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French paradox
About: French paradox is a research topic. Over the lifetime, 193 publications have been published within this topic receiving 22567 citations.
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TL;DR: Data from Caerphilly, Wales, show that platelet aggregation, which is related to CHD, is inhibited significantly by alcohol at levels of intake associated with reduced risk of CHD.
3,489 citations
TL;DR: The aim of this review, a summary of the putative biological actions of flavonoids, was to obtain a further understanding of the reported beneficial health effects of these substances.
2,838 citations
TL;DR: In in-vitro studies with phenolic substances in red wine and normal human low-density lipoprotein (LDL) the authors found that red wine inhibits the copper-catalysed oxidation of LDL.
1,650 citations
TL;DR: The role of flavonoids may transcend their presence in food as mentioned in this paper, however, the amount of quercetin that remains biologically available may not be of sufficient concentration, theoretically, to explain the beneficial effects seen with the Mediterranean diet.
1,546 citations
TL;DR: Results from observational studies provide strong evidence that all alcoholic drinks are linked with lower risk, so that much of the benefit is from alcohol rather than other components of each type of drink.
Abstract: Objectives: To review the effect of specific types of alcoholic drink on coronary risk. Design: Systematic review of ecological, case-control, and cohort studies in which specific associations were available for consumption of beer, wine, and spirits and risk of coronary heart disease. Subjects: 12 ecological, three case-control, and 10 separate prospective cohort studies. Main outcome measures: Alcohol consumption and relative risk of morbidity and mortality from coronary heart disease. Results: Most ecological studies suggested that wine was more effective in reducing risk of mortality from heart disease than beer or spirits. Taken together, the three case-control studies did not suggest that one type of drink was more cardioprotective than the others. Of the 10 prospective cohort studies, four found a significant inverse association between risk of heart disease and moderate wine drinking, four found such an association for beer, and four for spirits. Conclusions: Results from observational studies, where alcohol consumption can be linked directly to an individual9s risk of coronary heart disease, provide strong evidence that all alcoholic drinks are linked with lower risk. Thus, a substantial portion of the benefit is from alcohol rather than other components of each type of drink. Key messages Key messages We examined the relation between specific alcoholic drinks and reduction of risk of coronary heart disease by summarising published reports from ecological, case-control, and cohort studies Most ecological studies suggested that wine was more effective in reducing risk of mortality than beer or spirits, whereas the three case-control studies together did not suggest that one type of drink was more cardioprotective than others Of the 10 prospective cohort studies, four found a significant inverse association between risk of heart disease and moderate wine drinking, four found the association for beer, and four found it for spirits. The evidence suggests that all alcoholic drinks are linked with lower risk, so that much of the benefit is from alcohol rather than other components of each type of drink
996 citations