Topic
Fatty acid-binding protein
About: Fatty acid-binding protein is a research topic. Over the lifetime, 1721 publications have been published within this topic receiving 81530 citations. The topic is also known as: FABP.
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TL;DR: It is suggested that intracellular lipid-binding proteins such as I-FABP may enhance the membrane transport of lipophilic xenobiotics and facilitate drug access to the enterocyte cytoplasm and cy toplasmic organelles.
36 citations
TL;DR: Fatty acid-binding proteins are found in extraordinary abundance in cells of mammalian tissues that are actively involved in the uptake or utilization of fatty acids, such as intestine, liver, and heart.
Abstract: Fatty acid-binding proteins are found in extraordinary abundance in cells of mammalian tissues that are actively involved in the uptake or utilization of fatty acids, such as intestine, liver, and heart. They are small proteins, and different tissues contain distinct types. They are typically considered to be the intracellular counterpart of serum albumin and are thought to play an extensive role in cellular lipid homeostasis.
36 citations
TL;DR: A fatty acid binding protein has been purified from etiolated Avena sativa seedlings and is capable of binding long-chain fatty acids and their CoA-esters.
36 citations
TL;DR: The data supports the fact that FABP1 might be an important mediator participating in fatty acid metabolism and energy balance and demonstrates that hypertriglyceridemia and low HDL-cholesterol were significantly correlated to serum FABp1 levels.
Abstract: Background
Liver fatty acid–binding protein (FABP1) plays an inconclusive role in adiposity. We investigated the association of serum FABP1 levels with obesity and insulin resistance in Chinese young people under 30 years old.
36 citations
TL;DR: It is likely that the concept of fatty acid transport will continue to converge, incorporating the individual functions of the wide variety of fatty acids transporters into an integrated physiologic framework with relevance to a number of diseases.
Abstract: Purpose of review The aim of the present review is to summarize recent developments in the area of regulation of fatty acid transport. Recent findings While controversy still exists regarding the contribution of passive diffusion versus protein-mediated fatty acid transport, both processes are now widely accepted. With the recent identification of an increasing number of putative fatty acid transporters, emphasis has been placed on regulation including fatty acid transport function of the protein, and also possible associated functions (acylCoA synthase activity and vectorial channelling to intracellular processing). Deciphering these issues has been facilitated through the use of loss-of-function (such as knockout) and gain-of-function (cell transfectants and transgenic mice) models. Summary It is likely that our concept of fatty acid transport will continue to converge, incorporating the individual functions of the wide variety of fatty acid transporters into an integrated physiologic framework with relevance to a number of diseases.
36 citations