Topic
Galangin
About: Galangin is a research topic. Over the lifetime, 648 publications have been published within this topic receiving 27112 citations. The topic is also known as: 3,5,7-trihydroxyflavone & 3,5,7-triOH-flavone.
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TL;DR: Several high-quality investigations have examined the relationship between flavonoid structure and antibacterial activity and these are in close agreement, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents.
3,630 citations
TL;DR: The cancer protective effects of flavonoids have been attributed to a wide variety of mechanisms, including modulating enzyme activities resulting in the decreased carcinogenicity of xenobiotics and phase II enzymes, largely responsible for the detoxification of carcinogens.
834 citations
TL;DR: Evidence of anticancer properties of orange juice and indicate that citrus flavonoids are effective inhibitors of human breast cancer cell proliferation in vitro are provided, especially when paired with quercetin, which is widely distributed in other foods.
Abstract: Two citrus flavonoids, hesperetin and naringenin, found in oranges and grapefruit, respectively, and four noncitrus flavonoids, baicalein, galangin, genistein, and quercetin, were tested singly and in one‐to‐one combinations for their effects on proliferation and growth of a human breast carcinoma cell line, MDA‐MB‐435. The concentration at which cell proliferation was inhibited by 50% (IC50), based on incorporation of [3H]thymidine, varied from 5.9 to 140 μg/ml for the single flavonoids, with the most potent being baicalein. IC50 values for the one‐to‐one combinations ranged from 4.7 μg/ml (quercetin + hesperetin, quercetin + naringenin) to 22.5 μxglml (naringenin + hesperetin). All the flavonoids showed low cytotoxicity (>500 μg/ml for 50% cell death). Naringenin is present in grapefruit mainly as its glycosylated form, naringin. These compounds, as well as grapefruit and orange juice concentrates, were tested for their ability to inhibit development of mammary tumors induced by 7,12‐dimethylbe...
501 citations
TL;DR: It is suggested that inhibition of iNOS and COX-2 expression by flavonoids may be one of the mechanisms responsible for their anti-inflammatory effects.
418 citations
TL;DR: Investigation of the antioxidant activity of a propolis extract deprived of caffeic acid phenethyl ester suggests that CAPE plays an important role in the antioxidants activity of propolis.
362 citations