Foveal

About: Foveal is a research topic. Over the lifetime, 2652 publications have been published within this topic receiving 94120 citations.

Adaptive Optics Retinal Imaging in CNGA3-Associated Achromatopsia: Retinal Characterization, Interocular Symmetry, and Intrafamilial Variability.

Abstract: Purpose To investigate retinal structure in subjects with CNGA3-associated achromatopsia and evaluate disease symmetry and intrafamilial variability. Methods Thirty-eight molecularly confirmed subjects underwent ocular examination, optical coherence tomography (OCT), and nonconfocal split-detection adaptive optics scanning light ophthalmoscopy (AOSLO). OCT scans were used for evaluating foveal hypoplasia, grading foveal ellipsoid zone (EZ) disruption, and measuring outer nuclear layer (ONL) thickness. AOSLO images were used to quantify peak foveal cone density, intercell distance (ICD), and the coefficient of variation (CV) of ICD. Results Mean (±SD) age was 25.9 (±13.1) years. Mean (± SD) best corrected visual acuity (BCVA) was 0.87 (±0.14) logarithm of the minimum angle of resolution. Examination with OCT showed variable disruption or loss of the EZ. Seven subjects were evaluated for disease symmetry, with peak foveal cone density, ICD, CV, ONL thickness, and BCVA not differing significantly between eyes. A cross-sectional evaluation of AOSLO imaging showed a mean (±SD) peak foveal cone density of 19,844 (±13,046) cones/mm2. There was a weak negative association between age and peak foveal cone density (r = -0.397, P = 0.102), as well as between EZ grade and age (P = 0.086). Conclusions The remnant cone mosaics were irregular and variably disrupted, with significantly lower peak foveal cone density than unaffected individuals. Variability was also seen among subjects with identical mutations. Therefore, subjects should be considered on an individual basis for stratification in clinical trials. Interocular symmetry suggests that both eyes have comparable therapeutic potential and the fellow eye can serve as a valid control. Longitudinal studies are needed, to further examine the weak negative association between age and foveal cone structure observed here.

Spatial cuing in a stereoscopic display: Evidence for a “depth-blind” attentional spotlight

Abstract: This experiment explored whether attentional selection observed in a spatial cuing task is based on a representation that includes depth information or not. Targets were presented inside placeholders appearing at the samex,y location on a stereoscopic display, but on different depth planes, or at differentx,y locations on the same depth plane. A peripheral precue produced significant cuing effects in the latter but not in the former condition. In a control experiment, significant cuing effects were found for targets appearing at differentx,y coordinates within the fovea, confirming that the lack of cuing effects in the depth condition was not due to foveal presentation. Together, the results suggest that spatial selection in spatial cuing tasks operates on a representation that does not include depth information.

Anticipatory image capture for stereoscopic remote viewing with foveal priority

Abstract: A client-server arrangement for camera viewing using digital cameras across a computer network. A camera server controls a motorized gimbal which determines the viewing angle of a camera, according to signals from a client computer which is equipped with an eye movement tracking system. Movements of the viewer's eyes result in changes in viewing angle of the remote cameras. The original full-resolution image is divided into a foveal area and a peripheral area. Subsequently, if a change in the peripheral area of a field of view is detected relative to the most recently displayed image, the viewing angle of the cameras is changed to center on the detected change, and an image is captured of this anticipated future field of view. When the viewer eventually changes his or her point of interest to the area of detected change, the pre-captured image is transmitted immediately for viewing.