Friend leukemia

About: Friend leukemia is a research topic. Over the lifetime, 319 publications have been published within this topic receiving 7463 citations.

Physiopathology of Human and Virus-induced Murine Leukemias

Abstract: The authors describe a coherent model for differentiated leukemias derived from physiopathological studies on Friend leukemia. In Friend leukemia, Friend virus induces permanent differentiation of erythropoietin-responsive cells. This erythropoietic proliferation and maturation is accompanied by a marked cell loss and provokes enlargement of the stem cell compartment. The so-called leukemic cells have a limited proliferation capacity and may not be truly malignant as opposed to blastic cells in acute leukemias. Clinical, hematological, and physiopathological data that are presently available in chronic granulocytic leukemia, polycythemia vera, and the erythroblastic component of erythroleukemia are compatible with the Friend physiopathological model. It is suggested that these differentiated leukemias initiate from an uncontrolled differentiation of a committed cell compartment, which stimulates proliferation of the stem cell compartment. The disease would be due to a proliferation and accumulation of “subnormal” cells characterized by a shorter mean life-span than the normal differentiated cell population. Although limited, the data available suggest that the physiopathology of acute leukemias is clearly distinguishable from that of differentiated leukemias; several immunological and therapeutic applications of this model are outlined.

The Effect of Radiation on Splenomegaly Induced by the Friend Leukemia Virus and Its Modification by Ethyl-N-Bis(2,2-Dimethyl-Ethylamidinophosphoro)-Carbamate (AB-132), Actinomycin D, and AET

Abstract: (1-11) for the assay of the effects of radiation in vivo with or without chemical substances that modify radiation response are based on the evaluation of bone marrow, hair root, thymus, testis, and spleen, on survival time, and on modification of the growth of transplanted tumors. The Friend leukemia virus2 (FLV) (12, 13) induces splenomegaly in appropriate host rodents. The proliferating cells in the spleen of infected mice respond homogeneously to radiation. The rate of enlargement of FLV spleen size depends on the period of time elapsed from the viral inoculation. A tenfold increase of the spleen size occurs in less than 2 weeks after viral inoculation. Laboratory isolation of the virus and its serial passage are easily performed, and the doses of whole-body irradiation required for the inhibition of the proliferating tumor do not affect the viability of the virus. Experiments to determine the value of FLV-induced splenomegaly as a useful tool for the determination of radiation effects are presented in this paper.

Suppression of Friend Virus-induced Leukaemia in Mice by Tuftsin

Abstract: Summary A significant decrease in mortality was observed when 25 µg of the tetrapeptide tuftsin was given to DBA/2J mice 5 days before infection with Friend leukaemia virus (FLV). The same effect was observed when tuftsin was given 5 days before and twice a week for 3 weeks after FLV infection. No effect was observed when the same amount of tuftsin was given 1 day before infection. A 5 µg dose of tuftsin given 5 days before and twice-weekly for 3 weeks had no effect on leukaemia induced by FLV infection. These findings showed that time and dosage were critical to the protective effect of tuftsin against virus-induced leukaemia.

Inhibition of dimethyl sulfoxide-induced Friend erythroleukemia cell differentiation in vitro by lithium chloride.

Abstract: This report describes the ability of ultra-pure lithium chloride (LiCl) to influence the growth kinetics and differentiation of Friend erythroleukemia cells in vitro. LiCl (0.2–50 mEq/l) was effective