scispace - formally typeset
Search or ask a question

Showing papers on "Glucoside published in 2006"


Journal ArticleDOI
TL;DR: The results of this study showed that anthocyanins from blueberries could be transported through the Caco-2 cell monolayers although the transport/absorption efficiency was relatively low compared to other aglycone polyphenols.
Abstract: Recent studies have shown that dietary polyphenols may contribute to the prevention of cardiovascular disease and cancer. Anthocyanins from different plant sources including blueberries have been shown to possess potential anticancer activities. One of the key factors needed to correctly relate the in vitro study results to human disease outcomes is information about bioavailability. The objectives of the current study were to evaluate the absorption of blueberry anthocyanin extracts using Caco-2 human intestinal cell monolayers and investigate the effects of different aglycones, sugar moieties, and chemical structure on bioavailability of different types of anthocyanins. The results of this study showed that anthocyanins from blueberries could be transported through the Caco-2 cell monolayers although the transport/absorption efficiency was relatively low compared to other aglycone polyphenols. The transport efficiency of anthocyanins averaged approximately 3-4% [less than 1% in delphinidin glucoside (Dp-glc)]. No significant difference in transport/absorption efficiency was observed among three blueberry cultivars. The observed trends among different anthocyanins generally agreed well with some published in vivo results. Dp-glc showed the lowest transport/absorption efficiency, and malvidin glucoside (Mv-glc) showed the highest transport/absorption efficiency. Our result indicates that more free hydroxyl groups and less OCH(3) groups can decrease the bioavailability of anthocyanins. In addition, cyanindin glucoside (Cy-glc) showed significantly higher transport efficiency than cyanidin galactoside (Cy-gal), and peonidin glucoside (Pn-glc) showed significantly higher transport efficiency than peonidin galactoside (Pn-gal), indicating that glucose-based anthocyanins have higher bioavailability than galactose-based anthocyanins.

173 citations


Journal ArticleDOI
TL;DR: The results showed that cytotoxic activity of a second group of hederagenin glucoside saponins was a result of both the sugar part and the structure of genin (carboxylic acid or methyl ester).

131 citations


Journal ArticleDOI
TL;DR: Using RT-PCR, the enzymological and molecular data support the possibility of a monolignol glucoside/beta-glucosidase system in Arabidopsis lignification.

113 citations


Journal ArticleDOI
TL;DR: The N-terminal sequence of the purified enzyme showed a significant homology with the family 1 β-glucosidases of Trichoderma reesei and Humicola isolens even though these two enzymes are much smaller in size.

108 citations


Journal ArticleDOI
TL;DR: In this article, a reversed-phase HPLC analysis of methanol extract of the seeds of Centaurea montana afforded a flavanone, montanoside (4), six epoxylignans, berchemol (7), berchemolate 4′- O -β-d-glucoside (5), pinoresinol (10), pinoreinol 4- O −β- d -glucose (8), pinOREINOL 4,4′-di-O -β -d -glocoside

95 citations


Journal ArticleDOI
TL;DR: The kinetic study indicated that acacetin 7- O-(3- O-acetyl- beta- D-glucopyranoside) displayed competitive- type inhibition like that of allopurinol, while displayed a mixed-type inhibition.
Abstract: From the MeOH extract of the flowers of Chrysanthemum sinense, a new flavone glucoside, acacetin 7- O-(3- O-acetyl- beta- D-glucopyranoside), has been isolated together with 27 known compounds including flavonoids, caffeoylquinic acid derivatives, phenolics, and a monoterpenoid glucoside. Their structures were elucidated on the basis of spectroscopic data. Compounds and displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compounds and showed more potent inhibitory activity, with IC50 values ranging from 0.13 to 2.31 microM, than that of a positive control allopurinol (IC50=2.50 microM). The kinetic study indicated that and displayed competitive-type inhibition like that of allopurinol, while displayed a mixed-type inhibition.

