Glucal

TL;DR: A total synthesis of the 12-membered ring natural macrolide, sporiolide B, was achieved from D-glucal in 17 steps with 4.8% overall yield.

TL;DR: Sharma et al. as discussed by the authors showed that diethylaminosuliiz trifluoride is a useful reagent for the replacement of the carbonyl oxygen in sugars and glycosides protected with the isopropylidene groups.

TL;DR: In this paper, the enantiodivergent synthesis of (+)-and (−)-isolaurepan was achieved from a common chiral template easily available from tri-O-acetyl-d -glucal, using as key step a diastereoselective thermal Claisen rearrangement, combined with a ring expansion reaction using trimethylsilyldiazomethane.