Topic
GABAergic
About: GABAergic is a research topic. Over the lifetime, 9595 publications have been published within this topic receiving 473568 citations.
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TL;DR: Pharmacologic experiments indicated that the shower of PSCs was mediated by glutamate, with a small minority caused by the action of GABA.
Abstract: Neuregulins are highly expressed in the CNS, especially in cholinergic neurons. We have examined the effect of neuregulin on nicotinic acetylcholine receptors (nAChRs) in neurons dissociated from the rat hippocampus. Rapid application of acetylcholine (ACh) induced a rapidly rising and decaying inward current in some of the neurons, which was completely blocked by methyllycaconitine, a specific antagonist of the α7 subunit of the nAChR. When the cells were treated with 5 nm neuregulin (NRG1-β1) for 2–4 d, a twofold increase in amplitude of the peak ACh-induced current was observed, and there was a comparable increase in125I-α-bungarotoxin binding. The fast ACh-induced peak current was prominent in large neurons that also contained GABA immunoreactivity. These presumptive GABAergic neurons constituted ∼10% of neurons present in 7- to 9-d-old cultures. In addition to the large inward peak current, ACh also evoked transmitter release from presynaptic nerve terminals. Pharmacologic experiments indicated that the shower of PSCs was mediated by glutamate, with a small minority caused by the action of GABA. Chronic exposure to NRG1-β1 increased the amplitude of ACh-evoked PSCs but not the minimum “quantal” PSC. NRG1-β1 also increased the percentage of neurons that exhibited ACh-evoked PSCs.
156 citations
TL;DR: Optogenetics and whole-cell recordings in brain slices delineate a mechanism in which striatal cholinergic interneurons can co-opt dopamine terminals to drive GABA release and rapidly inhibit striatal output neurons.
156 citations
TL;DR: The migration toward and within the hippocampus, and the maturation of their morphological and neurochemical characteristics are detailed, and potential mechanisms underlying the development of GABAergic interneurons are reviewed.
Abstract: Interneurons are GABAergic neurons responsible for inhibitory activity in the adult hippocampus, thereby controlling the activity of principal excitatory cells through the activation of postsynaptic GABAA receptors. Subgroups of GABAergic neurons innervate specific parts of excitatory neurons. This specificity indicates that particular interneuron subgroups are able to recognize molecules segregated on the membrane of the pyramidal neuron. Once these specific connections are established, a quantitative regulation of their strength must be performed to achieve the proper balance of excitation and inhibition. We will review when and where interneurons are generated. We will then detail their migration toward and within the hippocampus, and the maturation of their morphological and neurochemical characteristics. We will finally review potential mechanisms underlying the development of GABAergic interneurons.
156 citations
TL;DR: It is shown that with maturation, the nicotinic synapses between starburst cells dramatically diminished, whereas the GABAergic synapses remained and changed from excitatory to inhibitory, indicating a coordinated conversion of the starburst network excitability from an early hyperexcitatory to a mature nonepileptic state.
156 citations
TL;DR: The results suggest that most, if not all, of the WGA-HRP-labelled cerebellar terminals in the rostral medial accessory olive (MAO) and the roostral principal olive (PO) are GABAergic.
156 citations