Abstract: Observations of star formation rates (SFRs) in galaxies provide vital clues to the physical nature of the Hubble sequence and are key probes of the evolutionary histories of galaxies. The focus of this review is on the broad patterns in the star formation properties of galaxies along the Hubble sequence and their implications for understanding galaxy evolution and the physical processes that drive the evolution. Star formation in the disks and nuclear regions of galaxies are reviewed separately, then discussed within a common interpretive framework. The diagnostic methods used to measure SFRs are also reviewed, and a self-consistent set of SFR calibrations is presented as an aid to workers in the field. One of the most recognizable features of galaxies along the Hubble sequence is the wide range in young stellar content and star formation activity. This variation in stellar content is part of the basis of the Hubble classification itself (Hubble 1926), and understanding its physical nature and origins is fundamental to understanding galaxy evolution in its broader context. This review deals with the global star formation properties of galaxies, the systematics of those properties along the Hubble sequence, and their implications for galactic evolution. I interpret “Hubble sequence” in this context very loosely, to encompass not only morphological type but other properties such as gas content, mass, bar structure, and dynamical environment, which can strongly influence the largescale star formation rate (SFR).