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Galectin

About: Galectin is a research topic. Over the lifetime, 2076 publications have been published within this topic receiving 103409 citations. The topic is also known as: IPR001079 & Galectin.


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Journal ArticleDOI
11 Sep 2018-PLOS ONE
TL;DR: A protective effect of Gal-Nab1 and Gal-nab2 on the apoptotic cell death induced by gal-9 in primary T cells is reported, and cross-species recognition will be an advantage for their assessment in pre-clinical tumor models.
Abstract: Extra-cellular galectin-9 (gal-9) is an immuno-modulatory protein with predominant immunosuppressive effects Inappropriate production of gal-9 has been reported in several human malignancies and viral diseases like nasopharyngeal, pancreatic and renal carcinomas, metastatic melanomas and chronic active viral hepatitis Therefore therapeutic antibodies neutralizing extra-cellular gal-9 are expected to contribute to immune restoration in these pathological conditions Two novel monoclonal antibodies targeting gal-9 -Gal-Nab 1 and 2-have been produced and characterized in this study We report a protective effect of Gal-Nab1 and Gal-Nab2 on the apoptotic cell death induced by gal-9 in primary T cells In addition, they inhibit late phenotypic changes observed in peripheral T cells that survive gal-9-induced apoptosis Gal-Nab1 and Gal-Nab2 bind nearly identical, overlapping linear epitopes contained in the 213-224 amino-acid segments of gal-9 Nevertheless, they have some distinct functional characteristics suggesting that their three-dimensional epitopes are distinct These differences are best demonstrated when gal-9 is applied on Jurkat cells where Gal-Nab1 is less efficient than Gal-Nab2 in the prevention of apoptotic cell death In addition, Gal-Nab1 stimulates non-lethal phosphatidylserine translocation at the plasma membrane and calcium mobilization triggered by gal-9 in these cells Both Gal-Nab1 and 2 cross-react with murine gal-9 They bind its natural as well as its recombinant form This cross-species recognition will be an advantage for their assessment in pre-clinical tumor models

9 citations

Journal ArticleDOI
TL;DR: Gene therapy using IFN-β-gal-9 fusion proteins is expected to be safe and effective for the treatment of MS, and in vivo experiments showing beneficial therapeutic effects without cytopenia are indicated.

9 citations

Journal ArticleDOI
TL;DR: It is confirmed that LEC-1 forms a complex with N-acetyllactosamine-containing glycoproteins, and a crosslinked product was formed with the Q38C mutant, strongly suggesting the low-affinity interaction of Nh with the glycoprotein could be detected with this system.

9 citations

Journal ArticleDOI
TL;DR: Galectins are a family of proteins that bind β-galactosides and play key roles in a variety of cellular processes including host defence as discussed by the authors, but less so in gastrointestinal nematodes.
Abstract: Galectins are a family of proteins that bind β-galactosides and play key roles in a variety of cellular processes including host defence. They have been well studied in hosts but less so in gastrointestinal nematodes. Both host and parasite galectins are present in the gastrointestinal tract following infection. Parasite galectins can both bind antibody, especially highly glycosylated IgE and be bound by antibody. Parasite galectins may act as molecular sponges that soak up antibody. Host galectins promote mast cell degranulation while parasite galectins inhibit degranulation. Host and parasite galectins can also bind mucins and influence mucus viscosity. As the protective response against gastrointestinal nematode infection is partly dependent on IgE mediated mast cell degranulation and mucus, the interactions between host and parasite galectins play key roles in determining the outcome of infection.

9 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023182
2022176
2021107
2020120
201995
2018119