Topic
Fatty acid-binding protein
About: Fatty acid-binding protein is a research topic. Over the lifetime, 1721 publications have been published within this topic receiving 81530 citations. The topic is also known as: FABP.
Papers published on a yearly basis
Papers
More filters
TL;DR: Changes in FABP concentration indicate involvement of this protein in the regulation of fatty acid metabolism within the cell in response to high carbohydrate and high fat diets.
20 citations
TL;DR: Carnitine palmitoyltransferase-I expression seemed to be induced earlier than 2,4-dienoyl- CoA reductase and fatty acid binding protein, and not later than the peroxisomal fatty acyl-CoA oxidase, and delta9-desaturase showed a more delayed response.
20 citations
TL;DR: It is proposed that the accumulation of fatty acid, specific ligand of Ex‐FABP, in the cell microenvironment is responsible of heart cell death, and it is suggested that Ex‐ FABP may act as a survival protein by playing a role as scavenger for fatty acids.
Abstract: Ex-FABP is an extracellular fatty acid binding protein, expressed during chicken embryo development in cartilage, muscle fibers, and blood granulocytes. Transfection of chondrocytes and myoblasts with anti-sense Ex-FABP cDNA results in inhibition of cell proliferation and apoptosis induction. Ex-FABP expression is dramatically enhanced by inflammatory stimuli and in pathological conditions. In this paper, by in situ whole mount and immunohistochemistry analysis we show that, at early developmental stage, Ex-FABP is diffuse in all tissues of chick embryos. Particularly high level of transcript and protein are expressed in the heart. During acute phase response (APR) induced by endotoxin LPS injection, a marked increase of Ex-FABP mRNA was observed in embryos, highest Ex-FABP expression being in heart and liver. To investigate in vivo the biological role of Ex-FABP, we have directly microinjected chicken embryos with antibody against Ex-FABP. Almost 70% of chicken embryos died and the target tissue was the heart. We detected in heart of the treated embryos a significant increase of apoptotic cells and high level of fatty acids. We propose that the accumulation of fatty acid, specific ligand of Ex-FABP, in the cell microenvironment is responsible of heart cell death, and we suggest that Ex-FABP may act as a survival protein by playing a role as scavenger for fatty acids.
20 citations
TL;DR: It is proposed that lipocalin Ex-FABP represents a stress protein physiologically expressed in tissues where active remodelling is taking place during development and also present in tissues characterized by a stress response due to pathological conditions.
Abstract: Extracellular Fatty Acid Binding Protein (Ex-FABP) is a 21 kDa lipocalin, expressed during chicken embryo development in hypertrophic cartilage, in muscle fibres and in blood granulocyte. The protein selectively binds with high affinity fatty acids, preferably long chain unsaturated fatty acids in chondrocyte and myoblast cultures Ex-FABP expression is increased by inflammatory-agents and repressed by anti-inflammatory-agents. In adult cartilage, Ex-FABP is expressed only in pathological conditions such as in dyschondroplastic and osteoarthritic chicken cartilage. We propose that lipocalin Ex-FABP represents a stress protein physiologically expressed in tissues where active remodelling is taking place during development and also present in tissues characterized by a stress response due to pathological conditions.
20 citations
TL;DR: This review describes how a group of small, homologous, intracellular mammalian lipid-binding proteins and their genes have been ‘exploited’ over the last few years to address a number of questions in fields as diverse as biophysics and cell and developmental biology.
Abstract: This review describes how a group of small, homologous, intracellular mammalian lipid-binding proteins and their genes have been ‘exploited’ over the last few years to address a number of questions in fields as diverse as biophysics and cell and developmental biology. Their usefulness as model systems has now been recognized although their precise physiological role(s) remains a mystery.
20 citations