81 citations


Journal ArticleDOI
TL;DR: L lithospermic acid B (and its stereoisomers), p-menth-3-ene-1,2-diol 1-O-beta-glucopyranoside, 12-hydroxyjasmonic acid, and 12-HydroxyjasMonic acid 12-O -beta- glucopyrside were isolated for the first time from Origanum species.
Abstract: From the polar extracts of Origanum vulgare L. ssp. hirtum 19 compounds have been isolated. The structures and relative stereochemistry have been elucidated by spectroscopic analysis and determined as apigenin, luteolin, chrysoeriol, diosmetin, quercetin, eriodictyol, cosmoside, vicenin-2, caffeic acid, p-menth-3-ene-1,2-diol 1-O-beta-glucopyranoside, thymoquinol 2-O-beta-glucopyranoside, thymoquinol 5-O-beta-glucopyranoside, thymoquinol 2,5-O-beta-diglucopyranoside, 12-hydroxyjasmonic acid, 12-hydroxyjasmonic acid 12-O-beta-glucopyranoside, lithospermic acid B, rosmarinic acid, 10-epi-lithospermic acid, and epi-lithospermic acid B. The three latter products display unusual stereochemistry of the 3,4-hydroxyphenyllactic acid unit(s), which to the authors' best knowledge has never been reported before in similar compounds. Moreover, lithospermic acid B (and its stereoisomers), p-menth-3-ene-1,2-diol 1-O-beta-glucopyranoside, 12-hydroxyjasmonic acid, and 12-hydroxyjasmonic acid 12-O-beta-glucopyranoside were isolated for the first time from Origanum species.

63 citations


Journal ArticleDOI
TL;DR: Limonin glucoside was deemed not to be an antioxidant on the basis of the three unequivocal assays, indicating that they do not possess any inherent AOC and should not be considered antioxidants.
Abstract: The antioxidant capacity (AOC) of three representative citrus limonoids, limonin, nomilin, and limonin glucoside, was examined by the oxygen radical absorbance capacity (ORAC), Trolox equivalent antioxidant capacity (TEAC), beta-carotene-linoleic acid bleaching, and 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assays. Pure compounds and proper negative (cinnamic acid) and positive (2,6-di-tert-butyl-4-methylphenol (BHT) and ascorbic acid) controls were used to remove any ambiguity in interpreting results. In all cases, limonin and nomilin gave results equivalent to those of cinnamic acid, indicating that they do not possess any inherent AOC and should not be considered antioxidants. Similar results were observed for limonin glucoside, with the exception of an anomalous result obtained from the beta-carotene-linoleic acid bleaching assay. Limonin glucoside was deemed not to be an antioxidant on the basis of the three unequivocal assays.

53 citations


Journal ArticleDOI
TL;DR: From Sarcolobus globosus, two rotenoids (villosinol and 6-oxo-6a,12a-dehydrodeguelin), one isoflavone (genistin) and four phenolic glycosides (vanillic acid 4-O-beta-d-glucoside, glucosyringic acid, tachioside and isotachiosides) were identified for the first time from this species.

40 citations


Journal ArticleDOI
TL;DR: One new stillbene glucoside (6), along with five known compounds (1–5), were isolated from the roots of Polygonum multiflorum Thumb, and their chemical structures established based on physicochemical and spectroscopic data.
Abstract: One new stillbene glucoside (6), along with five known compounds (1–5), were isolated from the roots ofPolygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound3 showed DNA topoisomerase I and II inhibitory activities.

33 citations


Journal ArticleDOI
TL;DR: The first triterpenoid saponins from a plant in the genus Caryocaraceae were described in this article, where they were found to be bidesmosides with one glucose unit linked to C-28 of the aglycon.
Abstract: Twenty-one new triterpenoid saponins, named caryocarosides (1-21), glycosides of 2beta-hydroxyoleanolic acid, hederagenin, bayogenin, and gypsogenic acid, have been isolated from the fruits of Caryocar glabrum along with nine known triterpenoid saponins (22-30) that are described for the first time from a plant in the Caryocaraceae. Their structures were established by 1D and 2D NMR techniques ((13)C, COSY, TOCSY, HSQC, HMBC, and ROESY experiments), ESIMS, and acid hydrolysis. The isolated compounds could be classified into two series: glucosides (1-8, 22, 27, and 30) derived from the 3-O-monoglucoside and glucuronides (9-21, 23-26, 28, and 29) derived from the 3-O-monoglucuronide. In 22 of the saponins (1-8, 12-22, and 24-26), a galactose moiety was linked to C-3 of a glucuronic acid or a glucose moiety. The galactose was substituted in position 3 by a second galactose unit (6, 7, 20, and 21) or by a xylose unit (8). Seven saponins (4, 5, 16-19, and 26) were found to be bidesmosides with one glucose unit linked to C-28 of the aglycon. The hemolytic activity of the major saponins (2, 3, 5, 12-15, 17, 24, and 28) was measured on sheep erythrocytes in order to establish structure-activity relationships based on the type of sugar attached to the aglycon and on the structure of this aglycon.

