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Topic

Glucoside

About: Glucoside is a(n) research topic. Over the lifetime, 3183 publication(s) have been published within this topic receiving 56075 citation(s). The topic is also known as: glucosides.


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Journal ArticleDOI
TL;DR: It is suggested that quercetin glucoside is actively absorbed from the small intestine, whereas quercettin rutinoside is absorbed fromThe colon after deglycosylation, suggesting that Absorption of other food components might also be enhanced by attachment of a glucose group.
Abstract: Flavonoids are antioxidants present in plant foods. They occur mainly as glycosides, i.e. linked with various sugars. It is uncertain to what extent dietary flavonoid glycosides are absorbed from the gut. We investigated how the nature of the sugar group affected absorption of one major flavonoid, quercetin. Quercetin linked with glucose, i.e. quercetin glucoside and quercetin linked with rutinose, i.e. quercetin rutinoside, both occur widely in foods. When we fed these compounds to nine volunteers, the peak concentration of quercetin (Cmax) in plasma was 20 times higher and was reached (Tmax) more than ten times faster after intake of the glucoside (Cmax = 3.5 ± 0.6 μM (mean ± SE); Tmax < 0.5 h) than after the rutinoside (Cmax = 0.18 ± 0.04 μM; Tmax = 6.0 ± 1.2 h). The bioavailability of the rutinoside was only 20% of that of the glucoside. We suggest that quercetin glucoside is actively absorbed from the small intestine, whereas quercetin rutinoside is absorbed from the colon after deglycosylation. Abso...

478 citations

Patent
15 May 2003
Abstract: An SGLT2 inhibiting compound is provided having the formula[Chemical structure] A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or in combination with another antidiabetic agent or other therapeutic agent.

327 citations

Journal ArticleDOI
TL;DR: The apparent bioavailability of genistein and daidzein is not different when consumed as either aglycone or glucoside by American women, probably because of the metabolic action of intestinal bacteria during the long intestinal transit time of glucosides.
Abstract: Background: Test results on the bioavailability of isoflavones in the aglycone or glucoside form in Eastern and Western human subjects are contradictory. Objective: The objective was to investigate the bioavailability of the soy isoflavones daidzein and genistein in American women with typical American dietary habits after ingestion of the aglycone or glucoside form of isoflavones. Design: Fifteen American women aged 46 ± 6 y participated in a randomized, double-blind study. Blood samples were collected 0, 1, 2, 4, 8, 12, 24, and 48 h after consumption of aglycone or glucoside tablets with breakfast. The plasma curves for daidzein, genistein, and equol were constructed and the postprandial maximum concentration (C max ), time to the maximum concentration (t max ), and area under the curve (AUC) were determined. Results: Isoflavone concentrations peaked early (1-2 h) in plasma and peaked again at 4-8 h. Mean C max , t max , and AUC values for genistein were not significantly different after ingestion of aglycone or glucoside. However, C max and AUC values, but not t max , were significantly higher for daidzein after aglycone ingestion, which was partly due to its higher content in the aglycone tablets. Equol appeared after 4 h and remained elevated after 48 h. Despite a higher content of daidzein in the aglycone tablets, the AUC for equol was significantly higher after ingestion of the glucoside tablets, probably because of the metabolic action of intestinal bacteria during the long intestinal transit time of glucoside. Conclusion: The apparent bioavailability of genistein and daidzein is not different when consumed as either aglycone or glucoside by American women.

296 citations

Journal ArticleDOI
Abstract: The phenolic compounds present in 29 samples of olive fruits were analysed by reversed-phase HPLC/DAD and/or HPLC-DAD/ESI-MS/MS. All samples were collected during the normal picking period for olive oil production, in north and central Portugal, and were obtained from 18 different olive cultivars. Two different extraction methods were necessary for the complete quantification of phenolic compounds, a methanolic extraction and an extraction which included a solid-phase extraction (SPE) cleaning step. The analyses showed that all samples presented a similar profile, which included at least six identified phenolic compounds: hydroxytyrosol, luteolin 7- O -glucoside, oleuropein, rutin, apigenin 7- O -glucoside and luteolin. Several samples also contained 5- O -caffeoylquinic acid, verbascoside, quercetin 3- O -rhamnoside, cyanidin 3- O -glucoside and cyanidin 3- O -rutinoside. In all samples, hydroxytyrosol and oleuropein were the major compounds identified while, in general, rutin and luteolin 7- O -glucoside were the two main flavonoids. The influences of maturation index, nature of the cultivar and geographical origin are discussed.

289 citations

Journal ArticleDOI
TL;DR: The mechanism of absorption of quercetin-4'-glucoside involves both an interaction with SGLT1 and luminal hydrolysis by LPH, whereas quercETin-3-glucOSide appears to be absorbed only following hydrolytic action of LPH.
Abstract: Two hypotheses on absorption mechanisms of flavonoid glucosides across the small intestine have been proposed: active uptake of the quercetin glucoside by the sodium-dependent glucose transporter (SGLT1) with subsequent deglycosylation within the enterocyte by cytosolic beta-glucosidase, or luminal hydrolysis of the glucoside by lactase phlorizin hydrolase (LPH) and absorption by passive diffusion of the released aglycone. To test the above hypotheses we employed phlorizin (as an inhibitor of SGLT1) and N-(n-butyl)-deoxygalactonojirimycin (as an inhibitor of the lactase domain of LPH) in a rat everted-jejunal sac model. Quercetin-4'-glucoside mucosal hydrolysis was 10 times greater than quercetin-3-glucoside hydrolysis in the absence of inhibitors (449 and 47 nmol g(-1) tissue, respectively), despite the similar amounts (13+/-4 and 9+/-1 nmol g(-1), respectively) being transferred to the serosal compartment during the 15 min incubation. Apical hydrolysis of both quercetin glucosides was significantly reduced in the presence of NB-DGJ (80%), and transfer of quercetin (measured as quercetin metabolites) to the serosal solution was also significantly reduced (40-50%). In the presence of phlorizin, transfer of metabolites to the serosal solution was only reduced in the case of quercetin-4'-glucoside. Evidently the mechanism of absorption of quercetin-4'-glucoside involves both an interaction with SGLT1 and luminal hydrolysis by LPH, whereas quercetin-3-glucoside appears to be absorbed only following hydrolysis by LPH.

289 citations

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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20222
202141
202066
201976
201873
201798