Topic
Garcinia cambogia
About: Garcinia cambogia is a research topic. Over the lifetime, 312 publications have been published within this topic receiving 3946 citations.
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TL;DR: G cambogia failed to produce significant weight loss and fat mass loss beyond that observed with placebo and was not influenced by treatment group.
Abstract: Context.—Hydroxycitric acid, the active ingredient in the herbal compound Garcinia cambogia, competitively inhibits the extramitochondrial
enzyme adenosine triphosphate–citrate (pro-3S)-lyase. As a citrate cleavage
enzyme that may play an essential role in de novo lipogenesis inhibition, G cambogia is claimed to lower body weight and reduce fat
mass in humans.Objective.—To evaluate the efficacy of G cambogia for
body weight and fat mass loss in overweight human subjects.Design.—Twelve-week randomized, double-blind, placebo-controlled trial.Setting.—Outpatient weight control research unit.Participants.—Overweight men and women subjects (mean body mass index [weight in kilograms
divided by the square of height in meters], approximately 32 kg/m2).Intervention.—Subjects were randomized to receive either active herbal compound (1500
mg of hydroxycitric acid per day) or placebo, and both groups were prescribed
a high-fiber, low-energy diet. The treatment period was 12 weeks. Body weight
was evaluated every other week and fat mass was measured at weeks 0 and 12.Main Outcome Measures.—Body weight change and fat mass change.Results.—A total of 135 subjects were randomized to either active hydroxycitric
acid (n=66) or placebo (n=69); 42 (64%) in the active hydroxycitric acid group
and 42 (61%) in the placebo group completed 12 weeks of treatment (P=.74). Patients in both groups lost a significant amount of weight
during the 12-week treatment period (P<.001);
however, between-group weight loss differences were not statistically significant
(mean [SD], 3.2 [3.3] kg vs 4.1 [3.9] kg; P=.14).
There were no significant differences in estimated percentage of body fat
mass loss between treatment groups, and the fraction of subject weight loss
as fat was not influenced by treatment group.Conclusions.—Garcinia cambogia failed to produce significant
weight loss and fat mass loss beyond that observed with placebo.
347 citations
TL;DR: The principal acid in the highly acidic fruits of Garcinia cambogia has been identified as (-)-======hydroxycitric acid as mentioned in this paper, which has not been encountered in nature before.
155 citations
TL;DR: It is shown that the extracts as well as (-)-hydroxycitric acid (HCA), a main organic acid component of the fruit rind, exhibited anti-obesity activity including reduced food intake and body fat gain by regulating the serotonin levels related to satiety, increased fat oxidation and decreased de novo lipogenesis.
149 citations
TL;DR: The highest dose of HCA-containing Garcinia cambogia extract showed significant suppression of epididymal fat accumulation in developing male Zucker obese rats, compared with the other groups, however, the diets containing 102 mmol HCA/kg diet and higher caused potent testicular atrophy and toxicity, whereas diets containing 51 mmol HCS diet (389 mg H CA/kg BW/d) or less did not.
113 citations
TL;DR: Hypolipidemic activity of these flavonoids may be due to a lower rate of lipogenesis and higher rate of degradation of cholesterol in rats fed normal and cholesterol-containing diets.
91 citations