Topic
Friend leukemia
About: Friend leukemia is a research topic. Over the lifetime, 319 publications have been published within this topic receiving 7463 citations.
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TL;DR: Results obtained testing tumor growth in lethally irradiated hosts provide further support to the hypothesis that exogenous IFN capable of suppressing the growth of both lines could act via enhancement of the NR function.
6 citations
TL;DR: The data suggest that the "low" in vivo tumorigenicity of in vitro passaged FLC is, at least in part, due to host's NR directed against target structures associated with leukemia cells.
6 citations
TL;DR: These studies, and studies by others, indicate that the immunostimulatory and leukemosuppressive principle in statolon appears to be a dsRNA.
Abstract: Injection of RNA, extracted from statolon by the SDS-phenol method, into FLV-infected mice 24 hours before SRBC immunization restored the immune response to SRBC to normal levels. Leukemosuppression was observed in 50% of the RNA-treated FLV-infected mice. These RNA-treated mice were clinically normal 25 days after infection, whereas all untreated infected mice developed erythroleukemia. Furthermore, all RNA-treated mice with suppressed erythroleukemia produced antibody which was cytotoxic for Friend leukemia cells. Our studies, and studies by others, indicate that the immunostimulatory and leukemosuppressive principle in statolon appears to be a dsRNA.
6 citations
TL;DR: Findings indicate that FLC impairs the afferent limb of the response in contact sensitivity in susceptible BALB/c and resistant C57BL/6 mice after infection with Friend leukemia complex or with RPV.
Abstract: Contact sensitivity to 2-phenyl-4-ethoxymethilene oxazolone, as a probe for cell-mediated immunity, was investigated in susceptible BALB/c and resistant C57BL/6 mice after infection with Friend leukemia complex (FLC) or with Rowson-Parr virus (RPV). In BALB/c mice, FLC depressed contact sensitivity when given before primary sensitization but had no effect on established contact sensitivity nor on the response elicited by a booster application of the sensitizer. These findings, together with the failure to alter reactivity to an aspecific inflammatory stimulus, indicate that FLC impairs the afferent limb of the response. In the same strain of mice RPV infection did not significantly depress contact sensitivity, as judged by the extent of the reaction 24 h after challenge, but slightly inhibited the early antibody-mediated phase of this reaction. In C57BL/6 mice neither viral preparation affected contact sensitivity.
6 citations
TL;DR: The disappearance of a 32 000 D chromatin protein component was observed in cells of the 7 45A “inducible” line harvested as early as 24 h after DMSO treatment, as compared with untreated 745A cells and to cells harvested 6 and 12 h afterDMSO addition to the cultures.
6 citations