Topic
Garcinia pedunculata
About: Garcinia pedunculata is a research topic. Over the lifetime, 41 publications have been published within this topic receiving 501 citations.
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TL;DR: The effect of hexane and chloroform extracts from the fruit rinds of Garcinia cowa and Garcinia pedunculata on the growth and aflatoxin production in Aspergillus flavus was studied using peanut powder as a model food system.
98 citations
TL;DR: This study is the first report on the in vitro antibacterial activity of extracts from the fruit rinds of G. cowa and G. pedunculata and it was found that the hexane and chloroform extracts exhibited marked inhibitory effect against all the test organisms and were more effective than that of the other extracts.
Abstract: The crude hexane and chloroform extracts from the fruit rinds of Garcinia cowa and Garcinia pedunculata were studied for their antibacterial activity against some foodborne pathogens and spoilage bacteria such as Bacillus cereus , Bacillus coagulans , Bacillus subtilis , Staphylococcus aureus and Escherichia coli . The minimum inhibitory concentrations (MICs) of the extracts determined by the agar dilution method were ranging from 15 to 500 μg/ml and 300 to 1250 μg/ml for G. cowa and G. pedunculata , respectively. However, the hexane and chloroform extracts from the fruit rinds of G. cowa exhibited marked inhibitory effect against all the test organisms and were more effective than that of G. pedunculata extracts. The antibacterial activity of all the extracts was more pronounced against the tested Gram-positive bacteria than the tested Gram-negative bacterium. Furthermore, this study is the first report on the in vitro antibacterial activity of extracts from the fruit rinds of G. cowa and G. pedunculata .
82 citations
TL;DR: Pedunculol, a polyisoprenylated benzophenone derivative, together with garcinol and cambogin has been isolated from the pericarp of Garcinia pedunculata as mentioned in this paper.
42 citations
TL;DR: In this paper, the authors used β-carotene-linoleate model system and α, α-diphenyl-β-picrylhadrazyl (DPPH) method at various concentrations.
Abstract: Diet rich in fruits and vegetables has been associated with preventing mutagenesis and cancer and other health benefits. In the present study, hexane and chloroform extracts from the fruit rinds of Garcinia pedunculata were tested for their antioxidative and antimutagenic activities. Both the hexane and chloroform extracts showed antioxidant activity studied through β-carotene–linoleate model system and α, α-diphenyl-β-picrylhadrazyl (DPPH) method at various concentrations. At 500 ppm concentration, in case of β-carotene–linoleate model system, the hexane and chloroform extracts of G. pedunculata showed 60 and 67% antioxidant activity respectively, whereas the free radical scavenging activity was 45% and 65%, respectively with DPPH method. The antimutagenicity of the hexane and chloroform extracts against the mutagenicity of direct acting mutagen sodium azide was determined by the Ames test. Both the extracts showed strong antimutagenicity at or above 1250 μg/plate in the tester strains of Salmonella typhimurium (TA100 and TA1535). However, the hexane extract showed higher antimutagenic potential than the chloroform extract. Thus, this preliminary study documents for the first time the antioxidant and antimutagenic properties of the extracts from the fruit rinds of G. pedunculata . Industrial relevance This study describes the antioxidative and antimutagenic activities of the extracts from the fruit rinds of Garcinia pedunculata . Oxidative stress has been linked to various diseases while food industry long has been concerned with issues such as rancidity and oxidative spoilage of foodstuffs. Natural antioxidants from plant extracts have attracted the attention of consumers due to probable mutagenic and carcinogenic properties of the synthetic antioxidants in food and there is an increasing demand for natural compounds in place of synthetic ones. Hence these extracts can be utilized as nutraceuticals and as food biopreservatives. Moreover, these fruit rinds of Garcinia pedunculata are rich in (−)-hydroxycitric acid (HCA), which is a proven natural antiobese agent. After extractions of these bioactive fractions, the residuals can be used for HCA extraction.
41 citations
TL;DR: The findings suggest that GP fruit is effective against hyperglycemia and could be used in the treatment of diabetes and its complications and other oxidative stress-mediated pathological conditions.
Abstract: The antihyperglycemic, antidiabetic, and antioxidant potentials of the methanolic extract of Garcinia pedunculata (GP) fruit in rats were investigated. The acute antihyperglycemic effect of different doses of GP was studied in normal male Wistar rats. Diabetes was induced by streptozotocin (STZ) injection in another cohort of male Wistar rats and they showed significantly higher blood glucose and glycated hemoglobin (HbA1c) levels, altered lipid profiles, and lower insulin levels compared to nondiabetic control animals. There were increased lipid peroxidation and reduced levels of cellular antioxidant enzymes in different tissues of diabetic rats. However, oral administration of GP extracts, especially the highest dose (1000 mg/kg), significantly ameliorated hyperglycemia (42%); elevated insulin levels (165%); decreased HbA1c (29.4%); restored lipid levels (reduction in TG by 25%, TC by 15%, and LDL-C by 75% and increase in HDL-C by 4%), liver and renal function markers, and lipid peroxidation (reduction by 52% in the liver, 39% in the kidney, 44% in the heart, and 46% in the pancreas); and stimulated tissue antioxidant enzymes to near normalcy. Overall, the findings suggest that GP fruit is effective against hyperglycemia and could be used in the treatment of diabetes and its complications and other oxidative stress-mediated pathological conditions.
40 citations