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Galectin

About: Galectin is a research topic. Over the lifetime, 2076 publications have been published within this topic receiving 103409 citations. The topic is also known as: IPR001079 & Galectin.


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Journal ArticleDOI
TL;DR: Its higher frequency in patients with SLE suggests a pathogenic role, and the first description of autoantibodies against galectin-8 is described, is described.
Abstract: The family of lectins known as galectins (galectins1-14) are involved in the regulation of the immune system and in oncogenesis During a searchfor antigens recognized by antibodies produced by a patient with systemic lupus erythematosus(SLE) we found reactivity against galectin-8, for which autoantibodies have not been previouslydescribed

13 citations

Book ChapterDOI
TL;DR: The function of endogenous galectin-3 as determined by comparison of phagocytosis by macrophages from galectIn-3 knockout mice and wild-type mice is emphasized.
Abstract: Galectins, a family of β-galactoside-binding proteins, are expressed in many different phagocytic leukocytes (granulocytes, monocytes, and macrophages). A number of family members have been shown to play an important role in ingestion of particles (phagocytosis), thus contributing to clearance of damaged cells and host defense against pathogens. Here we describe procedures for analysis of the roles of galectins in phagocytosis by using galectin-3 as an example. We emphasize the function of endogenous galectin-3 as determined by comparison of phagocytosis by macrophages from galectin-3 knockout mice and wild-type mice. We focus on the role of galectin-3 in phagocytosis of pathogens and Fcγ receptor-mediated phagocytosis of opsonized cells and particles.

13 citations

01 Jan 2012
TL;DR: In this paper, the 1 H, 13 C, and 15 N chemical shift assignments for human galectin-7 dimer were determined by using heteronuclear, triple resonance NMR spectroscopy.
Abstract: Galectins are multifunctional proteins with carbohydrate/protein-binding properties and distinct expression profiles. Homodimeric galectin-7 (p53-induced gene 1) is a potent pro-apoptotic effector with clinical relevance. Here, we report 1 H, 13 C, and 15 N chemical shift assignments for human galectin-7 dimer as determined by using heteronuclear, triple resonance NMR spectroscopy.

13 citations

Journal ArticleDOI
TL;DR: Two modalities are suggested that released Gal-3 could directly facilitate the metastatic process through the interaction of metastatic cancer cells with vascular endothelium and the adhesion of melanoma cells to elastin-rich tissues such as skin and lung tissue.
Abstract: Dear Sir, Galectin-3 (Gal-3) is a member of the family of β-galactoside-binding mammalian lectins known as galectins.1 To date, 14 galectins have been described and various members of the galectin family have been shown to modulate cell growth, cell adhesion and cell apoptosis.2 Galectin-3 has been reported to be expressed in the nucleus, in the cytoplasm and on the cell surface, and can be secreted without a signal peptide into the extracellular compartment by an unusual secretory mechanism.3 Several in vitro and in vivo studies have demonstrated a possible role for this protein in tumour invasion, metastatic cascade and inflammation.2,4,5 High serum Gal-3 concentrations have been reported in patients with advanced colorectal carcinoma, breast cancer and melanoma.6 We recently demonstrated Gal-3 expression in melanoma.7 We suggest two modalities, which are not mutually exclusive, to explain the possible roles of a high serum level of Gal-3 in patients with advanced melanoma (Fig. 1). The first modality is that released Gal-3 could directly facilitate the metastatic process through the interaction of metastatic cancer cells with vascular endothelium and the adhesion of melanoma cells to elastin-rich tissues such as skin and lung tissue.1,2,5,8 Gal-3 is known to participate in the linking of cancer cells to capillary endothelium and to enhance adhesion of cancer cells to extracellular matrix proteins such as laminin, elastin and collagen IV.

13 citations

Journal ArticleDOI
TL;DR: The results underline special features at each site of specimen origin as well as the importance of analyzing galectins as a network and of defining the expression status of the individual patient prior to reaching clinically relevant conclusions.
Abstract: Background/Aim: Expression profiling was performed to delineate and characterize the impact of malignancy by comparing tissues from three sites of head and neck cancer of each patient, also determining interindividual variability. Materials and Methods: Genome-wide analysis was carried out covering the expression of 25,832 genes with quantification for each site of seven patients with tonsillar or oropharyngeal squamous cell carcinoma. Immunohistochemical analysis was performed for adhesion/growth-regulatory galectins, three pro-inflammatory chemo- and cytokines and keratins. Results: Up- and down-regulation was found for 281 (tumor vs. normal) and 276 genes ( transition zone vs. normal), respectively. The profile of the transition zone had its own features, with similarity to the tumor. Galectins were affected in a network manner, with differential regulation and interindividual variability between patients, also true for keratins and the chemo- and cytokines. Conclusion: These results underline special features at each site of specimen origin as well as the importance of analyzing galectins as a network and of defining the expression status of the individual patient prior to reaching clinically relevant conclusions.

13 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023182
2022176
2021107
2020120
201995
2018119