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Friend leukemia

About: Friend leukemia is a research topic. Over the lifetime, 319 publications have been published within this topic receiving 7463 citations.


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Journal ArticleDOI
TL;DR: When adriamycin-sensitive and resistant Friend leukemia cells were exposed to cytotoxic concentrations, the pulverization phenomenon was not observed and 75-80% of cells were without breaks, suggesting a different mechanism for cytotoxicity in sensitive and resistant cells.

5 citations

Journal ArticleDOI
TL;DR: Of interest was the observation that bromodeoxyuridine inhibited the biochemical manifestations of erythroid differentiation, but did not prevent the decline in clonogenicity which accompanied differentiation.

5 citations

Journal ArticleDOI
TL;DR: Prostaglandins enhanced the interferon response and therapeutic activity ofinterferon inducers in Friend leukemia virus-infected mice and a similar enhancement in interfron responsiveness but not antiviral activity was observed in mice infected with rapidly acute viruses.
Abstract: Prostaglandins enhanced the interferon response and therapeutic activity of interferon inducers in Friend leukemia virus-infected mice. A similar enhancement in interfron responsiveness but not antiviral activity was observed in mice infected with rapidly acute viruses.

5 citations

Journal ArticleDOI
TL;DR: The phenotypes of the variants inferred from the patterns of resistance or susceptibility to CML were consistent with those presumed from earlier assays using antisera, with the one exception was the variant cell line which was H-2Dd− in assay using antisersa, but was H=Dd+ by CML.
Abstract: H-2 antigen variants, derived from a heterozygous mouse Friend leukemia cell line by selection with anti-H-2 antisera and complement, were tested for susceptibility to cell-mediated cytolysis, using T-lymphocytes directed against individual H-2 antigens. The cytotoxic cells were generated in the BALB and B10 backgrounds by a combination of in vivo and in vitro immunizations. The phenotypes of the variants inferred from the patterns of resistance or susceptibility to CML were consistent with those presumed from earlier assays using antisera. The one exception was the variant cell line which was H-2D(d-) in assays using antisera, but was H-2D(d+) by CML.

5 citations

01 Jan 1984
TL;DR: The lack of any increase in 2-5A synthetase activity with other inducers or other sublines indicates that there is no causal relationship between the enzyme activation and FLC differentiation.
Abstract: I t has been suggested that the interferon (1FN)-induced 2’,5’-oligoadenylate (2-5A) synthetase, which polymerizes ATP into a series of 2‘,5‘-linked oligomers with the general formula pppA(2’pB’A),, plays a general role in cell growth and terminal differentiation. For instance, an increase in 2-5A synthetase activity has been described during dimethyl sulfoxide (MezS0)induced erythroid differentiation of Friend leukemia cells (FLC). 2-5A synthetase has been measured in two Friend leukemia cell sublines by various techniques including a radioimmunoassay of its products which would detect 10”‘ mol of 2-5A cores. Although cells of both sublines fully differentiate (as measured by benzidine staining), only in one subline was there an increase in 2-5A synthetase activity upon treatment with Me2S0. Hexamethylenebisacetamide, another potent agent of differentiation in this system, did not increase 2-5A synthetase activity in either of these two sublines. An IFNresistant FLC variant differentiated normally upon treatment with M e 8 0 or hexamethylenebisacetamide while it was noninducible for 2-5A synthetase activity by exogenous IFN or by the inducers themselves. A similar situation has been observed with regard to the level of phosphorylation of the IFN-induced M, = 67,000 protein band. In addition, treatment of IFNsensitive and resistant FLC sublines with mouse &IFN antiserum did not affect differentiation. Even though we have duplicated previous findings on the increase of 2-5A synthetase activity in MeaSO-induced FLC, the lack of any such increase with other inducers or other sublines indicates that there is no causal relationship between the enzyme activation and FLC differentiation.

5 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20213
20192
20161
20151
20143
20121