Showing papers on "Glucoside published in 2021"
TL;DR: The free, esterified and bound forms of 37 phenolic compounds (including hydroxybenzoic acid, hydroxycinnamic acids, flavanols, flavonols and flavones) from walnut kernel (Juglans regia L.) were investigated in this paper.
43 citations
TL;DR: The in vitro and in silico study revealed that the QG, QDG, isoquercetin, and spiraeoside from ROSW exhibited potent α-glucosidase, tyrosinase and xanthine oxidase enzyme inhibitory activity and showed potent anticancer effect on HeLa cancer lines.
41 citations
TL;DR: The results indicate that the anthocyanin profiles as well as the high phenolic and flavonoid contents are important factors determining the antioxidant effects of black adzuki bean.
32 citations
TL;DR: The soluble and insoluble-bound phenolic fractions of hull, whole, and dehulled black and green lentil extracts were identified and quantified using electrospray ionization (ESI)-MS/MS as discussed by the authors.
16 citations
TL;DR: The results showed that anthocyanins colour stabilization can be promoted by pectic polysaccharide structures such as those extracted by cold carbonate, showing the preferential stabilization of the flavylium cation.
12 citations
TL;DR: In this paper, the effects of three types of phenolic copigments (gallic acid, (-)-epicatechin, and quercetin-3-O-glucoside) on the stability and color properties of five common 3O-monoglucosidic anthocyanins in model wine solutions were investigated.
11 citations
TL;DR: Four of the isolated compounds isolated from Lycium schweinfurthii showed a potent inhibitory activity and thus constitute a therapeutic approach to decrease postprandial hyperglycemia in diabetic patients.
9 citations
TL;DR: In this article, the anti-oomycete activity of A. unedo leaves extract against Phytophthora cinnamomi was reported. And the results showed that a methanol extract containing an arbutin equivalent concentration of 2.5 mg mL−1 was lethal for this pathogen.
Abstract: This is the first report of the anti-oomycete activity of A. unedo leaves extract against Phytophthora cinnamomi. The extract was characterized by HPLC–MS and different chemotypes identified.
Arbutus unedo L. is a small perennial Ericaceae tree well adapted to the environmental conditions of its Mediterranean distribution area. It produces a wide range of secondary metabolites with bioactive properties and applications for food, cosmetic and pharmaceutical industries. Due to the antifungal activity of some secondary metabolites they can play a key role in plant defense. In particular, arbutin and hydroquinone, two phenolic compounds typical of the Ericaceae species, might be especially important in plant defense against pathogens. Thus, in this work we (i) established a phenolic fingerprint of wild strawberry tree leaves, (ii) evaluated the effect of genotype and seasonal variation on phenolic metabolite composition, (iii) quantified arbutin and hydroquinone, and (iv) tested the antifungal effect of arbutin, hydroquinone and a methanol extract of A. unedo leaves against common strawberry tree pathogens. A total of 54 compounds were assigned by HPLC–PDA–ESI/MSn, namely, gallic acid derivatives, hydrolysable and condensed tannins, flavonoids, arbutin, hydroquinone and their derivatives, and significant differences on relative abundance of the phenolic compounds between individuals were verified. Hydroquinone and its glucoside arbutin were quantified and its antifungal and anti-oomycete effect against A. unedo pathogens evaluated. Arbutin concentrations ranged from 0.69 ± 0.05 to 22.97 ± 0.76 mg g−1 fresh weight of leaves. Hydroquinone was only detected in a few samples and its concentration ranged from 0.069 ± 0.004 to 0.604 ± 0.024 mg g−1 fresh weight. Both arbutin and hydroquinone induced a reduction in growth of Glomerella cingulata and both compounds were highly effective against Phytophthora cinnamomi, with a reduction in growth close to 80% at the higher arbutin concentration tested. Microplate tests showed that a methanol extract of A. unedo leaves displayed an anti-oomycete activity with MIC (minimum inhibitory concentration) against P. cinnamomi at an arbutin equivalent concentration of 0.625 mg mL−1, and was more active against P. cinnamomi than the arbutin standard (MIC = 12 mg mL−1), which suggests that a synergic effect occurs in the presence of other metabolites existing in the extract. Moreover, extract containing an arbutin equivalent concentration of 2.5 mg mL−1 was lethal for this pathogen. Arbutin, their derivatives and/or other secondary metabolites play an important role in A. unedo defense mechanisms against biotic stress, opening the way to biotechnological applications, namely, to use A. unedo leaf extracts as a natural phytosanitary agent. A genotype with the ability to produce high amounts of arbutin was also identified. The implications of these results on agroforestry management are discussed, as well as its relevance on plant phenotyping and selection for future breeding assays.
