Topic
GABAergic
About: GABAergic is a research topic. Over the lifetime, 9595 publications have been published within this topic receiving 473568 citations.
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TL;DR: It is shown that ErbB4 is localized at GABAergic terminals of the prefrontal cortex, suggesting the involvement of NRG1, and a role of NRg1, both endogenous and exogenous, in regulation of GABAergic transmission.
286 citations
TL;DR: KCC2, a neuronal-specific isoform of the K(+)-Cl(-) cotransporter, by lowering internal Cl(-), is critical for inhibitory GABA responses in mature central nervous system neurons.
Abstract: Two isoforms of the cation-Cl– cotransporter family are expressed in neurons and modulate neurotransmission. NKCC1, a Na+-K+-2Cl– cotransporter, by raising internal Cl–, is responsible for excitatory GABAergic activity in immature brain and in adult sensory neurons. KCC2, a neuronal-specific isoform of the K+-Cl– cotransporter, by lowering internal Cl–, is critical for inhibitory GABA responses in mature central nervous system neurons.
283 citations
TL;DR: It is shown that the GABAergic component of the LH-VTA pathway supports positive reinforcement and place preference, while the glutamatergic component mediates place avoidance, and photoactivation of these projections modulates other behaviors, such as social interaction and perseverant investigation of a novel object.
281 citations
TL;DR: A direct link between GABA signaling and autistic perceptual symptomatology is presented and a disruption in inhibitory signaling in the autistic brain is suggested, suggesting a translational path between animal and human models of the condition.
281 citations
TL;DR: A robust axo-somato-dendritic gradient is found in which the E GABA values from the AIS to the soma and dendrites become progressively more negative, and it is demonstrated that spatially distinct interneuronal inputs can induce postsynaptic voltage responses with different amplitudes and polarities as governed by the subcellular distributions of plasmalemmal chloride transporters.
Abstract: GABAergic terminals of axo-axonic cells (AACs) are exclusively located on the axon initial segment (AIS) of cortical principal neurons, and they are generally thought to exert a powerful inhibitory action. However, recent work (Szabadics et al., 2006) indicates that this input from AACs can be depolarizing and even excitatory. Here, we used local photolysis of caged GABA to measure reversal potentials (E(GABA)) of GABA(A) receptor-mediated currents and to estimate the local chloride concentration in the AIS compared with other cellular compartments in dentate granule cells and neocortical pyramidal neurons. We found a robust axo-somato-dendritic gradient in which the E(GABA) values from the AIS to the soma and dendrites become progressively more negative. Data from NKCC1(-/-) and bumetanide-exposed neurons indicated that the depolarizing E(GABA) at the AIS is set by chloride uptake mediated by the Na-K-2Cl cotransporter NKCC1. Our findings demonstrate that spatially distinct interneuronal inputs can induce postsynaptic voltage responses with different amplitudes and polarities as governed by the subcellular distributions of plasmalemmal chloride transporters.
280 citations