Topic
Flavanone
About: Flavanone is a research topic. Over the lifetime, 1965 publications have been published within this topic receiving 54729 citations. The topic is also known as: flavanones.
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TL;DR: Phytochemical investigation of the root bark of U. davidiana var.
30 citations
TL;DR: In this paper, a study was conducted to isolate and to investigate antimutagenic activity of some flavanones from Kaempferia rotunda (Zingiberaceae), which has traditionally used in abdominal pain, sputum laxative, wounds and diarrhea colic disorder.
30 citations
TL;DR: The results showed that the His-tagged protein (AaF3H) catalyzed naringenin to dihydrokaempferol in the present of Fe(2+) and implied that AaF 3H was a potential target for regulation of flavonoids biosynthesis in Artemisia annua through metabolic engineering.
30 citations
TL;DR: It was found that the hydroxylation on position 3′ of flavonol significantly improves the binding affinity for HSA, and the values of log10(Ka) are proportional to the number of binding sites (n), which confirms the method used here is suitable to study the interaction between Citrus flavanones and HSA.
Abstract: Much of the bioactivities of Citrus flavanones significantly appear to impact blood and microvascular endothelial cells. It is essential to investigate the interaction between Citrus flavanones and serum albumin to verify the effect of flavanone structures on the distribution and transportation in blood. The interactions between flavonoids and proteins have attracted great interest among researchers. The work in here mainly concerns about the binding interaction between Citrus flavanones and human serum albumin (HSA) in vitro. The methoxylation of tangeretin improved the affinity for HSA by 100 times. The 2,3-double bond in conjugation with a 4-oxo group plays an important role for the affinity for HSA. The affinity of apigenin for HSA is about 10,000-times higher than that of naringenin. It was found that the hydroxylation on position 3' of flavonol significantly improves the binding affinity for HSA. The affinity of quercetin (3', 4') for HSA is about 100-times higher than that of kaempferol (4'). The hydroxylation on position 3' of flavone slightly improves the binding affinity for HSA. The affinity of luteolin for HSA is about 1.38-times higher than that of apigenin. The values of log10(Ka) are proportional to the number of binding sites (n), which confirms the method used here is suitable to study the interaction between Citrus flavanones and HSA.
30 citations
TL;DR: Two new flavanones were isolated from the roots of Euchresta formosana in addition to four known Flavanones (xambioona, euchrestaflavanones A, B and C) and a pterocarpan (maackiain), and by spectroscopic analysis, the structures of euchrenones a5 and a6 were determined to be 7-hydroxy-8-γ,γ-dimethyl-allyl and 5
30 citations