Topic
Friend leukemia
About: Friend leukemia is a research topic. Over the lifetime, 319 publications have been published within this topic receiving 7463 citations.
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TL;DR: The inoculation of viable ascites tumor cells into allogeneic DDD mice induced neither tumor growth nor generalized leukemia, leaving specific resistance against the subsequent challenge of a histocompatible Friend virus‐induced tumor.
Abstract: A transplantable solid tumor and its ascites variant were established from a graft of the enlarged spleen of a C57B1/6 mouse which had been infected with Friend virus shortly after birth. Repeated virus assays on these tumors were mostly negative. The virus content of the tumors was not more than one thousandth of that of the tumors which had been induced by the same virus in A and DDD mice. Under an electron microscope, the chance of observing viral particles in these tumor cells was extremely small. The inoculation of viable ascites tumor cells into allogeneic DDD mice induced neither tumor growth nor generalized leukemia, leaving specific resistance against the subsequent challenge of a histocompatible Friend virus-induced tumor. A single intraperitoneal injection of 2.0 × 107 ascites cells sufficed to retard or suppress the growth of tumor cells used for the test challenge. The use of C57B1/6 mice for the study of Friend leukemia is discussed.
Tumeurs Transplantables, D'origine C57B1/6, Induites par le Virus de Friend et Contenant des Quantites Anormalement Minimes de Virus infectieux Une tumeur transplantable solide et sa variante ascitique ont ete constituees a partir de la greffe de rate hypertrophiee D'UNE souris C57B1/6 qui avait ete infectee par le virus de Friend peu apres la naissance. Les epreuves repetees de recherche du virus pratiquees sur ces tumeurs ont ete negatives pour la plupart. La teneur en virus de ces tumeurs n'etait guere que de 1/1000 de celle des tumeurs induites par le měme virus chez des souris A et DDD. Au microscope electronique, on n'a observe que tres rarement des particules virales dans ces cellules tumorales. L'inoculation de cellules ascitiques viables a des souris DDD allogeneiques n'a provoque ni processus tumoral ni leucemie generalisee, laissant seulement une resistance specifique contre L'inoculation d'epreuve D'UNE tumeur histocompatible induite par le virus de Friend. Une injection intraperitoneale unique de 2.0 × 107 cellules ascitiques suffisait pour retarder ou supprimer le developpement des cellules tumorales utilisees pour L'inoculation d'epreuve. Les auteurs analysent l'utilite des souris C57B1/6 pour l'etude de la leucemie de Friend.
11 citations
TL;DR: The results clearly show that not all mammalian cells undergo dramatic changes in microgravity and that the effects reported on human T lymphocytes represent a unique case.
11 citations
Journal Article•
TL;DR: The results clearly indicate that the spleen plays a crucial role in the mechanism of susceptibility or resistance to the Friend virus and that leukemia development was markedly impaired if the mice were splenectomized.
10 citations
TL;DR: An 11-year-old boy underwent enucleation of his left eye for an intraocular tumor, finding a small, round blue cell tumor arising in the peripheral retina near the ciliary body, which is the first case of primary primitive neuroectodermal tumor of the retina.
Abstract: An 11-year-old boy underwent enucleation of his left eye for an intraocular tumor. Examination showed a small, round blue cell tumor arising in the peripheral retina near the ciliary body. Immunohistochemical stain results were positive for neuron-specific enolase, synaptophysin, cluster of differentiation 99 (CD99), Friend leukemia integration 1, and CD56. Ultrastructural findings included occasional intracytoplasmic dense core granules. Polymerase chain reaction of the tumor showed a Ewing sarcoma/Friend leukemia integration gene fusion product. The tumor was classified as a primitive neuroectodermal tumor/Ewing sarcoma of the retina and should be distinguished from retinoblastoma. To our knowledge, this is the first case of primary primitive neuroectodermal tumor of the retina.
10 citations
TL;DR: The morphological changes occurring after dimethyl sulfoxide stimulation of Friend leukemia cells are compared with those resulting from resuspension in normal medium of cells inhibited by low ionic strength.
Abstract: The effect of medium of low ionic strength on the release of virus from Friend leukemia cells has been studied. The release of infectious Friend leukemia virus is almost completely inhibited in medium of low ionic strength, as measured by a focus-forming assay (XC assay), by endogenous RNA-dependent DNA polymerase activity of released virus particles, and by electron microscope studies of the production of C-type particles. Friend leukemia virus-transformed proerythroblasts undergo extensive morphological changes in low-ionic-strength medium. The cells are viable in this medium, but they can no longer be stimulated with dimethyl sulfoxide to produce hemoglobin and increase virus production. Infectious virus is released between 30 and 120 min of resuspension of inhibited cells in normal medium. The rate of virus release after reversal of the inhibition is much greater than the rate of virus release during normal cell growth. The morphological changes occurring after dimethyl sulfoxide stimulation of Friend leukemia cells are compared with those resulting from resuspension in normal medium of cells inhibited by low ionic strength.
10 citations