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Fish oil

About: Fish oil is a research topic. Over the lifetime, 9887 publications have been published within this topic receiving 367953 citations. The topic is also known as: fish oils & Fish oil.


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Journal ArticleDOI
TL;DR: The ability of conjugated linoleic acid to prevent endotoxin-induced growth suppression and Splenocyte blastogenesis was increased by conjugations, and anorexia was prevented from endotoxin injection.

331 citations

Journal ArticleDOI
TL;DR: Evidence is seen for a fairly consistent, but modest, benefit of marine n-3 PUFAs on joint swelling and pain, duration of morning stiffness, global assessments of pain and disease activity, and use of non-steroidal anti-inflammatory drugs.
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of the joints and bones. The n-6 polyunsaturated fatty acid (PUFA) arachidonic acid (ARA) is the precursor of inflammatory eicosanoids which are involved in RA. Some therapies used in RA target ARA metabolism. Marine n-3 PUFAs (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) found in oily fish and fish oils decrease the ARA content of cells involved in immune responses and decrease the production of inflammatory eicosanoids from ARA. EPA gives rise to eicosanoid mediators that are less inflammatory than those produced from ARA and both EPA and DHA give rise to resolvins that are anti-inflammatory and inflammation resolving, although little is known about these latter mediators in RA. Marine n-3 PUFAs can affect other aspects of immunity and inflammation relevant to RA, including dendritic cell and T cell function and production of inflammatory cytokines and reactive oxygen species, although findings for these outcomes are not consistent. Fish oil has been shown to slow the development of arthritis in animal models and to reduce disease severity. A number of randomised controlled trials of marine n-3 PUFAs have been performed in patients with RA. A systematic review included 23 studies. Evidence is seen for a fairly consistent, but modest, benefit of marine n-3 PUFAs on joint swelling and pain, duration of morning stiffness, global assessments of pain and disease activity, and use of non-steroidal anti-inflammatory drugs.

329 citations

Journal ArticleDOI
TL;DR: Dietary FO reduces body fat mass and stimulates lipid oxidation in healthy adults and, when adjusted for lean body mass, resting metabolic rate was unchanged.
Abstract: OBJECTIVE: To investigate whether the substitution of fish oil for visible fats in a control diet (52% carbohydrates, 16% protein, 32% fat; P:S 0.2) influences body fat mass and substrate oxidation in healthy adults. DESIGN: Six volunteers (5 men; 23±2 y; BMI: 21.9±1.6) were fed a control diet (C) ad libitum during a period of three weeks and, 10–12 weeks later, the same diet where 6 g/d of visible fat were replaced by 6 g/d of fish oil (FO) for another three weeks. RESULTS: Energy intakes (IKA-calorimeter) were unchanged. Body fat mass (Dual-energy X-ray absorptiometry) decreased with FO (−0.88±0.16 vs−0.3±0.34 kg; FO vs C; P<0.05). When adjusted for lean body mass (Ancova), resting metabolic rate (indirect calorimetry) was unchanged. Basal respiratory quotient decreased with FO (0.815±0.02 vs 0.834±0.02; P<0.05) and basal lipid oxidation increased with FO (1.06±0.17 vs 0.87±0.13 mg kg−1 min−1; P<0.05). CONCLUSION: Dietary FO reduces body fat mass and stimulates lipid oxidation in healthy adults.

326 citations

Journal ArticleDOI
TL;DR: Sixty percent of fish oil can be replaced by a blend of different vegetable oils without affecting gilthead seabream health, however, if single vegetable oil is used to replace 60% ofFish health can be affected in terms of immunosuppression or stress resistance.

325 citations

Journal ArticleDOI
TL;DR: The data provide further confirmation for the concept that fish oil–derived fatty acids reduce the risk of acute coronary events, however, a high mercury content in fish could attenuate this protective effect.
Abstract: Background—Previous findings concerning the serum levels of fish-derived (n-3) fatty acids and coronary heart disease are inconsistent The purpose of this study was to investigate the association between the serum n-3 end-product fatty acids docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and eicosapentaenoic acid and the risk of acute coronary events in middle-aged men Methods and Results—We studied this association in the Kuopio Ischaemic Heart Disease Risk Factor Study, a prospective population study in Eastern Finland Subjects were randomly selected and included 1871 men aged 42 to 60 years who had no clinical coronary heart disease at baseline examination A total of 194 men had a fatal or nonfatal acute coronary event during follow-up In a Cox proportional hazards’ model adjusting for other risk factors, men in the highest fifth of the proportion of serum DHA+DPA in all fatty acids had a 44% reduced risk (P=0014) of acute coronary events compared with men in the lowest fifth Men in th

325 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023259
2022552
2021308
2020347
2019326
2018360