Showing papers on "Friend leukemia published in 1973"
TL;DR: The kinetic parameters of the polycythemic variety of Friend leukemia using DBA2 mice inoculated with the virus were studied and proliferation was mainly observed in the erythroblasts of the spleen.
Abstract: We have studied the kinetic parameters of the polycythemic variety of Friend leukemia using DBA2 mice inoculated with the virus. Proliferation was mainly observed in the erythroblasts of the spleen. The mean duration of the mitotic cycle is 7.6 h and the majority of erythroblasts are in active stages of the cell cycle. The proliferation rate is unaffected even during the hours preceding death. The multiplication of erythroblasts in the spleen results in three different phenomena: 1/3 of the erythroblasts produce short-lived erythrocytes; a very small fraction (1/20) of the proliferation accounts for the slow growth of the spleen and the progressive invasion of the liver and the blood; 2/3 disappear, and this loss is apparently due to massive splenic cellular death.
14 citations
TL;DR: Using the Jerne and Nordin assay for hemolytic antibody plaque forming cells (anti-SRBC PFC), it is found that statolon abrogates the FV-induced immunodepression of the anti- SRBC response.
Abstract: Statolon, an extract of the mold Penicillium stolonijerum containing a double stranded RNA mycophage, can convert a rapidly lethal Friend leukemia viral (FV) infection into a dormant one (1-5). One inoculation of statolon, administered when FV is disseminated throughout the body, induces interferon and FV-cytotoxic antibody thereby suppressing both virus and virus-transformed cells (2, 5). This suppression results in a long lasting clinical remission during which no infective Friend virions can be detected (1, 4). The FV genome is present however, as shown by the spontaneous emergence of FV leukemia late in the life of mice with dormant infections and by the leukemogenicity of spleen cells transferred from mice with dormant infections to normal mice (3).Interferon production leads to suppression of FV replication, but by itself cannot completely suppress the disease; poly I:C and Newcastle disease virus can produce as much interferon as statolon, clear the blood of FV but cannot convert FV leukemia into a...
10 citations