Topic
Fish oil
About: Fish oil is a research topic. Over the lifetime, 9887 publications have been published within this topic receiving 367953 citations. The topic is also known as: fish oils & Fish oil.
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TL;DR: The differences observed in lipid and fatty acid deposition suggested that genetics affected lipid deposition and metabolism and that breeding programmes could select for fish that retained more n−3 LC-PUFA in their flesh, particularly when fed diets low in these fatty acids.
106 citations
TL;DR: In this article, the effect of α-tocopherol on the oxidation of unrefined mackerel oil samples (recovered by solvent extraction), was investigated at 30, 4 and −40°C over a period of 66 days by monitoring changes in peroxide values, conjugated diene content as well as levels of thiobarbituric acid reactive substances.
106 citations
TL;DR: The hypothesis that part of the protective effect of fish oil against atherosclerosis might be due to an altered macrophage phenotype and function is supported by the reduced expression of ICAM-1 and MSR-A on macrophages from mice fed on a fish oil-rich diet.
106 citations
TL;DR: The dietary treatment of fish oil resulted in a substantial inhibition of leukotriene B4 production by the peripheral blood polymorphonuclear leukocytes in vitro, and in eight patients there was a modest improvement in their psoriasis, the principal effects being a diminution of erythema and scaling.
Abstract: Ten patients with psoriasis resistant to conventional topical treatment were given dietary supplements of fish oil, providing approximately 12 g of eicosapentaenoic acid daily for a period of at least 6 weeks. In eight patients there was a modest improvement in their psoriasis, the principal effects being a diminution of erythema and scaling. The dietary treatment resulted in a substantial inhibition of leukotriene B4 production by the peripheral blood polymorphonuclear leukocytes in vitro. The discrepancy between the high degree of inhibition of leukotriene B4 synthesis and the modest therapeutic effect suggests that leukotriene B4 is not the only mediator involved in the development of the psoriatic lesion. Furthermore, the in vivo cutaneous levels of leukotriene B4 might not have been inhibited to the same extent as the polymorphonuclear leukocyte levels in vitro. Further studies on the use of fish oil supplements, both on their own and in conjunction with other forms of treatment in psoriasis are warranted. It will also be important to determine whether the altered profile of 5-lipoxygenase products found in the blood is also seen in the skin.
105 citations
TL;DR: The data suggest the dietary n − 3 LC-PUFA requirement of juvenile cobia can be largely satisfied by DHA, and that EPA, if required, is required only in trace amounts.
105 citations