Topic
Fetus
About: Fetus is a research topic. Over the lifetime, 21567 publications have been published within this topic receiving 646380 citations. The topic is also known as: foetus & fœtus.
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TL;DR: In this article, the authors proposed that preterm labor in the setting of infection results from the actions of proinflammatory cytokines secreted as part of the fetal and/or maternal host response to microbial invasion.
514 citations
Book•
01 Jan 1989
TL;DR: The Prenatal Diagnosis of Structural Heart Disease and Doppler Ultrasound Assessment of Blood Flow, and the Endocrinology of Pregnancy: Clinical Characteristics and Management.
Abstract: Basic Genetics and Patterns of Inheritance. Prenatal Diagnosis of Genetic Disorders. Normal Development. Maternal-Fetal Interface- Immunologic Interactions. Gestational Changes of the Reproductive Tract and Breast. Physiology of the Myometrium. Puerperium. The Breast and Physiology of Lactation. Maternal Nutrition. Effects of Chemical and Environmental Agents. Social and Illicit Drug Use in Pregnancy. Woman Battering in Pregnancy. General Principles and Application of Ultrasound. The Prenatal Diagnosis of Structural Heart Disease. Doppler Ultrasound Assessment of Blood Flow. Fetal Breathing and Body Movements. Fetal Cardiovascular Physiology. Placental Respiratory Gas Exchange and Fetal Oxygenation. Fetal Heart Rate. Fetal Cardiac Arrhythmias: Diagnosis and Therapy. Fetal Biophysical Assessment By Ultrasound. Fetal Acid-Base Balance. Percutaneous Fetal Blood Sampling. Fetal Therapy: Medical and Surgical Approaches. The Endocrinology of Pregnancy. Significance of Amniotic Fluid Meconium. Fetal Lung Development, Tests for Maturation, Induction of Maturation, And Treatment. Recurrent Abortion. Cervical Incompetence. Immunologic Disorders. Characteristics of Parturition. Preterm Labor and Delivery. Post-Term Pregnancy. Normal and Abnormal Labor. Intrauterine Growth Restriction . Multiple Gestation: Incidence, Etiology and Inheritance. Multiple Gestation: Clinical Characteristics and Management. Placenta Previa and Abruptio Placentae. Amniotic Fluid Disorders. Premature Rupture of the Membranes. Maternal and Fetal Infections. Human Immunodeficiency Virus. Hemolytic Disease (Erythroblastosis Fetalis). Nonimmune Hydrops. Cardiovascular and Renal Adaptation to Pregnancy. Cardiac Diseases. Thromboembolic Disease. Pregnancy Related Hypertension. Renal Disorders. Intensive Care Monitoring of the Critically Ill Pregnant Patient. Pulmonary Disorders. Maternal Hematologic Disorders. Diabetes in Pregnancy. Thyroid Disease in Pregnancy. Other Endocrine Disorders of Pregnancy. Gastrointestinal Disease in Pregnancy. Diseases
508 citations
TL;DR: An important role is suggested for maternal sources of TGF-beta 1 during development and, more generally, evidence for maternal rescue of targeted gene disruption in the fetus is provided.
Abstract: Maternal sources of transforming growth factor-beta 1 (TGF-beta 1) are shown here to contribute to the normal appearance and perinatal survival of TGF-beta 1 null newborn mice. Labeled TGF-beta 1 crossed the placenta and was recovered intact from various tissues after oral administration to mouse pups. TGF beta-1 protein was also detected in cells recovered from breast milk. In immunohistochemical analyses, TGF-beta 1 null embryos and null newborn pups born to TGF-beta 1 heterozygotes stained positive for TGF-beta 1, whereas those born to a null female were negative and had severe cardiac abnormalities. These results suggest an important role for maternal sources of TGF-beta 1 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus.
508 citations
TL;DR: In this article, 32P-labeled complementary DNA probes encoding human and mouse Sm-C/IGF-I and human IGF-II were used in Northern blot hybridization to analyse rat SmC/I and insulin-like growth factor II mRNAs in poly(A+) RNAs from intestine, liver, lung, and brain of adults and fetal rats between day 14 and 17 of gestation.
507 citations
TL;DR: Dolly was the first sheep cloned and developed from the nuclei of fully differentiated adult cells, rather than from theuclei of early embryonic cells.
Abstract: Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. The first offspring to develop from a differentiated cell were born after nuclear transfer from an embryo-derived cell line that had been induced to become quiescent. Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required for development to term. The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to become quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
494 citations