8 citations
TL;DR: In this article, the synthesis of syringin (1), along with its natural analogues 2-12, from a common starting material, syringaldehyde (13), with an overall yields of 11.8-61.3%.
Abstract: Syringin (1), a natural bioactive glucoside isolated from the root of Acanthopanax senticosus (Rupr. Maxim.) Harms, possesses significant anti-inflammatory activity. In this study, we have accomplished the total syntheses of syringin (1), along with its natural analogues 2-12, from a common starting material, syringaldehyde (13), in 4-8 steps with an overall yields of 11.8-61.3%. The anti-inflammatory activities of these compounds were determined against NO production in the LPS-stimulated RAW264.7 cells. Among them, compounds 1-5, 7, and 9 exhibited different levels of anti-inflammatory activity.
7 citations
TL;DR: In this paper, a full factorial design was performed to optimize the maceration process and the recovery of the extract, and the iC₅Xyl concentration, temperature, stirring, and extraction time.
Abstract: Rosemary (Rosmarinus officinalis L.) is a Mediterranean herb known for its high antioxidant power that has been widely attributed to carnosic acid (CA). Passive extractions of CA have been performed in water by using five commercially available short-chain alkyl polyglycosides (APG) with alkyl chain lengths ranging from 4 to 10 carbon atoms and polar heads composed of pentoses and/or glucoses. APGs are nontoxic amphiphiles with high biodegradability. Their solubilizing capacity for CA has been determined, highlighting heptyl glucoside (C₇Glu) as the most efficient one, followed by 2-ethylhexyl glucoside (C₆,–₂Glu) and isoamyl xyloside (iC₅Xyl). However, iC₅Xyl exhibited the highest selectivity toward CA solubilization as compared to ursolic acid (UA), a potential coextracted compound of rosemary leaves. In addition, it was found to be the most efficient amphiphile to extract CA from both ground and whole rosemary leaves. To optimize the maceration process and the recovery of the extract, a full factorial design 2⁴ was performed investigating iC₅Xyl concentration, temperature, stirring, and extraction time. A high concentration of hydrotrope was found to be the most important condition to optimize the maceration step, while the temperature particularly increases the yield, but in detriment of the CA content in the final dried extract.
7 citations
TL;DR: Plant extract at dose of 500 mg/kg body weight of reduced the blood glucose level to considerable extent and also improved lipid profile of diabetic mice after 28 days trial, revealed the medicinal potential of Cycas circinalis leaves to treat diabetes mellitus and provided the nutraceutical leads for functional food development.
Abstract: Background Cycas circinalis leaves are used to treat diabetes mellitus in local medicinal systems without any scientifically proved information on their medicinal potential and phytochemicals. In this study, the total phenolic contents, total flavonoid contents, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and inhibitory effects on α-glucosidase and α-amylase were determined for optimized hydroethanolic leaf extracts. Secondary metabolites were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS). In vivo studies on diabetic albino mice were also carried out to evaluate the impact of the most active extract on their blood glucose levels. Results The 60% ethanolic extract showed the highest extract yield (209.70 ± 0.20 g kg-1 ) and total phenolic (154.24 ± 3.28 mg gallic acid equivalent) and flavonoid (78.52 ± 1.65 mg rutin equivalent per gram dried extract) contents and exhibited the maximum DPPH scavenging activity (IC50 = 59.68 ± 2.82 μg mL-1 ). The IC50 values for inhibition of α-glucosidase (58.42 ± 2.22 μg mL-1 ) and α-amylase (74.11 ± 1.70 μg mL-1 ) were also significant for the 60% ethanolic extract. The untargeted UHPLC-QTOF-MS/MS-based metabolite profiling confirmed the presence of iridoid glucoside, gibberellin A4, O-β-d-glucosyl-4-hydroxy-cinnamate, 3-methoxy-2-phyenyl-4H-furo[2,3-h]chromen-4-one, kaempferol, withaferin A, amentoflavone, quercitin-3-O-(6″-malonyl glucoside), ellagic acid, and gallic acid. Plant extract at a dose of 500 mg kg-1 body weight reduced the blood glucose level by a considerable extent and also improved the lipid profile of diabetic mice after a 28-day trial. Conclusion The findings revealed the medicinal potential of C. circinalis leaves to treat diabetes mellitus and provided the nutraceutical leads for functional food development. © 2020 Society of Chemical Industry.
