Flavanone

About: Flavanone is a research topic. Over the lifetime, 1965 publications have been published within this topic receiving 54729 citations. The topic is also known as: flavanones.

Effect of different flavonoids on collagen synthesis in human fibroblasts.

Abstract: In this study, we discovered that flavonoids belonging to the subclasses: (flavanone, flavone, and flavonol) display differential effects on the synthesis of collagen in human dermal fibroblasts. At 80 μg/ml flavonoids quercetin-3,3′,4′, 5,7-pentahydroxyflavone, 3-methyl quercetin, and 7-hydroxyflavone significantly decreased the total protein concentration which was a direct consequence of their cytotoxic effect, while naringenin exhibited no effect on total collagen and total protein concentration. Quercetin-3,3′4′,7-tetramethyl ether, 4′-hydroxyflavanone, flavanone, and fisetin significantly decreased collagen concentration while morin, rutin, and chrysin increased collagen concentration without changing the overall protein concentration. The initial screening performed in this study enables the identification of compounds that exert significant effects on fibroblast function and show potential as starting material for pharmaceutical preparations targeted against various disorders centered around disturbed collagen metabolism.

Isolation of Two New Antiinflammatory Biflavanoids from Sarcophyte piriei

Abstract: Two new flavano flavanone glycosides, diinsininol (1) and diinsinin (2), have been isolated from the rhizome of Sarcophyte piriei, together with one known flavanone glycoside, naringenin 5-glucoside. Their structures were elucidated on spectroscopic evidence as 5,7,3',4'-tetrahydroxyflavanyl-7-O-beta-glucosyl-(4 beta-8;2 beta-O-7)-eriodictyol (1) and 5,7,3',4'-tetrahydroxyflavanyl-7-O-beta-glucosyl-(4 beta-8;2 beta-O-7)-naringenin (2), respectively. The compounds were tested for their ability to inhibit prostaglandin synthesis, with 1 and 2 giving IC50 values of 9.20 mu M and 13.14 mu M, respectively, and in the inhibition of platelet-activating-factor-induced exocytosis, IC50 values of 49 and 39 mu M.

Low molecular weight polyphenols in leaves of Eucalyptus camaldulensis, E. globulus and E. rudis

Abstract: Ether soluble polyphenols from leaves of Eucalyptus camaldulensis, E. globulusand E. rudis have been studied. The phenolic aldehyde vanillin, the phenolic acids gallic, protocatechuic and ellagic acids, some flavonol glycosides (rutin, quercetin-3-arabinoside, quercetin-3,7-dirhamnoside, quercitrin, kaempferol-3-arabinoside and their aglycones), one flavanone (naringenin) and two flavones (luteolin and apigenin) were identified and quantified. Some ellagitannins, flavonols and flavanones were recognized according to their ultra-violet spectra. E. camaldulensis and E. rudis showed the highest concentrations and varieties of flavonol glycosides, whilst E. globulus was characterized by high concentrations of ellagitannins. © 1997 John Wiley & Sons, Ltd.

Cytotoxic chalcones and flavonoids from the leaves of Muntingia calabura

Abstract: Two new dihydrochalcones, 2',4'-dihydroxy-3'-methoxydihydrochalcone, (-)-3'-methoxy-2',4',beta-trihydroxydihydrochalcone, a new flavanone, (2 S)-(-)-5'-hydroxy-7,3',4'-trimethoxyflavanone, and a new flavonol derivative, muntingone, along with sixteen known compounds, were isolated from the leaves of Muntingia calabura. The structures of these new compounds were determined using spectral analyses including extensive 2D NMR data. Among the isolates, (2 S)-5'-hydroxy-7,3',4'-trimethoxyflavanone, 4'-hydroxy-7-methoxyflavanone, 2',4'-dihydroxychalcone, and 2',4'-dihydroxy-3'-methoxychalcone exhibited cytotoxicity (IC (50) values < 4 microg/mL) against P-388 and/or HT-29 cell lines in vitro.

Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study.

Abstract: cope Orange juice contains flavanones including hesperidin and narirutin, albeit at lower concentrations as compared to orange fruit. Therefore, we compared bioavailability and colonic catabolism of flavanones from orange juice to a 2.4-fold higher dose from fresh oranges. Methods and results Following a randomized two-way cross-over design, 12 healthy subjects consumed a test meal comprising either fresh oranges or pasteurized orange juice, delivering 1774 and 751 μmol of total Citrus flavanones, respectively. Deglucuronidated and desulfated hesperetin, naringenin, and the flavanone catabolites 3-(3′-hydroxy-4′-methoxyphenyl)propionic acid, 3-(3′-hydroxyphenyl)hydracrylic acid, 4-hydroxyhippuric acid, and hippuric acid were quantitated in 24-h urine by UHPLC-MS/MS. Differences in urinary hesperetin excretion were found to be nonsignificant (p = 0.5209) both after consumption of orange fruit (21.6 ± 8.0 μmol) and juice (18.3 ± 7.2 μmol). By analogy, postprandial flavanone catabolite excretions were highly similar between treatments. Excretion of 3-(3′-hydroxy-4′-methoxyphenyl)propionic acid was inversely related to that of hesperetin, illustrating the catabolite/precursor relationship. Conclusion Despite 2.4-fold higher doses, excretion of flavanones from ingested fresh orange fruit did not differ from that following orange juice consumption, possibly due to a saturation of absorption or their entrapment in the fiber-rich matrix of the fruit.