Topic
Friend leukemia
About: Friend leukemia is a research topic. Over the lifetime, 319 publications have been published within this topic receiving 7463 citations.
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2 citations
Journal Article•
TL;DR: It is reported here that mice with FLV-dormant infections resist the accumulation of transplantedFLV-transformed erythroleukemia cells (FLC-745) and that FLC-745 cells persist in the spleen for a prolonged period and radiosensitivity of the protective immune response is confirmed.
Abstract: The immunobiology of Friend erythroleukemia virus (FLV) has been the focal point of much research into immunological control of leukemia. We have been studying a murine model in which a rapidly fatal FLV infection of DBA/2 mice is suppressed to a dormant state by treatment with statolon, a double stranded RNA extract of Mycoplasma stoloniferum . We report here that mice with FLV-dormant infections resist the accumulation of transplanted FLV-transformed erythroleukemia cells (FLC-745) and that FLC-745 cells persist in the spleen for a prolonged period. Winn assays revealed that the spleen of FLV-dormant mice contain radiosensitive T-lymphocytes with anti-FLC-745 cell activity. Whole body irradiation of FLV-dormant mice abrogated their resistance to transplanted FLC-745 cells and confirmed the radiosensitivity of the protective immune response.
2 citations
TL;DR: Exposure to 2.0 micrograms/ml cytochalasin B causes loss of viability in Friend erythroleukaemia cells, only observed however in cells undergoing mitosis.
2 citations
TL;DR: Butyrated hydroxyanisole was found to inhibit the appearance of benzidine-positive cells in cultures of Friend leukemia cells treated with the inducers, but did not affect the induction of globin or globin mRNA accumulation.
2 citations
TL;DR: The cells from spleens of D DD mice infected with Friend virus were insensitive to N-demethyl rifampicin in contrast to the cells from DDD mice, suggesting that the change might be due to a virus-induced transformation.
2 citations