TL;DR: The results demonstrate that newly characterized quercetin glycoside from fresh leaves of fenugreek possesses potential anti-inflammatory and antioxidant activities.
Abstract: Trigonella foenum-graecum L. (fenugreek) leaves are nutritionally rich green leafy vegetables consumed in South-East Asian and Middle-Eastern countries. Scientific data suggests properties includin...
TL;DR: In this paper, the inhibitory properties towards α-glucosidase in vitro and elevation of post-prandial glycemia in mice by the saponin constituent from Eleocharis dulcis peel were evaluated for the first time.
Abstract: The inhibitory properties towards α-glucosidase in vitro and elevation of postprandial glycemia in mice by the saponin constituent from Eleocharis dulcis peel were evaluated for the first time. Three saponins were isolated by silica gel and HPLC, identified as stigmasterol glucoside, campesterol glucoside and daucosterol by NMR spectroscopy. Daucosterol presented the highest content and showed the strongest α-glucosidase inhibitory activity with competitive inhibition. Static fluorescence quenching of α-glucosidase was caused by the formation of the daucosterol–α-glucosidase complex, which was mainly derived from hydrogen bonds and van der Waals forces. Daucosterol formed 7 hydrogen bonds with 4 residues of the active site and produced hydrophobic interactions with 3 residues located at the exterior part of the binding pocket. The maltose-loading test results showed that daucosterol inhibited elevation of postprandial glycemia in ddY mice. This suggests that daucosterol from Eleocharis dulcis peel can potentially be used as a food supplement for anti-hyperglycemia.
TL;DR: In this paper, a new compound, 3-O-(4-O-methyl-β-D-glucopyranosyl) xanthone (1) was isolated from the culture of Conoideocrella luteorostrata NBRC106950 The structure of 1 was mainly determined by 1H, 13C, 2D-NMR and HREIMS spectral analyses
TL;DR: In this article, the authors used SBA-15 and tungstophosphoric acid (TPA) catalysts for glucoside glycolysis with n-butanol.
TL;DR: In this paper, the identification of novel menthol glycosyltransferases from the tea plant opens new perspectives for the biotechnological production of menthyl glucoside.
Abstract: Menthol is a cyclic monoterpene alcohol of the essential oils of plants of the genus Mentha, which is in demand by various industries due to its diverse sensorial and physiological properties. However, its poor water solubility and its toxic effect limit possible applications. Glycosylation offers a solution as the binding of a sugar residue to small molecules increases their water solubility and stability, renders aroma components odorless and modifies bioactivity. In order to identify plant enzymes that catalyze this reaction, a glycosyltransferase library containing 57 uridine diphosphate sugar-dependent enzymes (UGTs) was screened with (±)-menthol. The identity of the products was confirmed by mass spectrometry and nuclear magnetic resonance spectroscopy. Five enzymes were able to form (±)-menthyl-β-d-glucopyranoside in whole-cell biotransformations: UGT93Y1, UGT93Y2, UGT85K11, UGT72B27 and UGT73B24. In vitro enzyme activity assays revealed highest catalytic activity for UGT93Y1 (7.6 nkat/mg) from Camellia sinensis towards menthol and its isomeric forms. Although UGT93Y2 shares 70% sequence identity with UGT93Y1, it was less efficient. Of the five enzymes, UGT93Y1 stood out because of its high in vivo and in vitro biotransformation rate. The identification of novel menthol glycosyltransferases from the tea plant opens new perspectives for the biotechnological production of menthyl glucoside.
