scispace - formally typeset
Search or ask a question
Topic

Galectin

About: Galectin is a research topic. Over the lifetime, 2076 publications have been published within this topic receiving 103409 citations. The topic is also known as: IPR001079 & Galectin.


Papers
More filters
Journal ArticleDOI
TL;DR: It is proposed that the wide entrance for ligand binding and the shallow binding site of hG9C are favorable for branched oligosaccharides and that Arg221 is responsible for recognizing sialylated oligosACcharides.

41 citations

Journal ArticleDOI
TL;DR: It is shown that endogenous galectin-3 protects intracellular LM by suppressing the autophagic response through a host N-glycan-dependent mechanism and the concept that alterations in cell surface glycosylation by extracellular factors can be deciphered by cytosolic galectins is explored.
Abstract: While glycans are generally displayed on the cell surface or confined within the lumen of organelles, they can become exposed to the cytosolic milieu upon disruption of organelle membrane by various stresses or pathogens. Galectins are a family of β-galactoside-binding animal lectins synthesized and predominantly localized in the cytosol. Recent research indicates that some galectins may act as "danger signal sensors" by detecting unusual exposure of glycans to the cytosol. Galectin-8 was shown to promote antibacterial autophagy by recognizing host glycans on ruptured vacuolar membranes and interacting with the autophagy adaptor protein NDP52. Galectin-3 also accumulates at damaged phagosomes containing bacteria; however, its functional consequence remains obscure. By studying mouse macrophages infected with Listeria monocytogenes (LM), we showed that endogenous galectin-3 protects intracellular LM by suppressing the autophagic response through a host N-glycan-dependent mechanism. Knock out of the galectin-3 gene resulted in enhanced LC3 recruitment to LM and decreased bacterial replication, a phenotype recapitulated when Galectin-8-deficient macrophages were depleted of N-glycans. Moreover, we explored the concept that alterations in cell surface glycosylation by extracellular factors can be deciphered by cytosolic galectins during the process of phagocytosis/endocytosis, followed by rupture of phagosomal/endosomal membrane. Notably, treatment of cells with sialidase, which removes sialic acid from glycans, resulted in increased galectin-3 accumulation and decreased galectin-8 recruitment at damaged phagosomes, and led to a stronger anti-autophagic response. Our findings demonstrate that cytosolic galectins may sense changes in glycosylation at the cell surface and modulate cellular response through differential recognition of glycans on ruptured phagosomal membranes.

41 citations

Journal ArticleDOI
TL;DR: The potential to combine the two library-based approaches for structural optimization of lead peptides, including phage-display and combinatorial pentapeptide library, is documents.

40 citations

Journal ArticleDOI
TL;DR: It is demonstrated that the expression of galectin-1 gene from the flounder Paralichthys olivaceus was decreased in the initial 8 h after challenge with poly I:C, then increased markedly from 24 h onwards, and the recombinant galectIn-1 was able to neutralize the lymphocystis disease virus (LCDV), inhibiting the formation of cytopathic effects.

40 citations

Journal ArticleDOI
TL;DR: This review discusses pre-BCR analogies and differences between the two species leading to pre-B cell differentiation and proliferation, and the mechanisms triggering pre- BCR activation are reviewed, taking into account the recent report of heparan sulfates and galectin 1 as stromal cell-derived pre- BCCR ligands.

40 citations


Network Information
Related Topics (5)
Cell culture
133.3K papers, 5.3M citations
85% related
Signal transduction
122.6K papers, 8.2M citations
84% related
Immune system
182.8K papers, 7.9M citations
83% related
Receptor
159.3K papers, 8.2M citations
82% related
Cellular differentiation
90.9K papers, 6M citations
82% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023182
2022176
2021107
2020120
201995
2018119