Journal ArticleDOI
TL;DR: The major anthocyanins of boysenberry fruit, a cross between Rubus loganbaccus and Rubus baileyanus Britt.
Abstract: The major anthocyanins of boysenberry fruit, a cross between Rubus loganbaccus and Rubus baileyanus Britt., were isolated by preparative high-performance liquid chromatography (HPLC). The structures of cyanidin-3-[2-(glucosyl)glucoside] (1) and cyanidin-3-[2-(glucosyl)-6-(rhamnosyl)glucoside] (2) were determined by NMR in 1% DCOOD/D2O. An unusually high chemical shift (δ 2.5) is reported for H-5‘ ‘‘ of cyanidin-3-[2-(glucosyl)glucoside]. Keywords: Anthocyanins; boysenberry; NMR spectroscopy; cyanidin-3-[2-(glucosyl)glucoside]; cyanidin-3-[2-(glucosyl)-6-(rhamnosyl)glucoside]; cyanidin-3-O-glucoside, cyanidin-3-[6-(rhamnosyl)glucoside]

DOI
01 Sep 2006
TL;DR: In this article, the structures of all eight compounds were elucidated by IR, MS, and NMR spectral data, and they showed cytotoxicity against KB cell line with IC50 values of 30.05 and 17.91 μg/mL, respectively.
Abstract: Five flavonoids cirsimaritin (1), cirsimarin (2), cirsiliol 4'-glucoside (3), sorbifolin (4), and pedalitin (5) along with betulin, vanillic acid, and indole-3-carboxaldehyde were isolated from the EtOAc extracts of Ruellia tuberosa. The structures of all eight compounds were elucidated by IR, MS, and NMR spectral data. Compounds 1 and 3 showed cytotoxicity against KB cell line with the IC50 values of 30.05 and 17.91 μg/mL, respectively, while compound 2 was cytotoxic against HepG2 cell line with an IC50 value of 38.83 μg/mL.

Journal Article
TL;DR: In this paper, the structures of the isolated compounds were elucidated by means of spectroscopic (UV, IR, 1D- and 2D-NMR, and FAB-MS) methods using the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH), spectroscopically.
Abstract: An iridoid glucoside, lamiide (1); 4 phenylethanoid glycosides, acteoside (2), b-OH acteoside (3), leucosceptoside A (4) and samioside (5); a caffeic acid ester, chlorogenic acid (6); 2 flavone glucosides, luteolin-7-O-glucopyranoside (7) and chrysoeriol-7-O-glucopyranoside (8); and a flavanone aglycone, naringenin (9), were isolated from the aerial parts of Phlomis syriaca. The structures of the isolated compounds were elucidated by means of spectroscopic (UV, IR, 1D- and 2D-NMR, and FAB-MS) methods. Free radical scavenging activity of the isolated compounds was determined using the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH), spectroscopically.

