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Ganciclovir

About: Ganciclovir is a research topic. Over the lifetime, 4730 publications have been published within this topic receiving 161911 citations. The topic is also known as: Vitrasert & GA2.


Papers
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Journal ArticleDOI
12 Jun 1992-Science
TL;DR: Direct in situ introduction of exogenous genes into proliferating tumors could provide an effective therapeutic approach for treatment of localized tumors and to spare nondividing neural tissue.
Abstract: Direct in situ introduction of exogenous genes into proliferating tumors could provide an effective therapeutic approach for treatment of localized tumors. Rats with a cerebral glioma were given an intratumoral stereotaxic injection of murine fibroblasts that were producing a retroviral vector in which the herpes simplex thymidine kinase (HS-tk) gene had been inserted. After 5 days during which the HS-tk retroviral vectors that were produced in situ transduced the neighboring proliferating glioma cells, the rats were treated with the anti-herpes drug ganciclovir. Gliomas in the ganciclovir- and vector-treated rats regressed completely both macroscopically and microscopically. This technique exploits what was previously considered to be a disadvantage of retroviral vectors--that is, their inability to transfer genes into nondividing cells. Instead, this feature of retroviruses is used to target gene delivery to dividing tumor cells and to spare nondividing neural tissue.

1,678 citations

Journal ArticleDOI
TL;DR: A double mutant of the herpes simplex virus type 1 (termed G207) with favourable properties for treating human malignant brain tumours: replication–competence in glioblastoma cells, attenuated neurovirulence, temperature sensitivity, ganciclovir hypersensitivity, and the presence of an easily detectable histochemical marker.
Abstract: We have created a double mutant of the herpes simplex virus (HSV) type 1 (termed G207) with favourable properties for treating human malignant brain tumours: replication–competence in glioblastoma cells (and other dividing cells), attenuated neurovirulence, temperature sensitivity, ganciclovir hypersensitivity, and the presence of an easily detectable histochemical marker. G207 has deletions at both γ34.5 (RL1) loci and a lacZ gene insertion inactivating the ICP6 gene (UL39). G207 kills human glioma cells in monolayer cultures. In nude mice harbouring subcutaneous or intracerebral U–87MG gliomas, intraneoplastic inoculation with G207 causes decreased tumour growth and/or prolonged survival. G207 is avirulent upon intracerebral inoculation of mice and HSV–sensitive non–human primates. These results suggest that G207 should be considered for clinical evaluation in the treatment of glioblastomas.

790 citations

Journal ArticleDOI
TL;DR: Once‐daily oral valganciclovir was as clinically effective and well‐tolerated as oral ganciclovIR tid for CMV prevention in high‐risk SOT recipients and the safety profile was similar for both drugs.

779 citations

Journal ArticleDOI
TL;DR: In this paper, the authors evaluated the efficacy and safety of ganciclovir therapy in neonates with congenital cytomegalovirus (CMV) disease and found that 20% of the infants had improved hearing or maintained normal hearing between baseline and 6 months versus 10% of 17 control patients.

778 citations

Journal ArticleDOI
01 Jun 2002-Blood
TL;DR: Anti-CMV cellular therapy was successful in 5 of 7 patients, whereas in 2 of7 patients, who received an intensified immune suppression at the time of or after T-cell therapy, only transient reductions in virus load were obtained.

724 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202398
2022190
2021105
202089
201995
2018119