(1-->6)beta-D-glycopyranosyl] ester. The structures were determined by spectral analyses. The NMR assignments were made by means of HOHAHA, 1H-1H COSY, HMQC, HMBC spectra and NOE studies.

Proximate analysis of plants of family Zygophyllaceae and Euphorbiaceae during winter

Abstract: The aim of this study was to find out the nutritional value of some selected plants of family Zygophyllaceae and Euphorbiaceae which are traditionally used in different parts of Pakistan. The five plants Fagonia cretica L., Peganum harmala L., Tribulus terrestris L., Chrozophora tinctoria (L.) Raf. and Ricinus communis L., were collected from Peshawar and Attock Hills during winter, 2009. In the present study it was found that the mean values exhibited that Peganum harmala excelled in high moisture contents, fat, carbohydrate, protein than Fagonia cretica and Tribulus terrestris L. Peganum harmala might be considered a good nutritive plant followed by Fagonia cretica that contained the highest fibre. The Tribulus terrestris also contained maximum protein and gross energy. The differences found in the proximate composition of these medicinal plants might be attributed to the habitat, environment and time of harvest. Chrozophora tinctoria and R. communis revealed variation in various analyzed biochemicals. The mean values showed that C. tinctoria had high moisture, ash, fibre and carbohydrate than its counterpart R. communis. Ricinus communis had more protein, fats and gross energy than C. tinctoria. The cultivation of R. communis should be encouraged on large scale for the development of biodiesel that will help people. Its seeds can be helpful for pharmaceutical, insecticidal and food industries.

Intrinsic Bio-Enhancer Entities of Fagonia cretica for Synthesis of Silver Nanoparticles Involves Anti-Urease, Anti-Oxidant and Anti-Tyosinase Activity

Abstract: Objective: Evaluating the bio-reducing activity and various potential, annotates the biological entitties of Fagonia cretica. Method: By fractionating the crude extract with different ethanol-water fraction mixture. This substantiates the reduction potential for the biological synthesis of AgNPs, its antioxidant, anti-urease and anti-Tyrosinase activity. Results: UV-visible spectra confirm the bio-reducing potential for Ag NPs with the optimized 50% ethanol-water fraction mixture. Transmission electron microscopy (TEM) confirmed the round shaped AgNPs with an average size of 16 nm in optimized 50% fraction mixture. Further evaluating Ethanol-water fraction with 90% and 70% of plant extract showed more potentials for Anti-Tyrosinase and Anti-urease activity. Moreover, diluted 30% fraction exhibits two folds higher Anti-oxidant and Anti urease activity. Conclusion: Overall, this work showed that 50% Ethanol-water fraction has potentially active molecules (among all fractions) primarily involved in bio-reducing potential of Ag NPs and enzymatic assay while 90% mixture proved to be least active. This study suggested electing the optimum mixture fraction of 50% ethanol-water in order to screen the bioactive compounds and to inculcate their activity status for clinical trials.

Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert anti-inflammatory properties by modulating platelet aggregation and VEGF, COX-2 and VCAM gene expressions in rat hippocampal slices subjected to ischemic reperfusion injury.

Abstract: Summary: The formation of cerebral edema and central nervous system (CNS) inflammation are a result of cerebral ischemia. Pharmacological strategies to reverse or minimize acute ischemic brain injury include "antiplatelet" agents, anticoagulants, and thrombolytics. However, these therapies have either exhibited undesirable side effects or are not cost-effective for the common people. We report here the neuroprotective effects of three herbs Rubia cordifolia (RC), Fagonia cretica linn (FC) and Tinospora cordifolia (TC) as potent anti-inflammatory agents in view of their ability to downregulate the expressions of COX2 and VCAM genes and upregulate VEGF expression and inhibit platelet aggregation induced by multiple agonists in hypoxic-ischemic hippocampal slices. All the three herbs exhibited appreciable anti-inflammatory properties. Industrial relevance: The above work will lead to development of new anti-inflammatory drugs with less toxic preparations and has the potential to generate employment among people who will go farming of such medicinal plants.