Fluorenone

About: Fluorenone is a research topic. Over the lifetime, 1067 publications have been published within this topic receiving 17162 citations. The topic is also known as: Diphenylene ketone & 9-Oxofluorene.

Fluorenone compounds and preparation method and application thereof

Abstract: The invention discloses fluorenone compounds and a preparation method and application thereof. According to the structural formulas of the fluorenone compounds, R1 is -H, R2 is -OH, a molecular formula is C19H18O6, and one compound is named as gramniphenol D; and R1 is -OH, R2 is -H, a molecular formula is C19H18O6, and the other compound is named as gramniphenol E. According to the preparation method, the fluorenone compounds are prepared from the raw materials including dried branches, leaves or fruits of arundina graminifolia. The preparation method comprises the steps of extract extraction, organic solvent extraction, silica column chromatography and high pressure liquid chromatography separation of the raw materials. The invention further discloses the application of the fluorenone compounds to preparation of anti-AIDS medicines. The gramniphenol D and the gramniphenol E are first detected natural fluorenone replaced by 2-hydroxy-3-methylbut-3-enyloxy. According to cytotoxicity detection on C8166 host cells and inhibition tests on an HIV-1IIIB-induced cytopathic effect (CPE) of the C8166, the two fluorenone compounds have good anti-HIV-1 activity, the EC50 values of the two fluorenone compounds are respectively 1.460.15 mug/mL and 1.580.20 mug/mL, and the therapeutic index (IT) values of the two fluorenone compounds are respectively 137 and 126.6. The fluorenone compounds have novel structures and high activity, and can serve as guiding compounds of the anti-AIDS medicines.

Spirofluorene xanthene phenol compound and preparation method thereof

Abstract: The invention provides a spirofluorene xanthene phenol compound and a preparation method thereof The method comprises the steps of adding 2,7-dihydroxy fluorenone, phenol and a catalyst to a container, wherein the molar ratio of the 2,7-dihydroxy fluorenone to the phenol is 1 to (4-8); the ratio of the catalyst to the 2,7-dihydroxy fluorenone is (01-10) to 1; heating to 120 DEG C to agitate and react for 2 hours; adding concentrated hydrochloric acid, wherein the mass ratio of the concentrated hydrochloric acid to the 2,7-dihydroxy fluorenone is (05-10) to 1; heating to 140 DEG C, keeping warm and reacting for 3 hours, cooling the product to room temperature, adding water to separate out sediment; washing with deionized water, leaching and drying in vacuum to obtain a crude product; recrystalizing the crude product by using ethanol water of which the volume ratio is 1 to 5 at 80 DEG C, and leaching and vacuum-drying the crystal to obtain the refined product The novel heat-resistant epoxy resin, polycarbonate and the like synthetized from the compound disclosed by the invention as the material have the characteristics of good heat stability, high transparency, high refractive index, and solubility and the like, and can be widely applied to the preparation of various materials with excellent performances

Relationship between molecular structure and photoelectric properties in a series of nitro-substituted fluorenone derivatives

Abstract: The photoconductivity of vacuum evaporated thin films of fluorenone and its nitro-substituted derivatives is investigated. A substantial effect of the molecular structure on photoelectric properties is revealed. It is demonstrated that the increase of the number of nitro groups in the molecule leads to photosensitivity enhancement from 0.018 for nitrofluorenone to 0.60 for tetranitrofluorenone. The enhancement is caused by the increased probability of the electron-hole pair formation during the initial stage of photogeneration. The average radius for a thermalized pair decreases from 2.75 to 2.0 nm with the substitution. The activation energy of steady-state photoconductivity for the nitro derivatives coincides with the photogeneration activation energy calculated from the Onsager model.