Journal ArticleDOI
TL;DR: Wang et al. as discussed by the authors used spectroscopic methods to identify quercetin-7-O-β-D-[6”-O-(trans-feruloyl)]-glucopyranoside (compound 1), 8-C-p-HydroxybenzylquercetIN(compound 2), isorhamnetin-3-O-,β-,D-glocopyranoide(3), 5-hydroxy-3′,4′,7-trimethoxyflavon
Abstract: Eight compounds were isolated from the ethyl acetate- and n-butanol-soluble fractions of the ethanolic extract of the whole plant of Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae). On the basis of spectroscopic methods, the structures of these compounds were elucidated as quercetin-7-O-β-D-[6”-O-(trans-feruloyl)]-glucopyranoside (compound 1), 8-C-p-Hydroxybenzylquercetin (compound 2), isorhamnetin-7-O-β-D-glucopyranoside (compound 3), isorhamnetin-3-O-β-D-glucopyranoside (compound 4), kaempferol-3-O-β-D-glucopyranoside (compound 5), kaempferol-7-O-β-D-glucopyranoside (compound 6), 5-hydroxy-3′,4′,7-trimethoxyflavonol-3-O-β-D-rutinoside (compound 7), and isorhamnetin-3-O-β-D-rutinoside (compound 8). Of the compounds isolated, compound 1 was a new flavonoid glucoside and exhibited strong scavenging activity against the 1,1-diphenyl-2-picrylhydrazyl free radical, whereas the ethanolic extract showed weak activity. Compounds 2–8 were obtained from this family for the first time. (Managing editor: Wei Wang)

Journal ArticleDOI
TL;DR: Two new iridoid glucosides, namely, 2′‐O‐[(2E,4E)‐5‐phenylpenta‐2,4‐dienoyl]mussaenosidic acid (1) and 2′-O‐(4‐methoxycinnamoyl)mussAenosidIC acid (2), were isolated from the aerial parts of the mangrove plant Avicennia marina.
Abstract: Two new iridoid glucosides, namely, 2'-O-[(2E,4E)-5-phenylpenta-2,4-dienoyl]mussaenosidic acid (1; mussacnosidic acid= [1S-(1 alpha,4a alpha,7 alpha,7a alpha)]-1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-7-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid) and 2'-O-(4-methoxycinnamoyl)mussaenosidic acid (2), were isolated from the aerial parts of the mangrove plant Avicennia marina. Beside that, one known iridoid glucoside, 2'-O-coumaroylmussaenosidic acid (3) and four known flavones (flavone = 2-phenyl-4H-1-benzopyran-4-one) including 4',5-dihydroxy-3',7-dimethoxyflavone (4), 4',5-dihydroxy3',5',7-trimethoxyflavone (5), 4',5,7-trihydroxyflavone (6), and 3',4',5-trihydroxy-7-methoxyflavone (7) were also isolated and identified. The structures of these compounds were elucidated by NMR spectroscopy and by low- and high-resolution mass spectrometry. The chemotaxonomic significance of these findings was discussed. In addition, each isolated compound was evaluated for the ability of alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radical-scavenging activity.

Journal ArticleDOI
TL;DR: Two new iridoid glucosides were isolated from the aerial parts of Verbena brasiliensis VELL and their chemical structures were determined on the basis of spectroscopic data.
Abstract: Two new iridoid glucosides, verbenabraside A (1) and verbenabraside B (2), were isolated from the aerial parts of Verbena brasiliensis VELL., along with six known iridoid glucosides, gelsemiol 3-O-beta-D-glucoside (3), verbraside (4), 9-hydroxysemperoside (5), griselinoside (6), aralidioside (7), and 6alpha-hydroxyforsythide dimethyl ester (8), three known phenylethanoid glycosides, 2-phenylethyl O-beta-D-xylopyranosyl-(1-->2)-beta-D-glucopyranoside (9), acteoside (10), and leucosceptoside A (11), two known lignan glucosides, dihydroxymethyl-bis(3,5-dimethoxy-4-hydroxyphenyl) tetrahydrofuran-9 (or 9')-O-beta-glucopyranoside (12) and (+)-lyoniresinol 3alpha-O-beta-D-glucopyranoside (13), a known methyl salicylate glucoside, methyl 2-O-beta-D-glucopyranosylbenzoate (14), and two known sterols, beta-sitosterol 3-O-beta-D-glucopyranoside (15) and beta-sitosterol (16). Their chemical structures were determined on the basis of spectroscopic data. Compound 1 exhibited stronger scavenging effect on the stable free radical 1,1-diphenyl-2-picrylhydrazyl than that of alpha-tocopherol.