13 Jul 2021
TL;DR: In this paper, two undescribed benzofuran e-caprolactams featuring a unique 7/6/5 fused tricyclic framework with p-glucosyl-O-phenyl unit were isolated from the root of Tibetan medicinal plant Oxybaphus himalaicus.
TL;DR: A double benefit is a kind of strategy for separate efficiency by selecting the appropriate method, the small molecule in plant extracts can be effectively extracted CCK-8 method was employed to bioassay-guide Magnetic separation was adopted as extraction probe to capture and enrich potent cytotoxicity constituent Borate functionalized magnetic solid (BFMS) was performed for two purposes to wrap hydrophobic and to leave hydrophilic component from the ethyl acetate extract of O malacophyllus, fortunately, (R)-lotastralin, 1-O-alpha-D-gl
TL;DR: Even at the lowest tested concentration, 11.4 μg/mL, arbutin demonstrated remarkable potential for radioprotection in vitro, observed both at the level of primary DNA damage, and using CBMN cytome assay.
Abstract: Arbutin is a simple phenolic glucoside biosynthesised in many plant families. Some of the everyday foods that contain arbutin are species of the genus Origanum, peaches, cereal products, coffee and tea and Arctostaphyllos uva ursi L. leaves. Arbutin possesses various beneficial effects in the organism, and was confirmed effective in the treatment of urinary tract infections as well as in preventing skin hyperpigmentation. It shows antioxidant and anti-inflammatory properties, and antitumor activity. The aim of this study was to explore potential radioprotective properties of arbutin in concentrations of 11.4 μg/mL, 57 μg/mL, 200 μg/mL and 400 μg/mL administered as a pre-treatment for one hour before exposing human leukocytes to ionising radiation at a therapeutic dose of 2 Gy. The alkaline comet assay was used to establish the levels of primary DNA damage, and cytokinesis-block micronucleus (CBMN) cytome assay to determine the level of cytogenetic damage. None of the tested concentrations of single arbutin showed genotoxic and cytotoxic effects. Even at the lowest tested concentration, 11.4 μg/mL, arbutin demonstrated remarkable potential for radioprotection in vitro, observed both at the level of primary DNA damage, and using CBMN cytome assay. The best dose reduction compared with amifostine was observed after pre-treatment with the highest concentration of arbutin, corresponding to 400 μg/mL. Promising results obtained on the leukocyte model speak in favour of extending similar experiments on other cell and animal models.
TL;DR: The work provides some insight into why the plant is included in remedies for cancers, cardiovascular complications and diabetes, and reveals it as a potential source of novel therapeutics.
Abstract: Abelmoschus esculentus (Okra) is used in the traditional treatment of cancer, hyperlipidaemia and hyperglycaemia. We, therefore, investigated its composition and potential cytotoxic or antioxidant properties that might underlie its phytotherapeutic applications. Its methanolic fruit extract yielded compounds 1, 2 and 3, identified through NMR, UV and MS analyses as olean‐12‐en‐3‐O‐β‐d‐glucopyranoside, isoquercitrin (quercetin glucoside) and 5,7,3′,4′‐tetrahydroxy‐flavonol‐3‐O‐[β‐d‐glucopyranosyl‐(1→6)]‐β‐d‐glucopyranoside (quercetin diglucoside), respectively. Following 48 h exposure, oleanene glucoside was mildly toxic to the HeLa and the MRC5‐SV2 cancer cells, isoquercitrin was not toxic except at 100 μg/ml in HeLa, and quercetin diglucoside elicited no toxicity. In a 2′,7′‐dichlorofluorescein diacetate (DCFDA) assay of intracellular levels of reactive oxygen species (ROS), hydrogen peroxide increased ROS levels, an effect not affected by oleanene glucoside but protected against by isoquercitrin and quercetin diglucoside, with IC50 values, respectively, of 2.7±0.5 μg/ml and 1.9±0.2 μg/ml (3 h post‐treatment) and 2.0±0.8 μg/ml and 1.5±0.4 μg/ml (24 h post‐treatment.) This is the first report of this oleanene skeleton triterpenoid in the plant. The work provides some insight into why the plant is included in remedies for cancers, cardiovascular complications and diabetes, and reveals it as a potential source of novel therapeutics.
