Showing papers on "Fatty acid-binding protein published in 1981"
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TL;DR: It is concluded that ligandin and protein A can enhance the rate of intracellular of their ligands by an order of magnitude or more and that this could make the hepatocyte several times more efficient in metabolizing these ligands.
Abstract: A theory is presented that deals with the involvement of the intracellular binding proteins ligandin and aminoazodye-binding protein A (otherwise known as Z-protein or fatty-acid-binding protein) on the uptake and intracellular transport and metabolism of their ligands. Equations are derived that combine steady-state diffusional fluxes of small molecules that are (a) free in the aqueous phase of the cell, (b) bound to the two proteins and (c) partitioned into intracellular membranes, for model systems that resemble conditions in the rat hepatocyte. These equations are then combined with expressions for the enzyme-catalysed metabolic reactions undergone by these small molecules to assess the influence of diffusion rats on the overall metabolic rates. It is concluded that ligandin and protein A can enhance the rate of intracellular of their ligands by an order of magnitude or more and that this could make the hepatocyte several times more efficient in metabolizing these ligands. Various ways of testing this theory are discussed.
108 citations
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TL;DR: No fatty acid binding protein was observed in the six elasmobranchs studied and the results with crustaceans were ambiguous, so the aspects of functional evolution of serum albumin are discussed.
Abstract: 1. 1. A technique is described to study the binding of fatty acids to albumin in serum by use of thin-layer gel filtration. 2. 2. The presence of a protein which binds [14C]oleate is established in higher vertebrates, teleosts and a petromyzone. 3. 3. No fatty acid binding protein was observed in the six elasmobranchs studied and the results with crustaceans were ambiguous. 4. 4. The aspects of functional evolution of serum albumin are discussed.
48 citations
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TL;DR: The effect of added dietary ethyl palmitate or ethyl linoleate on hepatic lipogenic enzymes and the amount of hepatic fatty acid binding protein was examined in meal-fed rats to discuss the possible role of fatty acid biding protein in the regulation of lipogenesis by dietary fat.
15 citations