Topic
Flavanone
About: Flavanone is a research topic. Over the lifetime, 1965 publications have been published within this topic receiving 54729 citations. The topic is also known as: flavanones.
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TL;DR: A group of flavones, isoflavones, flavanones, and chalcones was subjected to small-scale biotransformation studies with the Gram-negative Stenotrophomonas maltophilia KB2 strain in order to evaluate the capability of this strain to transform flavonoid compounds and to investigate the relationship between compound structure and transformation type.
Abstract: A group of flavones, isoflavones, flavanones, and chalcones was subjected to small-scale biotransformation studies with the Gram-negative Stenotrophomonas maltophilia KB2 strain in order to evaluate the capability of this strain to transform flavonoid compounds and to investigate the relationship between compound structure and transformation type. The tested strain transformed flavanones and chalcones. The main type of transformation of compounds with a flavanone moiety was central heterocyclic C ring cleavage, leading to chalcone and dihydrochalcone structures, whereas chalcones underwent reduction to dihydrochalcones and cyclisation to a benzo-γ-pyrone moiety. Substrates with a C-2-C-3 double bond (flavones and isoflavones) were not transformed by Stenotrophomonas maltophilia KB2.
14 citations
TL;DR: 16 bioactive MRAs from Millettia pulchra Kurz var-laxior (Dunn) Z.Wei, also called Yulangsan as a famous Zhuang medicine showed to have NQO1 inducing activity, and compounds 4 and 14 interact with N QO1 at Gly 149, Gly 150, Phe 106, Typ 105 and His 161, revealed by molecular docking studies.
14 citations
01 Jan 2000
TL;DR: The superoxide anion radical (O2-) scavenging ability of aqueous extracts from honeybush tea, as affected by species and fermentation, and phenolic compounds from fermented C. sessiliflora, was evaluated as discussed by the authors.
Abstract: 1 Abstract
The superoxide anion radical (O2-) scavenging ability of aqueous extracts from honeybush tea, as affected by species and fermentation, and phenolic compounds from fermented C. intermedia, was evaluated. Unfermented C. sessiliflora showed the strongest O2- scavenging ability. Fermentation significantly (P ≤ 0.05) decreased the O2- scavenging ability of the different species. A strong structure-activity relationship was illustrated by the relative O2- scavenging efficacy of the phenolic compounds. The flavone luteolin and the flavanone eriodictyol showed excellent O2- scavenging activity compared to the flavanones, hesperidin and hesperetin. The isoflavone formononetin and coumestan medicagol were not effective scavengers of this radical.
14 citations
TL;DR: Two coumestanes were isolated for the first time from seedlings of Soja hispida as mentioned in this paper, one compound was identified as coumeestrol, and the other compound, sojagol, is a new coumeester the structure of which was established as 7-hydroxy-5′,5′-dimethyl-6′-oxa-12,13-cyclohexenocoumestane (IV).
14 citations
TL;DR: Among the six flavanones, 3, 5, and 6 were marginally cytotoxic in a human tumor cell line panel and elucidated from detailed 2D NMR analyses.
Abstract: As part of a study on antitumor agents from rainforest plants, two new flavanones, buceracidin A (1), 5,2‘-dihydroxy-3-methoxy-6,7-(2‘ ‘,2‘ ‘-dimethylchromene)flavanone, and buceracidin B (2), 5,2‘-dihydroxy-6,7-(2‘ ‘,2‘ ‘-dimethylchromene)flavanone, were isolated together with four known prenylated flavanones, minimiflorin (3), 3-hydroxyminimiflorin (4), 3-methoxyminimiflorin (5), and mundulinol (6), from Bucida buceras. The structures of buceracidins A and B were elucidated from detailed 2D NMR analyses. Among the six flavanones, 3, 5, and 6 were marginally cytotoxic in a human tumor cell line panel.
14 citations