TL;DR: In this paper, the structure of six gallotannins, three ellagitannins (7, 9), a neolignan glucoside (10), and three related polyphenolic compounds (gallic acid, 11 and 12) from Trapa bispinosa Roxb. pericarp extract (TBE) was determined through nuclear magnetic resonance and circular dichroism analyses.
Abstract: In this study, we present the isolation and characterization of the structure of six gallotannins (1–6), three ellagitannins (7–9), a neolignan glucoside (10), and three related polyphenolic compounds (gallic acid, 11 and 12) from Trapa bispinosa Roxb. pericarp extract (TBE). Among the isolates, the structure of compound 10 possessing a previously unclear absolute configuration was unambiguously determined through nuclear magnetic resonance and circular dichroism analyses. The α-glucosidase activity and glycation inhibitory effects of the isolates were evaluated. Decarboxylated rugosin A (8) showed an α-glucosidase inhibitory activity, while hydrolyzable tannins revealed stronger antiglycation activity than that of the positive control. Furthermore, the identification and quantification of the TBE polyphenols were investigated by high-performance liquid chromatography coupled to ultraviolet detection and electrospray ionization mass spectrometry analysis, indicating the predominance of gallic acid, ellagic acid, and galloyl glucoses showing marked antiglycation properties. These findings suggest that there is a potential food industry application of polyphenols in TBE as a functional food with antidiabetic and antiglycation activities.
TL;DR: In this paper, it was shown that in Arabidopsis thaliana malonylation of BR brassinolide is catalyzed by the acyltransferase phenolic glucoside malonyl-transferase 1 (PMAT1), which is also known to malonylate phenolic glucose and lipid amides and showed that an overexpression of PMAT1 in plants where UGT73C6 was also overexpressed, and thus, BL-23O-Glc formation was promoted, enhanced the symptoms of BR-deficiency of UGT
27 Jan 2021
TL;DR: In this paper, the authors demonstrate that Citrusin C is subjected to complete degradation by salivary/oral cavity microorganisms, showing that in the human oral cavity, virtually all β-Dglucosides would follow this type of hydrolysis.
Abstract: Eugenyl-β-D-glucopyranoside, also referred to as Citrusin C, is a natural glucoside found among others in cloves, basil and cinnamon plants. Eugenol in a form of free aglycone is used in perfumeries, flavourings, essential oils and in medicinal products. Synthetic Citrusin C was incubated with human saliva in several in vitro models together with substrate-specific enzyme and antibiotics (clindamycin, ciprofloxacin, amoxicillin trihydrate and potassium clavulanate). Citrusin C was detected using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Citrusin C was completely degraded only when incubated with substrate-specific A. niger glucosidase E.C 3.2.1.21 (control sample) and when incubated with human saliva (tested sample). The addition of antibiotics to the above-described experimental setting, stopped Citrusin C degradation, indicating microbiologic origin of hydrolysis observed. Our results demonstrate that Citrusin C is subjected to complete degradation by salivary/oral cavity microorganisms. Extrapolation of our results allows to state that in the human oral cavity, virtually all β-D-glucosides would follow this type of hydrolysis. Additionally, a new method was developed for an in vivo rapid test of glucosidase activity in the human mouth on the tongue using fluorescein-di-β-D-glucoside as substrate. The results presented in this study serve as a proof of concept for the hypothesis that microbial hydrolysis path of β-D-glucosides begins immediately in the human mouth and releases the aglycone directly into the gastrointestinal tract.
TL;DR: In this article, C. hirtus L'Her methanol extract was studied by NMR and two different LC-DAD-MSn using electrospray (ESI) and atmospheric pressure chemical ionization (APCI) sources to obtain a quali-quantitative fingerprint.
