Topic
Fatty acid-binding protein
About: Fatty acid-binding protein is a research topic. Over the lifetime, 1721 publications have been published within this topic receiving 81530 citations. The topic is also known as: FABP.
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TL;DR: The catabolic system, translocating then beta-oxidizing fatty acids in the mitochondria and considered as the major energy generator in the heart, was shown in the present study to be strongly regulated by fatty acid-binding protein (FABP), a self-aggregated and exclusive protein for the binding and transport of fatty acid in the cardiac cell cytoplasm.
32 citations
TL;DR: The specific localization of B-FABP, but not the other FABPs, in Kupffer cells, and its rapid decrease after peritoneal injection of lipopolysaccharide suggest the intimate involvement of B to FABP in K upffer cells in the inflammatory reaction, probably through mediation of n-3 polyunsaturated fatty acids, which are strong binders of B
Abstract: Brain-type fatty acid-binding protein (B-FABP) was localized in Kupffer cells of liver of postnatal day 10 (P10) and older mice in immunolight and electron microscopy as well as by in situ hybridization histochemistry. The immunoreaction products were localized in the cytoplasmic matrix but not within the nucleus. After peritoneal injection of lipopolysaccharide (LPS), the immunoreaction for B-FABP decreased markedly in Kupffer cells at 1 h postinjection and thereafter gradually recovered to the preinjection level by 24 h postinjection, although no decrease in the mRNA expression was detected in Northern blotting throughout the course after the injection. The specific localization of B-FABP, but not the other FABPs, in Kupffer cells, and its rapid decrease after LPS injection suggest the intimate involvement of B-FABP in Kupffer cells in the inflammatory reaction, probably through mediation of n-3 polyunsaturated fatty acids, which are strong binders of B-FABP.
32 citations
32 citations
TL;DR: Ex-FABP could represent a stress protein physiologically expressed in tissues where active remodelling is taking place during development and in tissues characterized by an acute phase response due to pathological conditions and it is suggested that during endochondral bone formation other responses characteristic of a local inflammatory status, such as gelatinase production and angiogenic factor secretion, are "physiologically" activated.
32 citations
TL;DR: The FABP1 T94A variant represents an altered/reduced function mutation resulting in TG accumulation and is associated with nonalcoholic fatty liver disease and reduced ability of fenofibrate to lower serum triglycerides to target levels.
Abstract: Although human liver fatty acid-binding protein (FABP1) T94A variant has been associated with nonalcoholic fatty liver disease and reduced ability of fenofibrate to lower serum triglycerides (TG) t...
32 citations