Journal ArticleDOI
TL;DR: A soluble glucoside 3-dehydrogenase from Stenotrophomonas maltrophilia CCTCC M 204024, recently isolated from wheat soil in the authors' laboratory, was purified to 37.4-fold with a yield of 24.7% and exhibited extremely broad substrate specificity.
Abstract: A soluble glucoside 3-dehydrogenase (G3DH) from Stenotrophomonas maltrophilia CCTCC M 204024, recently isolated from wheat soil in our laboratory, was purified to 37.4-fold with a yield of 24.7% and was estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis with a molecular mass of 66 kDa. 2,6-Dichlorophenolindophenol (DCPIP) and ferricyanide were able to act as artificial electron acceptors for the enzyme. The optimal pH of G3DH was in the range of 6.0-7.0 in the presence of DCPIP. The enzyme was stable in the pH range of 4.4-10.6 and was sensitive to heat. G3DH exhibited extremely broad substrate specificity by converting many sugars to their corresponding 3-ketoglucosides. They produced a characteristic spectrum by alkaline treatment with a peak at 340 nm. The apparent Km values for validoxylamine A and D: -glucose were 8.3 and 1.1 mM, respectively. Cu2+, Ag2+, and Hg2Cl2 inhibited the activity of G3DH.

Journal ArticleDOI
TL;DR: From the aerial parts of Citharexylum spinosum L., one new iridoid glucoside, the 7-β-O-acetate of lamiide, along with four known iridoids glucosides, lamiidoside (2), lamiidside (3), duranterectoside C (4), 8-epiloganin (5) and one known lignan glucosid (+)-lyonirenisol

Journal ArticleDOI
TL;DR: The results show that the biotransformation of flavonoids is very complex and may result not only in a loss but also in a gain of biological activity depending on the individual structural features.
Abstract: Flavonoids are known as biologically active compounds. Although this has been shown by several in vivo studies, it is still elusive whether their metabolites exert similar activities. Herein we investigated the biotransformation of four different flavonoids, 3',4'-dihydroxyflavone, apigenin, luteolin and luteolin 7-O-glucoside, by cultured rat hepatocytes using a combination of enzymatic deconjugation, HPLC separation and high-resolution mass spectrometry. These flavonoids were chosen because they are active components of many plants, e. g., artichokes. All flavonoids showed rather complex metabolite patterns dominated by phase II metabolites, mainly sulfates, methyl sulfates and methyl glucuronides, but also of combined glucuronide and sulfate conjugates. Phase I metabolism by hydroxylation was rendered likely only for apigenin to form luteolin. When culture media containing the flavonoids and their metabolites were assayed for antioxidative capacity by the DPPH assay, only compounds with hydroxy groups in position 3' and 4' of the B ring were active. Thus, during metabolism of (inactive) apigenin a strong increase in the antioxidative effect was observed while that of the other three flavonoids decreased with time. Determination of EGF receptor tyrosine kinase activity likewise revealed strong inhibition in the presence of a catechol group at ring B. However, in this case the situation was much more complex resulting in a significant increase of the inhibitory activity of 3',4'-dihydroxyflavone and apigenin, but not of luteolin and luteolin 7-O-glucoside during 22 h of incubation. These results show that the biotransformation of flavonoids is very complex and may result not only in a loss but also in a gain of biological activity depending on the individual structural features.

Journal ArticleDOI
TL;DR: In this article, 10 different almond β-glucosidases, from eight commercial sources, were compared for their capacity to produce octyl glucoside by direct condensation from glucose and octanol, with and without added dimethyl formamide (DMF) in the octanol media.
Abstract: Ten different almond β-glucosidases, from eight commercial sources, were compared for their capacity to produce octyl glucoside by direct condensation from glucose and octanol, with and without added dimethyl formamide (DMF) in the octanol media. All the preparations tested catalyzed the synthesis of octyl glucoside, at rates ranging from 0.002 to 0.012 μmol/h, per added unit of enzyme, one unit being defined as the amount of enzyme catalyzing the hydrolysis of 1 μmol of p -nitrophenyl-β- d -glucopyranoside ( p -NPG) per minute at 50 °C at pH 4.8. However, none of the preparations showed strong activation by DMF, contrary to what has been previously observed. Some preparations were slightly activated (two-fold maximum) by 10% DMF. It appears that the enzymes with the lowest specific activity for the hydrolysis of p -NPG were activated more strongly by DMF than the most active preparations.

