Topic
GABAergic
About: GABAergic is a research topic. Over the lifetime, 9595 publications have been published within this topic receiving 473568 citations.
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TL;DR: It may be concluded that antioxidation and positive modulation of GABAergic neuromodulation of 4-hydroxybenzaldehyde partially contribute to an antiepileptic and anticonvulsive activity of G. elata B1.
146 citations
TL;DR: The role of GABAA receptors in circuit development has been extensively studied in the literature as discussed by the authors, and it has been shown that depolarizing GABA plays a permissive role in promoting both excitatory and inhibitory synaptogenesis in developing neurons.
146 citations
TL;DR: Recordings in urethane anesthetized rats suggest that globus pallidus exerts significant control over the firing rate and pattern of substantia nigra dopaminergic neurons through a disynaptic pathway involving nigral pars reticulata GABAergic neurons and that at least one important way in which local application of bicuculline induces burst firing of dopamine neurons is by disinhibition of this tonic inhibitory input.
146 citations
TL;DR: It is found that, although a large population of inhibitory synapses was homeostatically scaled down after chronic inactivity, decreased endocannabinoid tone specifically strengthened a subset of GABAergic synapses that express cannabinoid receptors.
Abstract: Although most inhibitory synapses are homeostatically scaled down after chronic inactivity, Kim et al. report that chronic inactivity specifically strengthens a subset of hippocampal GABAergic synapses that express cannabinoid receptors. This local tuning effect is mediated by enhanced degradation of anandamide, which reduces basal cannabinoid receptor activation, augmenting GABA release probability.
146 citations
TL;DR: This review focuses on current understanding of the different roles of inhibitory GABAergic non-pyramidal cell subtypes in cortical functions.
145 citations