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Flavanone

About: Flavanone is a research topic. Over the lifetime, 1965 publications have been published within this topic receiving 54729 citations. The topic is also known as: flavanones.


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Journal ArticleDOI
TL;DR: The following flavonoids have been isolated from propolis and identified: acacetin (I), 7,4′-dimethoxyflavone (II), kaempferide (III), rhamnocitrin (IV), 5,7-dihydroxy-3, 4′-Dihydroxymethyl-7,4''-dimethyl-dimethyltoxyflavanone (V), 3,5-diamethyltoxoxy-7.4''dimethyltoxoxyflavinone (VI),
Abstract: The following flavonoids have been isolated from propolis and identified: acacetin (I), 7,4′-dimethoxyflavone (II), kaempferide (III), rhamnocitrin (IV), 5,7-dihydroxy-3,4′-dihydroxyflavone (V), 3,5-dihydroxy-7,4′-dimethoxyflavone (VI), (−)-pinostrobin (VII), and (−)-5-hydroxy-7,4′-dimethoxyflavanone (VIII).

15 citations

Journal ArticleDOI
TL;DR: This study provides theoretical evidence that the eriodictyol has an absorbance in the UV-A and UV-B region of the electromagnetic spectrum and therefore can be used as a potential UV filter in sunscreen lotions and other cosmetic products.
Abstract: A computational analysis of UV filtering and radical scavenging capacity of a flavanone, Eriodictyol has been performed under DFT-B3LYP/6–31+ G (d, p). Eriodictyol is nontoxic and nonirritant bitter masker commonly used in the wine industry. It has been reported that the flavanones were widely acceptable for photoprotection due to its potential UV filtering and radical scavenging capacity. This study provides theoretical evidence that the eriodictyol has an absorbance in the UV-A and UV-B region of the electromagnetic spectrum and therefore can be used as a potential UV filter in sunscreen lotions and other cosmetic products. The major transitions in the UV–Visible spectrum of Eriodictyol are between HOMO and HOMO-1 with LUMO level and are well explained by NBO-NLMO tool in G09 software. In addition to this, Eriodictyol is a potent antioxidant than that of the most commonly studied Quercetin. The most active site in the compound is 3′ position and is confirmed by NPA, NBO and pKa value analysis. The lowest energy conformer of Eriodictyol contains a Hydrogen bond between carbonyl oxygen (O2) and H30. This is confirmed by the highest value of interaction energy between lone pairs of O2 and σ* of O3– H30. Both the two lone pairs of O2 interacts with the σ* of O3-H30. This decreases the bond order of 5 OH and at the same time it restricts the hydrogen transfer from this position to form a radical. Similarly, the lone pair of O5 (3′ position) interacts with H33 resulting in the low bond order value and consequently less favorable for radical formation. These results indicate that the BDE values follow the order 3′

15 citations

Journal ArticleDOI
TL;DR: Results indicate that CYP2A6.25 possessed new substrate specificity toward flavonoids, which was not found in the wild‐type CYP 2A6 and was not metabolized by wild‐ type CYP1.1.
Abstract: CYP 2A6 is a human enzyme that metabolizes many xenobiotics including coumarin, indole, nicotine and carcinogenic nitrosamines. The gene for CYP2A6 is polymorphic. There are few data available to clarify the relationship between P450 genetic variants and the metabolism of materials in food. The CYP 2A6 wild-type protein and 13 mutants (CYP2A6.1, CYP2A6.2, CYP2A6.5, CYP2A6.6, CYP2A6.7, CYP2A6.8, CYP2A6.11, CYP2A6.15, CYP2A6.16, CYP2A6.17, CYP2A6.18, CYP2A6.21, CYP2A6.23 and CYP2A6.25) were co-expressed with NADPH-cytochrome P450 reductase in E. coli. The hydroxylase activities toward 7-ethoxycoumarin, coumarin, safrole, flavanone and hydroxyflavanone were examined. Ten types of CYP2A6 variants except for CYP2A6.2, CYP2A6.5 and CYP2A6.6 showed Soret peaks (450 nm) typical of P450 in the reduced CO-difference spectra and had 7-ethoxycoumarin O-deethylase activities. CYP2A6.15 and CYP2A6.18 showed higher activities for safrole 1′-hydroxylation than CYP2A6.1. CYP2A6.25 and CYP2A6.7 had lower safrole 1′-hydroxylase activities. CYP2A6.7 had lower flavanone 6- and 2′-hydroxylase activities, whereas CYP2A6.25 had higher 6-hydroxylase activity and lower 2′-hydroxylase activity. Hydroxyflavanone was metabolized by CYP2A6.25, but was not metabolized by wild-type CYP2A6.1. These results indicate that CYP2A6.25 possessed new substrate specificity toward flavonoids. Copyright © 2012 John Wiley & Sons, Ltd.

15 citations

Journal ArticleDOI
TL;DR: In this article, a principal component analysis (PCA) based algorithm for the analysis and identification of flavonoids classes based on Fourier Transform Infrared spectroscopy (FTIR) spectrum was introduced.
Abstract: Flavonoid is one of the bioactive compounds that are currently used in pharmaceutical and medicinal industries due to their health benefit. The focus of current research is mainly on the extraction and isolation of bioactive compounds; however non to date has explored on the identification of flavonoids classes under the Fourier Transform Infrared spectroscopy (FTIR). This gap presents an opportunity for the application of statistical analysis which can identify the distinct wavenumbers range of flavone, flavanone and flavonol for their characterization in the FTIR spectrum. Development of algorithm based on principal component analysis (PCA) for the analysis and identification of flavonoids classes based on FTIR spectrum was introduced. Based on the results, five wavenumbers ranges have been identified as the distinct characteristics of flavonol, flavone and flavanone hence used for their identification.

15 citations

Journal ArticleDOI
TL;DR: By means of nanosecond laser photolysis and steady-state photo-lysis at room temperature, it was concluded as follows: (1) Both the lowest excited triplet states of flavanone and flavone with mixed n£ ∗ -£ £ ∗ character abstract a hydrogen atom from ethanol generating the solute and solvent radicals as discussed by the authors.
Abstract: By means of nanosecond laser photolysis and steady-state photolysis at room temperature, it is concluded as follows: (1) Both the lowest excited triplet states of flavanone and flavone with mixed n£ ∗ -££ ∗ character abstract a hydrogen atom from ethanol generating the solute and solvent radicals. (2) The radical species of flavanone is undoubtedly its ketyl yielding the pinacol-type isomers and the solvent adduct. (3) The ketyl radical of flavone is indistinguishable from the enol-benzyl-type radical but the photoproducts formed from the latter radical (or from the corresponding keto-benzyl-type radical) are obtained.

14 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202355
2022145
202165
202049
201944
201848