Abstract: Croton hirtus L'Her methanol extract was studied by NMR and two different LC-DAD-MSn using electrospray (ESI) and atmospheric pressure chemical ionization (APCI) sources to obtain a quali-quantitative fingerprint. Forty different phytochemicals were identified, and twenty of them were quantified, whereas the main constituents were dihydro α ionol-O-[arabinosil(1-6) glucoside] (133 mg/g), dihydro β ionol-O-[arabinosil(1-6) glucoside] (80 mg/g), β-sitosterol (49 mg/g), and isorhamnetin-3-O-rutinoside (26 mg/g). C. hirtus was extracted with different solvents-namely, water, methanol, dichloromethane, and ethyl acetate-and the extracts were assayed using different in vitro tests. The methanolic extracts presented the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRAP) values. All the tested extracts exhibited inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with a higher activity observed for dichloromethane (AChE: 5.03 and BChE: 16.41 mgGALAE/g), while the methanolic extract showed highest impact against tyrosinase (49.83 mgKAE/g). Taken together, these findings suggest C. hirtus as a novel source of bioactive phytochemicals with potential for commercial development.
TL;DR: In this paper, the main chemical constituents present in Citharexylum myrianthum and its diuretic effect in rats were identified and analyzed using spectroscopic analysis, including 1D and 2D NMR, LC-ESI-MS/MS, and EIMS data.
TL;DR: In this article, chemical fractionation of the n-BuOH partition, which was generated from the EtOH extract of the flower buds of Tussilago farfara, afforded a series of polar constituents including four new sesquiterpenoids ( 1 − 4 ), one new sediterpenoid glucoside ( 5 ) and one known analogue ( 6 ) of the eudesmane type, as well as five known quinic acid derivatives ( 7 − 11 ).
TL;DR: The allylated acteOSide derivative and 2,6-dimethoxybenzophenone showed weak cytotoxicity while acteoside showed a good antioxidant activity, and the chemotaxonomic significance of the isolated compound is discussed.
TL;DR: In this paper, a biocatalytic strategy for the efficient synthesis of a possibly valuable hydroxylated product, 3-OH phlorizin, was developed via CYP102A1-catalyzed regioselective hyroxylation.
Abstract: Phlorizin is the most abundant glucoside of phloretin from the apple tree and its products. Phlorizin and its aglycone phloretin are currently considered health-beneficial polyphenols from apples useful in treating hyperglycemia and obesity. Recently, we showed that phloretin could be regioselectively hydroxylated to make 3-OH phloretin by Bacillus megaterium CYP102A1 and human P450 enzymes. The 3-OH phloretin has a potent inhibitory effect on differentiating 3T3-L1 preadipocytes into adipocytes and lipid accumulation. The glucoside of 3-OH phloretin would be a promising agent with increased bioavailability and water solubility compared with its aglycone. However, procedures to make 3-OH phlorizin, a glucoside of 3-OH phloretin, using chemical methods, are not currently available. Here, a biocatalytic strategy for the efficient synthesis of a possibly valuable hydroxylated product, 3-OH phlorizin, was developed via CYP102A1-catalyzed regioselective hydroxylation. The production of 3-OH phlorizin by CYP102A1 was confirmed by HPLC and LC-MS spectroscopy in addition to enzymatic removal of its glucose moiety for comparison to 3-OH phloretin. Taken together, in this study, we found a panel of mutants from B. megaterium CYP102A1 could catalyze regioselective hydroxylation of phlorizin to produce 3-OH phlorizin, a catechol product.
TL;DR: In this paper, Gay et al. investigated the antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of Cota altissima L. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoy lquinic acids, isorhamnetin glucoside, quercetin and quercetein glucoseside by LC-MS/MS.
Abstract: Phytochemical profiles of essential oil (EO), fatty acids, and n-hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of Cota altissima L. J. Gay (syn. Anthemis altissima L.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and β-caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and α-glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens. CAM showed the highest antioxidant activity against DPPH and ABTS radicals with IC50 values of 126.60 and 144.40 μg/mL, respectively. In the anti-inflammatory activity, CAE demonstrated the highest antilipoxygenase activity with an IC50 value of 105.40 μg/mL, whereas, CAD showed the best inhibition of α-glucosidase with an IC50 value of 396.40 μg/mL in the antidiabetic activity. CAH was effective against Staphylococcus aureus at MIC = 312.5 µg/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of C. altissima.