Topic
Flavanone
About: Flavanone is a research topic. Over the lifetime, 1965 publications have been published within this topic receiving 54729 citations. The topic is also known as: flavanones.
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TL;DR: From the roots, leaves and pods of Tephrosia pentaphylla three new 6-oxygenated rotenoids (dihydrostemonal, 9-demethyldihydroidstemonal and 6-acetoxydihydristemonal) were isolated and characterized.
45 citations
Patent•
01 Jul 2004TL;DR: In this paper, methods and compositions for modulating the activity of sirtuin deacetylase protein family members are presented, including p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms.
Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
45 citations
TL;DR: Two revised schemes of purification were developed for the recombinant polypeptides of Petunia hybrida, resulting in a homogeneous 3beta-hydroxylase of high specific acitivity at roughly 5% yield and a major breakthrough in mechanistic investigations of this class of labile dioxygenases.
45 citations
TL;DR: In this paper, the same authors showed that immature grapefruits are capable of biosynthesizing flavonoids from simple precursors and suggest that multiple-glycosylation of flavanones may occur by the addition of discrete single sugar units.
45 citations
TL;DR: OsFNS I-1 encodes a flavone synthase I, the first type I FNS I found outside of the Apiaceae family, and it is found that the cofactors oxoglutarate, FeSO(4), ascorbate and catalase are required for this reaction.
Abstract: Flavones are synthesized from flavanones through the action of flavone synthases (FNSs). There are two FNSs, FNS I and II. FNS I is a soluble dioxygenase present in members of the Apiaceae family and FNS II is a membrane bound cytochrome P450 enzyme that has been identified in numerous plant species. In this study, we cloned OsFNS I-1 from rice by RTPCR, expressed it in E. coli, and purified the recombinant protein. By NMR analysis, we found that OsFNS I-1 converted the flavanone (2S)-naringenin into the flavone, apigenin. Moreover, we found that the cofactors oxoglutarate, FeSO(4), ascorbate and catalase are required for this reaction. OsFNS I-1 encodes a flavone synthase I. This is the first type I FNS I found outside of the Apiaceae family.
45 citations