Journal ArticleDOI
TL;DR: Extraction of roots and stems of Cleistanthus gracilis furnished common triterpenes, plant sterols and the unusual glucoside (+) gracicleistanthoside, the glucosides of 2-beta-hydroxy-8-azabicyclo-(5,2,0)-4beta,9beta-epoxynona-5,7-diene.

Journal ArticleDOI
TL;DR: In this paper, the synthesis and reactivity of C-glucosyl vinyl sulfones in two steps from benzylated gluconolactone and benzothiazolylsulfones derivatives is reported.
Abstract: The synthesis and the reactivity of C-glucosyl vinyl sulfones in two steps from benzylated gluconolactone and benzothiazolylsulfones derivatives is reported.

Journal ArticleDOI
TL;DR: A new minor sesquiterpene lactone glucoside, ixerin ZA (1), together with 16 known compounds, were isolated from the whole plants of Ixeris sonchifolia (Bge) Hance and exhibited an inhibitory effect on K562 cells.

Journal ArticleDOI
TL;DR: In this paper, a new plumieride type iridoid glucoside, morinipticoside was isolated from the leaves and branches of Morinda elliptica together with six known compounds.
Abstract: A new plumieride type iridoid glucoside, morinipticoside, was isolated from the leaves and branches of Morinda elliptica together with six known compounds; asperuloside, asperulosidic acid, yopaaoside A, yopaaoside B, benzyl α-l-arabinopyranosyl (1→6)-β-d-glucopyranoside and phenyethyl α-l-arabinopyranosyl (1→6)-β-d-glucopyranoside. The structure determinations were based on physical data and spectroscopic evidence.

Journal Article
TL;DR: A new acylated iridoid glucoside, namely, 2'-O-(5-phenyl-2E, 4E-pentadienoyl)mussaenosidic acid, was isolated from the aerial parts of the mangrove plant Avicennia marina as discussed by the authors.

Journal ArticleDOI
TL;DR: A new glucoside, selaginoside, together with two known compounds, hinokiflavone and 2,3-dihydroamentoflavone, were isolated from the whole plants of Selaginella sinensis and their structures were elucidated by means of spectroscopic methods.

Journal ArticleDOI
TL;DR: A new ionone glucoside, (-)(4R*, 5R*)-5-(β-D-glucopyranosyloxymethyl)-4-hydroxy-3,5-dimethyl-4-((E)-3-oxobut-1-enyl)cyclohex-2-enone (biebersteiniside) (1), in addition to four known compounds, 6-e...
Abstract: A new ionone glucoside, (-)(4R*, 5R*)-5-(β-D-glucopyranosyloxymethyl)-4-hydroxy-3,5-dimethyl-4-((E)-3-oxobut-1-enyl)cyclohex-2-enone (biebersteiniside) (1), in addition to four known compounds, 6-e...

Journal Article
TL;DR: A new aliphatic glucoside, isolated from the hexane extract of aerial parts of Clerodendrum inerme, has been characterized as pentadecanoic acid-p-D-glucoside on the basis of spectral data analyses and chemical studies as mentioned in this paper.
Abstract: A new aliphatic glucoside, isolated from the hexane extract of aerial parts of Clerodendrum inerme, has been characterized as pentadecanoic acid-p-D-glucoside, on the basis of spectral data analyses and chemical studies. Stigmasterol glucoside was also isolated from the same extract for the first time from this plant species. The butanol extract afforded acacetin and apigenin.

Journal Article
TL;DR: A new acylated secoiridoidal glucoside, named gentiorigenoside A, was isolated from the root of Gentiana rigescens (Gentianaceae), together with eight known compounds and their structures were elucidated on the basis of detailed spectroscopic analysis.
Abstract: A new acylated secoiridoidal glucoside,named gentiorigenoside A (1),was isolated from the root of Gentiana rigescens (Gentianaceae),together with eight known compounds,gentiopicroside (2),6′-O-β-D-glucopyranosyl gentiopicroside (3),loganic acid (4),6′-O-β-D-glucopyranosyl loganic acid (5),sweroside (6),2′-(o,m-dihydoxybenzyl)-sweroside (7),swertiamarin (8) and secologanoside (9). heir structures were elucidated on the basis of detailed spectroscopic analysis.Iridoidal glucosides 3,5 and 9 were isolated for the first time from the title plant.