Topic
Flavanone
About: Flavanone is a research topic. Over the lifetime, 1965 publications have been published within this topic receiving 54729 citations. The topic is also known as: flavanones.
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TL;DR: The present study identified two new C-methyl flavanones, 5, 7, 3', 5'-tetrahydroxy-6, 8-di-C- methyl flavanone and 5, 4'-dihydroxyl-8- C-methylflavanone-7-O-β-D-glucopyranoside, and one new flavonoid glycoside.
16 citations
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TL;DR: The present observations suggest the need to reveal the mechanism by which CYP1A1 expression is modified by flavonoid for risk assessment, since CYP 1A1 activates environmental carcinogenic polycyclic hydrocarbons and flavonoids are major constituents in food.
Abstract: The present study examined modifications of β-naphthoflavone (β-NF)-induced cytochrome P450 1A1 (CYP1A1) expression by flavonoids in mouse hepatocytes in primary culture. Some flavonoids (apigenin, chrysin, flavone, flavanone, galangin, luteolin, and naringenin) by themselves induced CYP1A1 mRNA expression, especially flavone which was even more effective than β-NF. The effect on β-NF-induced CYP1A1 mRNA expression was varied, namely additive, suppressive, or both. An additive effect was observed after combined treatment with flavanone, naringenin, and chrysin, whereas kaempferol, myricetin, and quercetin decreased CYP1A1 levels. Apigenin, chrysin, galangin, luteolin, and morin synergistically enhanced β-NF-induced CYP1A1 expression at 24 h, but considerably suppressed it at 9 h. The structure-activity relationship of flavonoids affecting CYP1A1 expression as inducers or inhibitors is discussed. The present observations suggest the need to reveal the mechanism by which CYP1A1 expression is modified by flavonoids for risk assessment, since CYP1A1 activates environmental carcinogenic polycyclic hydrocarbons and flavonoids are major constituents in food.
16 citations
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TL;DR: In this paper, a novel flavonoid, apigenin 7-(3″-acetyl-6″-E -p -coumaroylglucoside), and one novel flavanone, naringenin 7(3″ -acetyl -6″ -E - p -lgoside) were isolated from aerial parts of Blepharis ciliaris.
16 citations
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TL;DR: In the course of studying the components from the roots of Sophora flavescens, eight new unusual biflavonoids consisting of a flavanone fused with a dihydrochalcone skeleton were isolated.
16 citations
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TL;DR: In this article, 5,7-Dihydroxy-6,5′-dimethoxy-3′,4′-methylenedioxyflavanone has been isolated for the first time from Agave americana.
16 citations