Topic
Flavanone
About: Flavanone is a research topic. Over the lifetime, 1965 publications have been published within this topic receiving 54729 citations. The topic is also known as: flavanones.
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TL;DR: In this paper, a series of citrus flavonoids were evaluated for α-amylase and α-glucosidase inhibitory activities in vitro and the results indicated that the inhibitory capacities of flavanone glycosides were greater than those of polymethoxy flavones.
Abstract: A series of citrus flavonoids were evaluated for α-amylase and α-glucosidase inhibitory activities in vitro. The inhibitory capacities of flavanone glycosides were greater than those of polymethoxy flavones for α-amylase. Naringin exhibited the most potent α-glucosidase inhibitory activity with IC50 0.55 μ.M and was about 196.83 times more active than acarbose. Poncirin led to a 43-fold improvement in α-amylase inhibition over acarbose. The double-reciprocal (Lineweaver-Burk) plot confirms a competitive inhibition mode towards α-amylase and α-glucosidase activities. The inhibition activity was significantly lowered when citrus flavonoids were pre-incubated with starch. The binding site for naringin, poncirin, hesperidin, tangeretin in α-amylase showed a polar contact numbers, respectively, of 47, 54, 51, and 44 more than that involving acarbose. The hydrogen bonds formed between nobilitin and the key residue of Lys506 of α-glucosidase, namely Asn475:N-A:Lys506:O, might provide its extra affinity when compared to tangeritin. These findings provided a strong and rational reason to establish the selected citrus flavonoids capability as a therapeutic target for postprandial hyperglycaemia modulation.
20 citations
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20 citations
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TL;DR: In this article, a new flavanone was isolated from the chloroform extract of the roots of Tephrosia maxima along with maxima isoflavone J and t.
20 citations
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TL;DR: Flavonoid levels of seven sorghum genotypes grown in four locations in Texas, USA were evaluated to assess the relative genotype, environment and genotype × environment effects.
20 citations
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TL;DR: From the fresh leaves of Lindera umbellata Thunb, a new flavanone, named linderatone, was isolated by chemical and spectroscopic means as discussed by the authors.
Abstract: From the fresh leaves of Lindera umbellata Thunb. a new flavanone, named linderatone, was isolated. Its structure was established to be 1 by chemical and spectroscopic means.
20 citations