Showing papers on "Fatty acid-binding protein published in 1982"
TL;DR: The abundance of FABP, its importance in the cytosolic binding of endogenous as well as exogenous fatty acids, and its demonstrated correlation with rates of hepatocyte fatty acid utilization provide additional evidence for its relationship to the cellular metabolism of long chain fatty acids.
265 citations
TL;DR: In isolated rat fat cells the fatty acid-binding protein was demonstrated to be involved in the uptake and esterification of long-chain fatty acids and constituted evidence for a potential role of this protein in the fatty acids metabolism of adipocytes.
51 citations
Journal Article•
TL;DR: Both fractions from rat liver were more effective than albumin in the exchange of palmitic acid to particulate material and this and perhaps other cytosolic protein/s participate in cellular fatty acid transport.
Abstract: The presence of two fractions with affinity for 1-14C palmitic acid was demonstrated in the 105,000 x g supernatant of rat liver homogenate by Sephadex G-75 gel filtration. The lowest molecular weight fraction was identified as fatty acid binding protein as judged by its relative elution volume in Sephadex G-75, its binding characteristics to sulfobromophthalein and palmitic acid binding inhibition by flavaspidic acid. Discontinuous sucrose gradient was used to study palmitic acid exchange from these cytosolic fractions to microsomes and mitochondria. Both fractions from rat liver were more effective than albumin in the exchange of palmitic acid to particulate material. Palmitic acid was exchanged from fatty acid binding protein to liposomes. This and perhaps other cytosolic protein/s participate in cellular fatty acid transport.
5 citations
Journal Article•
TL;DR: With immunological techniques it has been shown that the FABP has no organ-specificity and no immunological relation to the lipoproteins of the serum, and a physiological function in the intracellular translocation of the fatty acids in different rat organs was inferred.
Abstract: The endogenous lipid pattern of a fatty acid binding protein (FABP; synonym: "Z"-protein) in the cytosolic fraction of rat liver involves besides "free" fatty acids also phospholipids and mono-, di- and triacylglycerols. The relation between "free" fatty acids and the sum of all other lipids is nearly 1. In consequence of this result a correction of the idea is necessary that the FABP specifically binds only fatty acids. With immunological techniques it has been shown that the FABP has no organ-specificity and no immunological relation to the lipoproteins of the serum. A high content of fat in the diet (25% fat) compared with a low fat content of the diet (1% fat) led to an increase of the concentration of FABP in the cytosols of different rat organs (liver, intestinal mucosa, fat tissue and heart). Therefore a physiological function in the intracellular translocation of the fatty acids in different rat organs was inferred.
3 citations