Flavanone

About: Flavanone is a research topic. Over the lifetime, 1965 publications have been published within this topic receiving 54729 citations. The topic is also known as: flavanones.

Functional Analysis of an Uridine Diphosphate Glycosyltransferase Involved in the Biosynthesis of Polyphenolic Glucoside in Tea Plants (Camellia sinensis).

Abstract: Polyphenols are one of the largest groups of compounds that confer benefits to the health of plants and humans. Flavonol glycosides are a major ingredient of polyphenols in Camellia sinensis. Flavonol-3-O-glycosides are characteristic astringent taste compounds in tea infusion. A polyphenolic glycosyltransferase (CsUGT72AM1) belonging to cluster IIIb was isolated from the tea plant. The full-length cDNA of CsUGT72AM1 is 1416 bp. It encodes 472 amino acids with a calculated molecular mass of 50.92 kDa and an isoelectric point of 5.21. The recombinant CsUGT72AM1 protein was expressed in Escherichia coli and exhibited catalytic activity toward multiple flavonoids and coniferyl aldehyde. The enzyme assay indicated that rCsUGT72AM1 could perform glycosidation of flavonols or coniferyl aldehyde in vitro to form 3-O-glucoside or 4-O-glucoside, respectively. Interestingly, this enzyme also had activities and performed multisite glycosidation toward flavanones. The consistent products were confirmed to be naringenin-7-O-glucoside and -4'-O-glucoside by the nuclear magnetism assay. In addition, in the enzyme assay with cyanidin as the substrate, the results suggested that the glycosylated activity of CsUGT72AM1 was remarkably inhibited by a high concentration of anthocyanins. The above results indicate that CsUGT72AM1 may be involved in the metabolism of flavonol, flavanone, anthocyanin, and lignin.

Use of flavones and flavonoids against the UV-induced decomposition of dibenzoylmethane and its derivatives

Abstract: Use of flavone derivatives and flavanone derivatives, in particular flavonoids for stabilizing cosmetic or dermatologically acceptable substances, the chemical formula of which includes the structural moiety of dibenzoylmethane, against the decomposition caused by UV radiation.

Enzymatic synthesis of novel antioxidant flavonoids by Escherichia coli cells expressing modified metabolic genes involved in biphenyl catabolism

Abstract: The bpha1(2072)A2A3A4 gene cluster codes for a modified biphenyl dioxygenase holoenzyme with broad substrate specificity. In the previous report, we have shown the biotransformation of flavone, flavanone, 6-hydroxyflavone and 6-hydroxyflavanone by Streptomyces lividans cells carrying bphA1(2072)A2A3A4. In the present study, we successfully biotransformed chalcone and 7-hydroxyisoflavone, which are categorized with other groups of flavonoids, by using recombinant Escherichia coli cells expressing the same genes. We also biotransformed various flavonoids by E. coli cells expressing the bphB (dihydrodiol dehydrogenase) gene in addition to the bphA1(2072)A2A3A4 genes. Flavone, flavanone, 6-hydroxyflavone, 6-hydroxyflavanone, chalcone, and 7-hydroxyisoflavone, which were used as substrates, were converted with high efficiency to their corresponding diols, whose structures were determined by HREI-MS, 1 H NMR and 13 C NMR data. The antioxidative activity of these generated diol compounds was markedly higher than that of the substrates used.